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2KDW
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BU of 2kdw by Molmil
Solution structure of RppH mutant E53A from Escherichia coli
Descriptor: RNA pyrophosphohydrolase
Authors:Li, H, Bi, Y, Jin, C.
Deposit date:2009-01-19
Release date:2010-01-26
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Solution structure of RppH mutant E53A from Escherichia coli
To be Published
7ESF
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BU of 7esf by Molmil
The Crystal Structure of human MTH1 from Biortus
Descriptor: 7,8-dihydro-8-oxoguanine triphosphatase, DI(HYDROXYETHYL)ETHER, TETRAETHYLENE GLYCOL
Authors:Wang, F, Cheng, W, Shang, H, Wang, R, Zhang, B, Tian, F.
Deposit date:2021-05-10
Release date:2021-05-26
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:The Crystal Structure of human MTH1 from Biortus
To Be Published
7NR6
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BU of 7nr6 by Molmil
Structure of NUDT15 in complex with NSC56456
Descriptor: 1,2-ETHANEDIOL, 2-azanyl-9-cyclohexyl-3~{H}-purine-6-thione, MAGNESIUM ION, ...
Authors:Rehling, D, Stenmark, P.
Deposit date:2021-03-03
Release date:2022-03-23
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Coupling cellular target engagement to drug-induced responses with CeTEAM
To Be Published
1QVJ
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BU of 1qvj by Molmil
structure of NUDT9 complexed with ribose-5-phosphate
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5-O-phosphono-beta-D-ribofuranose, ADP-ribose pyrophosphatase, ...
Authors:Shen, B.W, Perraud, A.-L, Scharenberg, A.S, Stoddard, B.L.
Deposit date:2003-08-27
Release date:2003-09-16
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:The crystal structure and mutational analysis of human NUDT9
J.Mol.Biol., 332, 2003
6QVO
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BU of 6qvo by Molmil
Crystal structure of human MTH1 in complex with N6-methyl-dAMP
Descriptor: 7,8-dihydro-8-oxoguanine triphosphatase, GLYCEROL, N6-METHYL-DEOXY-ADENOSINE-5'-MONOPHOSPHATE, ...
Authors:Scaletti, E, Vallin, K.S, Brautigam, L, Sarno, A, Warpman Berglund, U, Helleday, T, Stenmark, P, Jemth, A.S.
Deposit date:2019-03-04
Release date:2020-03-18
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool.
J.Biol.Chem., 295, 2020
8PTT
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BU of 8ptt by Molmil
Human NUDT5 in complex with MRK-952
Descriptor: 6-[(5~{R})-7-[3-chloranyl-4-(trifluoromethyl)phenyl]-2,7-diazaspiro[4.4]nonan-2-yl]-7-methyl-purine, ADP-sugar pyrophosphatase, MAGNESIUM ION
Authors:Diaz-Saez, L, Koekemoer, L, Feyerherm, C, Sloman, S, Fischer, C, Schneider, S, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Huber, K.V.M.
Deposit date:2023-07-14
Release date:2024-07-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Human NUDT5 in complex with MRK-952
To Be Published
3L85
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BU of 3l85 by Molmil
Crystal structure of human NUDT5 complexed with 8-oxo-dGMP
Descriptor: 8-OXO-2'-DEOXY-GUANOSINE-5'-MONOPHOSPHATE, ADP-sugar pyrophosphatase
Authors:Arimori, T, Yamagata, Y.
Deposit date:2009-12-29
Release date:2011-01-12
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.301 Å)
Cite:Diverse substrate recognition and hydrolysis mechanisms of human NUDT5
Nucleic Acids Res., 39, 2011
3MCF
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BU of 3mcf by Molmil
Crystal structure of human diphosphoinositol polyphosphate phosphohydrolase 3-alpha
Descriptor: CITRATE ANION, Diphosphoinositol polyphosphate phosphohydrolase 3-alpha, GLYCEROL
Authors:Tresaugues, L, Welin, M, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, I, Karlberg, T, Kol, S, Kotenyova, T, Moche, M, Nyman, T, Persson, C, Schuler, H, Schutz, P, Siponen, M.I, Thorsell, A.G, van der Berg, S, Wahlberg, E, Weigelt, J, Wisniewska, M, Nordlund, P, Structural Genomics Consortium (SGC)
Deposit date:2010-03-29
Release date:2010-04-07
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of human diphosphoinositol polyphosphate phosphohydrolase 3-alpha
To be Published
4DYW
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BU of 4dyw by Molmil
Crystal structure of MutT NUDIX hydrolase from Burkholderia pseudomallei
Descriptor: MutT/NUDIX family protein
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2012-02-29
Release date:2012-04-11
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of MutT NUDIX hydrolase from Burkholderia pseudomallei
To be Published
7R0D
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BU of 7r0d by Molmil
Structure of NUDT15 in complex with Geranyl monophosphate
Descriptor: Geranyl phosphate, MAGNESIUM ION, Probable 8-oxo-dGTP diphosphatase NUDT15
Authors:Scaletti, E.R, Stenmark, P.
Deposit date:2022-02-01
Release date:2023-11-29
Last modified:2024-09-04
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Kinetic and structural characterization of NUDT15 and NUDT18 as catalysts of isoprene pyrophosphate hydrolysis.
Febs J., 2024
6IMZ
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BU of 6imz by Molmil
Crystal structure of MTH1 in complex with 18-Crown-6
Descriptor: 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-amine, 7,8-dihydro-8-oxoguanine triphosphatase, ...
Authors:Yokoyama, T, Kosaka, Y, Matsumoto, K, Kitakami, R, Nabeshima, Y, Mizuguchi, M.
Deposit date:2018-10-24
Release date:2019-10-30
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crown Ethers as Transthyretin Amyloidogenesis Inhibitor
To Be Published
6PCK
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BU of 6pck by Molmil
Crystal structure of human diphosphoinositol polyphosphate phosphohydrolase 1 in complex with 1-IP7
Descriptor: (1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentakis(phosphonooxy)cyclohexyl trihydrogen diphosphate, CHLORIDE ION, Diphosphoinositol polyphosphate phosphohydrolase 1, ...
Authors:Dollins, D.E, Neubauer, J, Dong, J, York, J.D.
Deposit date:2019-06-17
Release date:2020-04-29
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Vip1 is a kinase and pyrophosphatase switch that regulates inositol diphosphate signaling.
Proc.Natl.Acad.Sci.USA, 117, 2020
6P5R
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BU of 6p5r by Molmil
Structure of T. brucei MERS1-GDP complex
Descriptor: GUANOSINE-5'-DIPHOSPHATE, Mitochondrial edited mRNA stability factor 1
Authors:Schumacher, M.A.
Deposit date:2019-05-30
Release date:2019-11-06
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structures of MERS1, the 5' processing enzyme of mitochondrial mRNAs inTrypanosoma brucei.
Rna, 26, 2020
6ILI
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BU of 6ili by Molmil
Crystal structure of human MTH1(G2K/D120N mutant) in complex with 8-oxo-dGTP at pH 6.5
Descriptor: 7,8-dihydro-8-oxoguanine triphosphatase, 8-OXO-2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE
Authors:Nakamura, T, Waz, S, Hirata, K, Nakabeppu, Y, Yamagata, Y.
Deposit date:2018-10-18
Release date:2018-11-07
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structural and Kinetic Studies of the Human Nudix Hydrolase MTH1 Reveal the Mechanism for Its Broad Substrate Specificity
J. Biol. Chem., 292, 2017
7SEZ
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BU of 7sez by Molmil
Crystal structure of Vaccinia Virus decapping enzyme D9 in complex with m7GDP
Descriptor: 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE, DNA repair NTP-phosphohydrolase, SODIUM ION
Authors:Peters, J.K, Tibble, R.W, Warminski, M, Jemielity, J, Gross, J.D.
Deposit date:2021-10-02
Release date:2022-03-30
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.70001245 Å)
Cite:Structure of the poxvirus decapping enzyme D9 reveals its mechanism of cap recognition and catalysis.
Structure, 30, 2022
7SF0
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BU of 7sf0 by Molmil
Crystal structure of Vaccinia Virus decapping enzyme D9 in complex with trinucleotide substrate
Descriptor: 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE, DNA repair NTP-phosphohydrolase, MAGNESIUM ION, ...
Authors:Peters, J.K, Tibble, R.W, Warminski, M, Jemielity, J, Gross, J.D.
Deposit date:2021-10-02
Release date:2022-03-30
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.95000446 Å)
Cite:Structure of the poxvirus decapping enzyme D9 reveals its mechanism of cap recognition and catalysis.
Structure, 30, 2022
6IJY
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BU of 6ijy by Molmil
Crystal structure of human MTH1(G2K/C87A/C104S mutant) in complex with 8-oxo-dGTP determined using a crystal obtained under microgravity
Descriptor: 7,8-dihydro-8-oxoguanine triphosphatase, 8-OXO-2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, GLYCEROL, ...
Authors:Nakamura, T, Yamagata, Y.
Deposit date:2018-10-12
Release date:2019-02-20
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.04 Å)
Cite:X-ray Structure Analysis of Human Oxidized Nucleotide Hydrolase MTH1 using Crystals Obtained under Microgravity.
Int. J. Microgravity Sci. Appl., 36, 2019
6PCL
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BU of 6pcl by Molmil
Crystal structure of human diphosphoinositol polyphosphate phosphohydrolase 1 in complex with 5-IP7
Descriptor: (1r,2R,3S,4s,5R,6S)-2,3,4,5,6-pentakis(phosphonooxy)cyclohexyl trihydrogen diphosphate, CHLORIDE ION, Diphosphoinositol polyphosphate phosphohydrolase 1, ...
Authors:Dollins, D.E, Neubauer, J, Dong, J, York, J.D.
Deposit date:2019-06-17
Release date:2020-04-29
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Vip1 is a kinase and pyrophosphatase switch that regulates inositol diphosphate signaling.
Proc.Natl.Acad.Sci.USA, 117, 2020
7T7H
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BU of 7t7h by Molmil
Crystal structure of Vaccinia Virus decapping enzyme D9 in complex with inhibitor CP100356
Descriptor: 4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-6,7-dimethoxyquinazolin-2-amine, DNA repair NTP-phosphohydrolase, SODIUM ION
Authors:Peters, J.K, Gross, J.D.
Deposit date:2021-12-15
Release date:2022-06-15
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.78000259 Å)
Cite:Fluorescence-Based Activity Screening Assay Reveals Small Molecule Inhibitors of Vaccinia Virus mRNA Decapping Enzyme D9.
Acs Chem.Biol., 17, 2022
3U53
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BU of 3u53 by Molmil
Crystal structure of human Ap4A hydrolase
Descriptor: Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical], GLYCEROL, SULFATE ION
Authors:Ge, H.H, Teng, M.K.
Deposit date:2011-10-10
Release date:2012-10-10
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.705 Å)
Cite:Crystal structure of wild-type and mutant human Ap4A hydrolase
Biochem.Biophys.Res.Commun., 432, 2013
3SHD
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BU of 3shd by Molmil
Crystal structure of Nudix hydrolase Orf153, ymfB, from Escherichia coli K-1
Descriptor: MANGANESE (II) ION, Phosphatase nudJ, SULFATE ION
Authors:Hong, M.K, Kim, J.K, Kang, L.W.
Deposit date:2011-06-16
Release date:2012-06-27
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure and atypical hydrolysis mechanism of the Nudix hydrolase Orf153 (YmfB) from Escherichia coli
To be Published
3SMD
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BU of 3smd by Molmil
Crystal structure of a mut/nudix family protein from bacillus thuringiensis
Descriptor: MutT/NUDIX family protein
Authors:Palani, K, Kumaran, D, Burley, S.K, Swaminathan, S, New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2011-06-27
Release date:2011-07-20
Last modified:2021-02-10
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Crystal structure of a mut/nudix family protein from bacillus thuringiensis
To be Published
8DPA
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BU of 8dpa by Molmil
Crystal structure of the homodimeric AvrM14-B Nudix hydrolase effector from Melampsora lini
Descriptor: AvrM14-B, SULFATE ION
Authors:McCombe, C.L, Outram, M.A, Ericsson, D.J, Williams, S.J.
Deposit date:2022-07-15
Release date:2023-01-25
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:A rust-fungus Nudix hydrolase effector decaps mRNA in vitro and interferes with plant immune pathways.
New Phytol., 239, 2023
8DP9
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BU of 8dp9 by Molmil
Crystal structure of the monomeric AvrM14-B Nudix hydrolase effector from Melampsora lini
Descriptor: AvrM14-B, SULFATE ION
Authors:McCombe, C.L, Outram, M.A, Ericsson, D.J, Williams, S.J.
Deposit date:2022-07-15
Release date:2023-01-25
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:A rust-fungus Nudix hydrolase effector decaps mRNA in vitro and interferes with plant immune pathways.
New Phytol., 239, 2023
8DP8
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BU of 8dp8 by Molmil
Crystal structure of the monomeric AvrM14-A Nudix hydrolase effector from Melampsora lini
Descriptor: AvrM14-A
Authors:McCombe, C.L, Outram, M.A, Ericsson, D.J, Williams, S.J.
Deposit date:2022-07-15
Release date:2023-01-25
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.30001 Å)
Cite:A rust-fungus Nudix hydrolase effector decaps mRNA in vitro and interferes with plant immune pathways.
New Phytol., 239, 2023

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