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3JWA
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BU of 3jwa by Molmil
Crystal structure of L-methionine gamma-lyase from Citrobacter freundii with methionine phosphinate
Descriptor: (1-AMINO-3-METHYLSULFANYL-PROPYL)-PHOSPHINIC ACID, DI(HYDROXYETHYL)ETHER, Methionine gamma-lyase
Authors:Revtovish, S.V, Nikulin, A.D, Morozova, E.A, Demidkina, T.V.
Deposit date:2009-09-18
Release date:2010-09-08
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Three-dimensional structures of noncovalent complexes of Citrobacter freundii methionine gamma-lyase with substrates.
Biochemistry Mosc., 76, 2011
5M3Z
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BU of 5m3z by Molmil
Crystal structure of Citrobacter freundii methionine gamma-lyase with C115H replacement in the complex with L-norleucine
Descriptor: 2-[O-PHOSPHONOPYRIDOXYL]-AMINO-HEXANOIC ACID, Methionine gamma-lyase, NORLEUCINE, ...
Authors:Revtovich, S.V, Nikulin, A.D, Anufrieva, N.V, Morozova, E.A, Demidkina, T.V.
Deposit date:2016-10-17
Release date:2017-06-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Crystal structure of mutant form Cys115His of Citrobacter freundii methionine gamma-lyase complexed with l-norleucine.
Biochim. Biophys. Acta, 1865, 2017
5K30
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BU of 5k30 by Molmil
Crystal structure of methionine gamma-lyase from Citrobacter freundii modified by S-Ethyl-L-cysteine sulfoxide
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DI(HYDROXYETHYL)ETHER, Methionine gamma-lyase, ...
Authors:Revtovich, S.V, Nikulin, A.D, Morozova, E.A, Demidkina, T.V.
Deposit date:2016-05-19
Release date:2017-07-12
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Sulfoxides of sulfur-containing amino acids are suicide substrates of Citrobacter freundii methionine gamma-lyase. Structural bases of the enzyme inactivation.
Biochimie, 168, 2020
7SWH
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BU of 7swh by Molmil
Crystal Structure of Putative cystathionine gamma-synthase from Burkholderia pseudomallei in Complex with PLP
Descriptor: 1,2-ETHANEDIOL, Putative cystathionine gamma-synthase
Authors:Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2021-11-19
Release date:2021-12-01
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystal Structure of Putative cystathionine gamma-synthase from Burkholderia pseudomallei in Complex with PLP
to be published
2RFV
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BU of 2rfv by Molmil
High resolution structure of L-methionine gamma-lyase from Citrobacter freundii
Descriptor: CHLORIDE ION, Methionine gamma-lyase
Authors:Nikulin, A.D, Revtovich, S.V, Morozova, E.A, Nevskaya, N.A, Nikonov, S.V, Garber, M.B, Demidkina, T.V.
Deposit date:2007-10-02
Release date:2008-08-19
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.355 Å)
Cite:High-resolution structure of methionine gamma-lyase from Citrobacter freundii.
Acta Crystallogr.,Sect.D, 64, 2008
4XQ2
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BU of 4xq2 by Molmil
Ensemble refinement of cystathione gamma lyase (CalE6) D7G from Micromonospora echinospora
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, CalE6, ...
Authors:Wang, F, Yennamalli, R.M, Singh, S, Tan, K, Thorson, J.S, Phillips Jr, G.N, Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2015-01-18
Release date:2015-04-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The crystal structure of cystathione gamma lyase (CalE6) from Micromonospora echinospora
To Be Published
5IJG
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BU of 5ijg by Molmil
Crystal structure of O-acetylhomoserine sulfhydrolase from Brucella melitensis at 2.0 A resolution
Descriptor: Cys/Met metabolism pyridoxal-phosphate-dependent enzyme, GLYCEROL, PYRIDOXAL-5'-PHOSPHATE
Authors:Boyko, K.M, Nikolaeva, A.Y, Koolikova, V.V, Kotlov, M.I, Demidkina, T.V, Popov, V.O.
Deposit date:2016-03-02
Release date:2017-04-05
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of O-acetylhomoserine sulfhydrolase from Brucella melitensis at 2.0 A resolution
To Be Published
3MKJ
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BU of 3mkj by Molmil
Methionine gamma-lyase from Citrobacter freundii with pyridoximine-5'-phosphate
Descriptor: Methionine gamma-lyase, [5-hydroxy-4-(iminomethyl)-6-methyl-pyridin-3-yl]methyl dihydrogen phosphate
Authors:Revtovich, S.V, Nikulin, A.D, Morozova, E.A, Demidkina, T.V.
Deposit date:2010-04-15
Release date:2010-08-11
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Exploring methionine gamma-lyase structure-function relationship via microspectrophotometry and X-ray crystallography
Biochim.Biophys.Acta, 1814, 2011
8DUY
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BU of 8duy by Molmil
Crystal structure of Cystathionine beta-lyase from Klebsiella pneumoniae
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, Cystathionine beta-lyase
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2022-07-27
Release date:2022-08-10
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structure of Cystathionine beta-lyase from Klebsiella pneumoniae
To be Published
6S0C
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BU of 6s0c by Molmil
Crystal structure of methionine gamma-lyase from Citrobacter freundii modified by dimethylthiosulfinate
Descriptor: Cystathionine gamma-synthase, PYRIDOXAL-5'-PHOSPHATE, TRIETHYLENE GLYCOL
Authors:Revtovich, S.V, Morozova, E.A, Nikulin, A.D, Demidkina, T.V.
Deposit date:2019-06-14
Release date:2020-04-22
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:Sulfoxides of sulfur-containing amino acids are suicide substrates of Citrobacter freundii methionine gamma-lyase. Structural bases of the enzyme inactivation.
Biochimie, 168, 2020
7YEO
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BU of 7yeo by Molmil
Crystal Structure of cystathionine gamma-synthase-like protein C23A1.14c
Descriptor: MAGNESIUM ION, PYRIDOXAL-5'-PHOSPHATE, Uncharacterized trans-sulfuration enzyme C23A1.14c
Authors:Zhang, S.J.
Deposit date:2022-07-06
Release date:2023-01-11
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal Structure of cystathionine gamma-synthase-like protein C23A1.14c
To Be Published
1UKJ
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BU of 1ukj by Molmil
Detailed structure of L-Methionine-Lyase from Pseudomonas putida
Descriptor: Methionine gamma-lyase, SULFATE ION
Authors:Misaki, S, Takimoto, A, Takakura, T, Yoshioka, T, Yamashita, M, Tamura, T, Tanaka, H, Inagaki, K.
Deposit date:2003-08-24
Release date:2004-10-19
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Detailed structure of L-Methionine -Lyase from Pseudomonas putida
To be Published
8J6N
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BU of 8j6n by Molmil
Crystal structure of Cystathionine gamma-lyase in complex with compound 1
Descriptor: 1,2-ETHANEDIOL, Cystathionine gamma-lyase, GLYCEROL, ...
Authors:Hibi, R, Toma-Fukai, S, Shimizu, T, Hanaoka, K.
Deposit date:2023-04-26
Release date:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discovery of a cystathionine gamma-lyase (CSE) selective inhibitor targeting active-site pyridoxal 5'-phosphate (PLP) via Schiff base formation.
Sci Rep, 13, 2023
1Y4I
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BU of 1y4i by Molmil
Crystal structure of Citrobacter Freundii L-methionine-lyase
Descriptor: SULFATE ION, methionine gamma-lyase
Authors:Revtovich, S.V, Mamaeva, D.V, Morozova, E.A, Nikulin, A.D, Nikonov, S.V, Garber, M.B, Demidkina, T.V.
Deposit date:2004-12-01
Release date:2005-06-14
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of Citrobacter freundii L-methionine gamma-lyase.
Acta Crystallogr.,Sect.F, 61, 2005
5X5H
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BU of 5x5h by Molmil
Crystal structure of metB from Corynebacterium glutamicum
Descriptor: Cystathionine beta-lyases/cystathionine gamma-synthases, GLYCEROL, MAGNESIUM ION, ...
Authors:Sagong, H.-Y, Kim, K.-J.
Deposit date:2017-02-16
Release date:2017-03-01
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.51 Å)
Cite:Structural Insights into Substrate Specificity of Cystathionine gamma-Synthase from Corynebacterium glutamicum
J. Agric. Food Chem., 65, 2017
5X2X
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BU of 5x2x by Molmil
Crystal structure of Pseudomonas putida methionine gamma-lyase wild type with L-homocysteine intermediates
Descriptor: (2E)-2-{[(1E)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene]amino}but-2-enoic acid, HYDROSULFURIC ACID, L-methionine gamma-lyase
Authors:Shiba, T, Sato, D, Harada, S.
Deposit date:2017-02-02
Release date:2017-04-12
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and mechanistic insights into homocysteine degradation by a mutant of methionine gamma-lyase based on substrate-assisted catalysis
Protein Sci., 26, 2017
5TT2
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BU of 5tt2 by Molmil
Inactive conformation of engineered human cystathionine gamma lyase (E59N, R119L, E339V) to depleting methionine
Descriptor: Cystathionine gamma-lyase, SULFATE ION
Authors:Yan, W, Zhang, Y.
Deposit date:2016-10-31
Release date:2017-10-11
Last modified:2019-11-27
Method:X-RAY DIFFRACTION (2.949 Å)
Cite:Structural Snapshots of an Engineered Cystathionine-gamma-lyase Reveal the Critical Role of Electrostatic Interactions in the Active Site.
Biochemistry, 56, 2017
6NBA
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BU of 6nba by Molmil
Crystal structure of Human Cystathionine gamma lyase with S-3-Carboxpropyl-L-Cysteine
Descriptor: 2-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]ACRYLIC ACID, Cystathionine gamma-lyase
Authors:Kim, H, Yadav, P.K, Banerjee, R, Cho, U.-S.
Deposit date:2018-12-06
Release date:2019-06-12
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.495 Å)
Cite:S-3-Carboxypropyl-l-cysteine specifically inhibits cystathionine gamma-lyase-dependent hydrogen sulfide synthesis.
J.Biol.Chem., 294, 2019
8JUI
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BU of 8jui by Molmil
Crystal structures of Cystathionine beta lyase from Bacillus cereus ATCC 14579
Descriptor: Cystathionine beta-lyase, PYRIDOXAL-5'-PHOSPHATE
Authors:Yu, H, Kim, K.-J.
Deposit date:2023-06-26
Release date:2024-07-03
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of Cystathionine beta lyase from Bacillus cereus ATCC 14579
To Be Published
2FQ6
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BU of 2fq6 by Molmil
Cystathionine beta-lyase (cbl) from escherichia coli in complex with n-hydrazinocarbonylmethyl-2-trifluoromethyl-benzamide
Descriptor: Cystathionine beta-lyase, PHOSPHORIC ACID MONO-(5-HYDROXY-6-METHYL-4-{[2-(2-TRIFLUOROMETHYL-BENZOYLAMINO)-ACETYL]-HYDRAZONOMETHYL}-PYRIDIN-3-YLMETHYL)ESTER
Authors:Junop, M.S.
Deposit date:2006-01-17
Release date:2006-12-26
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Inhibitors of bacterial cystathionine beta-lyase: leads for new antimicrobial agents and probes of enzyme structure and function.
J.Med.Chem., 50, 2007
2CB1
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BU of 2cb1 by Molmil
Crystal Structure of O-actetyl Homoserine Sulfhydrylase From Thermus Thermophilus HB8,OAH2.
Descriptor: O-ACETYL HOMOSERINE SULFHYDRYLASE, PYRIDOXAL-5'-PHOSPHATE
Authors:Imagawa, T, Utsunomiya, H, Tsuge, H, Ebihara, A, Kanagawa, M, Nakagawa, N, Kuroishi, C, Agari, Y, Kuramitsu, S, Yokoyama, S.
Deposit date:2005-12-28
Release date:2007-01-03
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The Crystal Structure of O-Acetyl Homoserine Sulfhydrylase
To be Published
8OVH
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BU of 8ovh by Molmil
Crystal structure of O-acetyl-L-homoserine sulfhydrolase from Saccharomyces cerevisiae in complex with Pyridoxal-5'-phosphate
Descriptor: DI(HYDROXYETHYL)ETHER, Homocysteine/cysteine synthase, PYRIDOXAL-5'-PHOSPHATE
Authors:Saleem-Batcha, R, Andexer, J.N, Mohr, M.
Deposit date:2023-04-26
Release date:2023-06-21
Last modified:2024-09-18
Method:X-RAY DIFFRACTION (2.171 Å)
Cite:Structure, function and substrate preferences of archaeal S-adenosyl-L-homocysteine hydrolases.
Commun Biol, 7, 2024
6OVG
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BU of 6ovg by Molmil
L-Methionine Depletion with an Engineered Human Enzyme Disrupts Prostate Cancer Metabolism
Descriptor: Cystathionine gamma-lyase, SULFATE ION
Authors:Yan, W, Irani, S, Zhang, J.
Deposit date:2019-05-07
Release date:2020-04-22
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.719 Å)
Cite:Enzyme-mediated depletion of serum l-Met abrogates prostate cancer growth via multiple mechanisms without evidence of systemic toxicity.
Proc.Natl.Acad.Sci.USA, 117, 2020
2O7C
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BU of 2o7c by Molmil
Crystal structure of L-methionine-lyase from Pseudomonas
Descriptor: Methionine gamma-lyase, SULFATE ION
Authors:Misaki, S, Takimoto, A, Takakura, T, Yoshioka, T, Yamashita, M, Tamura, T, Tanaka, H, Inagaki, K.
Deposit date:2006-12-10
Release date:2007-12-11
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of the antitumour enzyme L-methionine gamma-lyase from Pseudomonas putida at 1.8 A resolution
J.Biochem.(Tokyo), 141, 2007
5TSU
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BU of 5tsu by Molmil
Active conformation for Engineered human cystathionine gamma lyase (E59N, R119L, E339V) to depleting methionine
Descriptor: CYSTEINE, Cystathionine gamma-lyase, METHIONINE, ...
Authors:Yan, W, Zhang, Y.
Deposit date:2016-10-31
Release date:2017-10-11
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Snapshots of an Engineered Cystathionine-gamma-lyase Reveal the Critical Role of Electrostatic Interactions in the Active Site.
Biochemistry, 56, 2017

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