4Y32

Crystal structure of C-terminal modified Tau peptide-hybrid 109B with 14-3-3sigma

Summary for 4Y32

Entry DOI	10.2210/pdb4y32/pdb
Related	4FL5 4Y3B 4Y3V 4Y5I
Descriptor	14-3-3 protein sigma, ARG-THR-PRO-SEP-LEU-PRO-CNC(C(C)O)C(=O)N1CCCC1CCOC, (2S)-2-(2-methoxyethyl)pyrrolidine, ... (4 entities in total)
Functional Keywords	peptide-hybrid, inhibitor, protein-protein interaction, peptide binding protein, adapter protein, 14-3-3, signaling protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	54918.75
Authors	Bartel, M.,Milroy, L.,Bier, D.,Brunsveld, L.,Ottmann, C. (deposition date: 2015-02-10, release date: 2015-12-23, Last modification date: 2024-01-10)
Primary citation	Milroy, L.G.,Bartel, M.,Henen, M.A.,Leysen, S.,Adriaans, J.M.,Brunsveld, L.,Landrieu, I.,Ottmann, C. Stabilizer-Guided Inhibition of Protein-Protein Interactions. Angew.Chem.Int.Ed.Engl., 54:15720-15724, 2015 Cited by PubMed: 26537010 DOI: 10.1002/anie.201507976 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation