8BGJ
| |
4XO0
| |
4XPC
| |
1QAI
| CRYSTAL STRUCTURES OF THE N-TERMINAL FRAGMENT FROM MOLONEY MURINE LEUKEMIA VIRUS REVERSE TRANSCRIPTASE COMPLEXED WITH NUCLEIC ACID: FUNCTIONAL IMPLICATIONS FOR TEMPLATE-PRIMER BINDING TO THE FINGERS DOMAIN | Descriptor: | DNA (5'-D(*CP*AP*TP*GP*CP*AP*TP*G)-3'), MERCURY (II) ION, REVERSE TRANSCRIPTASE | Authors: | Najmudin, S, Cote, M, Sun, D, Yohannan, S, Montano, S.P, Gu, J, Georgiadis, M.M. | Deposit date: | 1999-03-12 | Release date: | 2000-03-20 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structures of an N-terminal fragment from Moloney murine leukemia virus reverse transcriptase complexed with nucleic acid: functional implications for template-primer binding to the fingers domain. J.Mol.Biol., 296, 2000
|
|
4XPE
| |
8QBM
| |
8QBL
| |
8QBK
| |
1ZTT
| Netropsin bound to d(CTTAATTCGAATTAAG) in complex with MMLV RT catalytic fragment | Descriptor: | 5'-D(*CP*TP*TP*AP*AP*TP*TP*C)-3', 5'-D(P*GP*AP*AP*TP*TP*AP*AP*G)-3', NETROPSIN, ... | Authors: | Goodwin, K.D, Long, E.C, Georgiadis, M.M. | Deposit date: | 2005-05-27 | Release date: | 2005-08-30 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | A host-guest approach for determining drug-DNA interactions: an example using netropsin. Nucleic Acids Res., 33, 2005
|
|
1ZTW
| |
8C8J
| Long Interspersed Nuclear Element 1 (LINE-1) reverse transcriptase ternary complex with hybrid duplex and dTTP | Descriptor: | 1,2-ETHANEDIOL, 1,4-DIETHYLENE DIOXIDE, CHLORIDE ION, ... | Authors: | Nichols, C.E, Walpole, T.B, Baldwin, E. | Deposit date: | 2023-01-20 | Release date: | 2023-12-20 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structures, functions and adaptations of the human LINE-1 ORF2 protein. Nature, 626, 2024
|
|
8CS0
| |
8DW1
| Crystal structure of a host-guest complex with 5'-CTTAGTTATAACTAAG-3' | Descriptor: | DNA (5'-D(*CP*TP*TP*AP*GP*TP*TP*A)-3'), DNA (5'-D(P*TP*AP*AP*CP*TP*AP*AP*G)-3'), reverse transcriptase | Authors: | Georgiadis, M.M. | Deposit date: | 2022-07-30 | Release date: | 2023-01-11 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.849 Å) | Cite: | Two distinct rotations of bithiazole DNA intercalation revealed by direct comparison of crystal structures of Co(III)•bleomycin A 2 and B 2 bound to duplex 5'-TAGTT sites. Bioorg.Med.Chem., 77, 2023
|
|
8DWM
| Host-guest complex of bleomycin A2 fully bound to CTTAGTTATAACTAAG | Descriptor: | BLEOMYCIN A2, COBALT (III) ION, DNA (5'-D(*CP*TP*TP*AP*GP*TP*TP*A)-3'), ... | Authors: | Georgiadis, M.M. | Deposit date: | 2022-08-01 | Release date: | 2023-01-11 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.99 Å) | Cite: | Two distinct rotations of bithiazole DNA intercalation revealed by direct comparison of crystal structures of Co(III)•bleomycin A 2 and B 2 bound to duplex 5'-TAGTT sites. Bioorg.Med.Chem., 77, 2023
|
|
8DW8
| Host-guest structure of BLMA2 partially bound to 5'-ATTAGTTATAACTAAT-3' | Descriptor: | BLEOMYCIN A2, DNA (5'-D(*AP*TP*TP*AP*GP*TP*TP*A)-3'), DNA (5'-D(P*TP*AP*AP*CP*TP*AP*AP*T)-3'), ... | Authors: | Georgiadis, M.M. | Deposit date: | 2022-07-31 | Release date: | 2023-01-11 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.58 Å) | Cite: | Two distinct rotations of bithiazole DNA intercalation revealed by direct comparison of crystal structures of Co(III)•bleomycin A 2 and B 2 bound to duplex 5'-TAGTT sites. Bioorg.Med.Chem., 77, 2023
|
|
8GH6
| |
8IBX
| Structure of R2 with 3'UTR and DNA in unwinding state | Descriptor: | 3'UTR, DNA (60-MER), Reverse transcriptase-like protein, ... | Authors: | Deng, P, Tan, S, Wang, J, Liu, J.J. | Deposit date: | 2023-02-10 | Release date: | 2023-09-20 | Method: | ELECTRON MICROSCOPY (3.74 Å) | Cite: | Structural RNA components supervise the sequential DNA cleavage in R2 retrotransposon. Cell, 186, 2023
|
|
8IBW
| Structure of R2 with 3'UTR and DNA in binding state | Descriptor: | 3'UTR, DNA (60-MER), Reverse transcriptase-like protein, ... | Authors: | Deng, P, Tan, S, Wang, J, Liu, J.J. | Deposit date: | 2023-02-10 | Release date: | 2023-09-20 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structural RNA components supervise the sequential DNA cleavage in R2 retrotransposon. Cell, 186, 2023
|
|
8IBZ
| Structure of R2 with 5'ORF and 3'UTR | Descriptor: | 5ORF-linker-3UTR, Reverse transcriptase-like protein, ZINC ION | Authors: | Deng, P, Tan, S, Wang, J, Liu, J.J. | Deposit date: | 2023-02-10 | Release date: | 2023-09-20 | Method: | ELECTRON MICROSCOPY (3.04 Å) | Cite: | Structural RNA components supervise the sequential DNA cleavage in R2 retrotransposon. Cell, 186, 2023
|
|
8IBY
| Structure of R2 with 5'ORF | Descriptor: | 5'ORF RNA, Reverse transcriptase-like protein, ZINC ION | Authors: | Deng, P, Tan, S, Wang, J, Liu, J.J. | Deposit date: | 2023-02-10 | Release date: | 2023-09-20 | Method: | ELECTRON MICROSCOPY (3.47 Å) | Cite: | Structural RNA components supervise the sequential DNA cleavage in R2 retrotransposon. Cell, 186, 2023
|
|
2FJV
| RT29 Bound to D(CTTAATTCGAATTAAG) in complex with MMLV RT Catalytic Fragment | Descriptor: | 2-(4-(4-CARBAMIMIDOYLPHENOXY)PHENYL)-1H-BENZO[D]IMIDAZOLE-6-CARBOXIMIDAMIDE, 5'-D(*CP*TP*TP*AP*AP*TP*TP*C)-3', 5'-D(P*GP*AP*AP*TP*TP*AP*AP*G)-3', ... | Authors: | Goodwin, K.D, Georgiadis, M.M. | Deposit date: | 2006-01-03 | Release date: | 2006-06-27 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | A High-Throughput, High-Resolution Strategy for the Study of Site-Selective DNA Binding Agents: Analysis of a "Highly Twisted" Benzimidazole-Diamidine. J.Am.Chem.Soc., 128, 2006
|
|
2FJX
| RT29 bound to D(CTTGAATGCATTCAAG) in complex with MMLV RT catalytic fragment | Descriptor: | 2-(4-(4-CARBAMIMIDOYLPHENOXY)PHENYL)-1H-BENZO[D]IMIDAZOLE-6-CARBOXIMIDAMIDE, 5'-D(*CP*TP*TP*GP*AP*AP*TP*G)-3', 5'-D(P*CP*AP*TP*TP*CP*AP*AP*G)-3', ... | Authors: | Goodwin, K.D, Georgiadis, M.M. | Deposit date: | 2006-01-03 | Release date: | 2006-06-27 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | A High-Throughput, High-Resolution Strategy for the Study of Site-Selective DNA Binding Agents: Analysis of a "Highly Twisted" Benzimidazole-Diamidine. J.Am.Chem.Soc., 128, 2006
|
|
7R08
| Abortive infection DNA polymerase Abi-P2 | Descriptor: | Reverse transcriptase | Authors: | Gapinska, M.A, Figiel, M, Czarnocki Cieciura, M, Nowotny, M, Zajko, W. | Deposit date: | 2022-02-01 | Release date: | 2022-09-07 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Mechanism of protein-primed template-independent DNA synthesis by Abi polymerases. Nucleic Acids Res., 50, 2022
|
|
7R06
| Abortive infection DNA polymerase AbiK from Lactococcus lactis | Descriptor: | AbiK, DNA (5'-D(*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*C)-3') | Authors: | Figiel, M, Nowotny, M, Gapinska, M, Czarnocki-Cieciura, M, Zajko, W. | Deposit date: | 2022-02-01 | Release date: | 2022-09-07 | Last modified: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (2.27 Å) | Cite: | Mechanism of protein-primed template-independent DNA synthesis by Abi polymerases. Nucleic Acids Res., 50, 2022
|
|
7R07
| Abortive infection DNA polymerase AbiK from Lactococcus lactis | Descriptor: | AbiK, DNA (5'-D(*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*C)-3'), MAGNESIUM ION | Authors: | Figiel, M, Gapinska, M, Czarnocki-Cieciura, M, Zajko, W, Nowotny, M. | Deposit date: | 2022-02-01 | Release date: | 2022-09-07 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Mechanism of protein-primed template-independent DNA synthesis by Abi polymerases. Nucleic Acids Res., 50, 2022
|
|