4ANP

Crystal structure of human phenylalanine hydroxylase in complex with a pharmacological chaperone

Summary for 4ANP

Entry DOI	10.2210/pdb4anp/pdb
Related	1DMW 1J8T 1J8U 1KW0 1LRM 1MMK 1MMT 1PAH 1TDW 1TG2 2PAH 3PAH 4PAH 5PAH 6PAH
Descriptor	PHENYLALANINE-4-HYDROXYLASE, FE (III) ION, 5,6-DIMETHYL-3-(4-METHYL-2-PYRIDINYL)-2-THIOXO-2,3-DIHYDROTHIENO[2,3- D]PYRIMIDIN-4(1H)-ONE, ... (4 entities in total)
Functional Keywords	oxidoreductase, phenylketonuria, folding mechanism
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	37903.77
Authors	Torreblanca, R.,Lira-Navarrete, E.,Sancho, J.,Hurtado-Guerrero, R. (deposition date: 2012-03-21, release date: 2012-04-11, Last modification date: 2023-12-20)
Primary citation	Torreblanca, R.,Lira-Navarrete, E.,Sancho, J.,Hurtado-Guerrero, R. Structural and Mechanistic Basis of the Interaction between a Pharmacological Chaperone and Human Phenylalanine Hydroxylase. Chembiochem, 13:1266-, 2012 Cited by PubMed: 22549968 DOI: 10.1002/CBIC.201200188 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.11 Å)

Structure validation