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6PAH
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BU of 6pah by Molmil
HUMAN PHENYLALANINE HYDROXYLASE CATALYTIC DOMAIN DIMER WITH BOUND L-DOPA (3,4-DIHYDROXYPHENYLALANINE) INHIBITOR
Descriptor: 3,4-DIHYDROXYPHENYLALANINE, FE (III) ION, PHENYLALANINE 4-MONOOXYGENASE
Authors:Erlandsen, H, Flatmark, T, Stevens, R.C.
Deposit date:1998-08-20
Release date:1999-04-27
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystallographic analysis of the human phenylalanine hydroxylase catalytic domain with bound catechol inhibitors at 2.0 A resolution.
Biochemistry, 37, 1998
4V06
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BU of 4v06 by Molmil
Crystal structure of human tryptophan hydroxylase 2 (TPH2), catalytic domain
Descriptor: FE (III) ION, IMIDAZOLE, TRYPTOPHAN 5-HYDROXYLASE 2
Authors:Kopec, J, Oberholzer, A, Fitzpatrick, F, Newman, J, Tallant, C, Kiyani, W, Shrestha, L, Burgess-Brown, N, von Delft, F, Arrowsmith, C, Edwards, A, Bountra, C, Yue, W.W.
Deposit date:2014-09-11
Release date:2014-10-15
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:Crystal Structure of Human Tryptophane Hydroxylase 2 (Tph2), Catalytic Domain
To be Published
3E2T
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BU of 3e2t by Molmil
The catalytic domain of chicken tryptophan hydroxylase 1 with bound tryptophan
Descriptor: FE (III) ION, IMIDAZOLE, SULFATE ION, ...
Authors:Windahl, M.S, Petersen, C.R, Christensen, H.E.C, Harris, P.
Deposit date:2008-08-06
Release date:2008-11-04
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of tryptophan hydroxylase with bound amino acid substrate
Biochemistry, 47, 2008
5TPG
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BU of 5tpg by Molmil
Optimization of spirocyclic proline tryptophanhydroxylase-1 inhibitors
Descriptor: (3S)-8-(2-amino-6-{(1R)-1-[5-chloro-3'-(methylsulfonyl)[1,1'-biphenyl]-2-yl]-2,2,2-trifluoroethoxy}pyrimidin-4-yl)-2,8-diazaspiro[4.5]decane-3-carboxylic acid, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETONITRILE, ...
Authors:Stein, A.J, Goldberg, D.R, De Lombaert, S, Holt, M.C.
Deposit date:2016-10-20
Release date:2017-01-25
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Optimization of spirocyclic proline tryptophan hydroxylase-1 inhibitors.
Bioorg. Med. Chem. Lett., 27, 2017
2XSN
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BU of 2xsn by Molmil
Crystal Structure of Human Tyrosine Hydroxylase Catalytic Domain
Descriptor: TYROSINE 3-MONOOXYGENASE, ZINC ION
Authors:Muniz, J.R.C, Cooper, C.D.O, Yue, W.W, Krysztofinska, E, von Delft, F, Knapp, S, Gileadi, O, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Kavanagh, K.L, Oppermann, U.
Deposit date:2010-10-29
Release date:2010-11-17
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Crystal Structure of Human Tyrosine Hydroxylase Catalytic Domain
To be Published
4PAH
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BU of 4pah by Molmil
HUMAN PHENYLALANINE HYDROXYLASE CATALYTIC DOMAIN DIMER WITH BOUND NOR-ADRENALINE INHIBITOR
Descriptor: FE (III) ION, L-NOREPINEPHRINE, PHENYLALANINE HYDROXYLASE
Authors:Erlandsen, H, Flatmark, T, Stevens, R.C.
Deposit date:1998-08-20
Release date:1999-04-27
Last modified:2013-02-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystallographic analysis of the human phenylalanine hydroxylase catalytic domain with bound catechol inhibitors at 2.0 A resolution.
Biochemistry, 37, 1998
5PAH
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BU of 5pah by Molmil
HUMAN PHENYLALANINE HYDROXYLASE CATALYTIC DOMAIN DIMER WITH BOUND DOPAMINE INHIBITOR
Descriptor: FE (III) ION, L-DOPAMINE, PHENYLALANINE 4-MONOOXYGENASE
Authors:Erlandsen, H, Flatmark, T, Stevens, R.C.
Deposit date:1998-08-20
Release date:1999-04-27
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystallographic analysis of the human phenylalanine hydroxylase catalytic domain with bound catechol inhibitors at 2.0 A resolution.
Biochemistry, 37, 1998
3PAH
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BU of 3pah by Molmil
HUMAN PHENYLALANINE HYDROXYLASE CATALYTIC DOMAIN DIMER WITH BOUND ADRENALINE INHIBITOR
Descriptor: 4-[(1S)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol, FE (III) ION, PHENYLALANINE HYDROXYLASE
Authors:Erlandsen, H, Flatmark, T, Stevens, R.C.
Deposit date:1998-08-20
Release date:1999-04-27
Last modified:2013-03-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystallographic analysis of the human phenylalanine hydroxylase catalytic domain with bound catechol inhibitors at 2.0 A resolution.
Biochemistry, 37, 1998
5J6D
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BU of 5j6d by Molmil
Discovery of acyl guanidine tryptophan hydroxylase-1 inhibitors
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 4-[(N-{[2-(3-methoxyphenoxy)-6-(piperidin-1-yl)phenyl]methyl}carbamimidoyl)carbamoyl]-L-phenylalanine, FE (III) ION, ...
Authors:Stein, A.J, Goldberg, D.R, De Lombaert, S.
Deposit date:2016-04-04
Release date:2016-05-25
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discovery of acyl guanidine tryptophan hydroxylase-1 inhibitors.
Bioorg.Med.Chem.Lett., 26, 2016
1DMW
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BU of 1dmw by Molmil
CRYSTAL STRUCTURE OF DOUBLE TRUNCATED HUMAN PHENYLALANINE HYDROXYLASE WITH BOUND 7,8-DIHYDRO-L-BIOPTERIN
Descriptor: 7,8-DIHYDROBIOPTERIN, FE (III) ION, PHENYLALANINE HYDROXYLASE
Authors:Erlandsen, H, Stevens, R.C, Flatmark, T.
Deposit date:1999-12-15
Release date:2000-03-24
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure and site-specific mutagenesis of pterin-bound human phenylalanine hydroxylase.
Biochemistry, 39, 2000
4ETL
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BU of 4etl by Molmil
Crystallographic structure of phenylalanine hydroxylase from Chromobacterium violaceum F258A mutation
Descriptor: COBALT (II) ION, Phenylalanine-4-hydroxylase
Authors:Ronau, J.A, Paul, L.P, Corn, I.R, Wagner, K.T, Abu-Omar, M.M, Das, C.
Deposit date:2012-04-24
Release date:2013-05-08
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:An additional substrate binding site in a bacterial phenylalanine hydroxylase.
Eur.Biophys.J., 42, 2013
4JPY
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BU of 4jpy by Molmil
Iron and phenylalanine bound crystal structure of phenylalanine hydroxylase from Chromobacterium violaceum
Descriptor: FE (III) ION, PHENYLALANINE, Phenylalanine-4-hydroxylase
Authors:Ronau, J.A, Abu-Omar, M.M, Das, C.
Deposit date:2013-03-19
Release date:2013-08-07
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:An additional substrate binding site in a bacterial phenylalanine hydroxylase.
Eur.Biophys.J., 42, 2013
7VGM
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BU of 7vgm by Molmil
Crystal structure of Phenylalanine hydroxylase from Bacillus cereus ATCC 14579
Descriptor: 1,2-ETHANEDIOL, ACETIC ACID, DI(HYDROXYETHYL)ETHER, ...
Authors:Park, J, Kim, K.-J.
Deposit date:2021-09-17
Release date:2022-04-27
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Structural studies of a novel auxiliary-domain-containing phenylalanine hydroxylase from Bacillus cereus ATCC 14579.
Acta Crystallogr D Struct Biol, 78, 2022
4JPX
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BU of 4jpx by Molmil
Crystal structure of phenylalanine hydroxylase S203P mutant from Chromobacterium violaceum
Descriptor: COBALT (II) ION, PHENYLALANINE, Phenylalanine-4-hydroxylase
Authors:Ronau, J.A, Abu-Omar, M.M, Das, C.
Deposit date:2013-03-19
Release date:2013-08-07
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:An additional substrate binding site in a bacterial phenylalanine hydroxylase.
Eur.Biophys.J., 42, 2013
4ANP
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BU of 4anp by Molmil
Crystal structure of human phenylalanine hydroxylase in complex with a pharmacological chaperone
Descriptor: 5,6-DIMETHYL-3-(4-METHYL-2-PYRIDINYL)-2-THIOXO-2,3-DIHYDROTHIENO[2,3- D]PYRIMIDIN-4(1H)-ONE, FE (III) ION, PHENYLALANINE-4-HYDROXYLASE
Authors:Torreblanca, R, Lira-Navarrete, E, Sancho, J, Hurtado-Guerrero, R.
Deposit date:2012-03-21
Release date:2012-04-11
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Structural and Mechanistic Basis of the Interaction between a Pharmacological Chaperone and Human Phenylalanine Hydroxylase.
Chembiochem, 13, 2012
2PAH
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BU of 2pah by Molmil
TETRAMERIC HUMAN PHENYLALANINE HYDROXYLASE
Descriptor: FE (III) ION, PROTEIN (PHENYLALANINE HYDROXYLASE)
Authors:Stevens, R.C, Fusetti, F, Erlandsen, H.
Deposit date:1998-05-26
Release date:1999-10-06
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of tetrameric human phenylalanine hydroxylase and its implications for phenylketonuria.
J.Biol.Chem., 273, 1998
7WIY
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BU of 7wiy by Molmil
Cryo-EM structure of human TPH2 tetramer
Descriptor: FE (III) ION, IMIDAZOLE, Tryptophan 5-hydroxylase 2
Authors:Zhu, K.F, Liu, C, Zhang, H.W, Wang, D.P.
Deposit date:2022-01-05
Release date:2022-10-05
Last modified:2024-06-26
Method:ELECTRON MICROSCOPY (3.09 Å)
Cite:Cryo-EM Structure and Activator Screening of Human Tryptophan Hydroxylase 2.
Front Pharmacol, 13, 2022
4BPT
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BU of 4bpt by Molmil
Structural and thermodynamic insight into phenylalanine hydroxylase from the human pathogen Legionella pneumophila
Descriptor: DI(HYDROXYETHYL)ETHER, PHENYLALANINE-4-HYDROXYLASE (PAH) (PHE-4-MONOOXYGENASE)
Authors:Leiros, H.-K.S, Flydal, M.I, Martinez, A.
Deposit date:2013-05-28
Release date:2013-08-21
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural and Thermodynamic Insight Into Phenylalanine Hydroxylase from the Human Pathogen Legionella Pneumophila.
FEBS Open Bio, 3, 2013
4ESM
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BU of 4esm by Molmil
Crystallographic structure of phenylalanine hydroxylase from Chromobacterium violaceum Y155A mutation
Descriptor: COBALT (II) ION, Phenylalanine-4-hydroxylase
Authors:Ronau, J.A, Paul, L.P, Corn, I.R, Wagner, K.T, Abu-Omar, M.M, Das, C.
Deposit date:2012-04-23
Release date:2013-05-08
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:An additional substrate binding site in a bacterial phenylalanine hydroxylase.
Eur.Biophys.J., 42, 2013
3TK4
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BU of 3tk4 by Molmil
Crystal structure of phenylalanine hydroxylase from Chromobacterium violaceum bound to cobalt
Descriptor: COBALT (II) ION, Phenylalanine-4-hydroxylase
Authors:Ronau, J.A, Abu-Omar, M.M, Das, C.
Deposit date:2011-08-25
Release date:2012-09-05
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:An additional substrate binding site in a bacterial phenylalanine hydroxylase.
Eur.Biophys.J., 42, 2013
1TOH
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BU of 1toh by Molmil
TYROSINE HYDROXYLASE CATALYTIC AND TETRAMERIZATION DOMAINS FROM RAT
Descriptor: FE (III) ION, TYROSINE HYDROXYLASE
Authors:Goodwill, K.E, Sabatier, C, Stevens, R.C.
Deposit date:1997-06-04
Release date:1998-06-03
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of tyrosine hydroxylase at 2.3 A and its implications for inherited neurodegenerative diseases.
Nat.Struct.Biol., 4, 1997
3HFB
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BU of 3hfb by Molmil
Crystal structure of human tryoptophan hydroxylase type 1 with LP-534193
Descriptor: 4-(5-{[(2'-methylbiphenyl-2-yl)methyl]amino}pyrazin-2-yl)-L-phenylalanine, FE (III) ION, Tryptophan 5-hydroxylase 1
Authors:Tari, L.W, Swanson, R.V, Hunter, M.J.
Deposit date:2009-05-11
Release date:2010-04-21
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Mechanism of Inhibition of Novel Tryptophan Hydroxylase Inhibitors Revealed by Co-crystal Structures and Kinetic Analysis.
Curr Chem Genomics, 4, 2010
3HF6
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BU of 3hf6 by Molmil
Crystal structure of human tryptophan hydroxylase type 1 with bound LP-521834 and FE
Descriptor: 4-(4-amino-6-{[(1R)-1-naphthalen-2-ylethyl]amino}-1,3,5-triazin-2-yl)-L-phenylalanine, FE (III) ION, Tryptophan 5-hydroxylase 1
Authors:Tari, L.W, Swanson, R.V, Hunter, M.J.
Deposit date:2009-05-11
Release date:2009-11-24
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Mechanism of Inhibition of Novel Tryptophan Hydroxylase Inhibitors Revealed by Co-crystal Structures and Kinetic Analysis
Curr Chem Genomics, 4, 2010
3HF8
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BU of 3hf8 by Molmil
Crystal structure of human tryoptophan hydroxylase type 1 with bound LP-533401 and Fe
Descriptor: 4-{2-amino-6-[(1R)-2,2,2-trifluoro-1-(3'-fluorobiphenyl-4-yl)ethoxy]pyrimidin-4-yl}-L-phenylalanine, FE (III) ION, Tryptophan 5-hydroxylase 1
Authors:Tari, L.W, Swanson, R.V, Hunter, M.J.
Deposit date:2009-05-11
Release date:2010-04-21
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Mechanism of Inhibition of Novel Tryptophan Hydroxylase Inhibitors Revealed by Co-crystal Structures and Kinetic Analysis.
Curr Chem Genomics, 4, 2010
1TDW
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BU of 1tdw by Molmil
Crystal structure of double truncated human phenylalanine hydroxylase BH4-responsive PKU mutant A313T.
Descriptor: FE (III) ION, Phenylalanine-4-hydroxylase
Authors:Erlandsen, H, Pey, A.L, Gamez, A, Perez, B, Desviat, L.R, Aguado, C, Koch, R, Surendran, S, Tyring, S, Matalon, R, Scriver, C.R, Ugarte, M, Martinez, A, Stevens, R.C.
Deposit date:2004-05-24
Release date:2004-11-30
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Correction of kinetic and stability defects by tetrahydrobiopterin in phenylketonuria patients with certain phenylalanine hydroxylase mutations.
Proc.Natl.Acad.Sci.Usa, 101, 2004

 

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