7ESF
 
 | | The Crystal Structure of human MTH1 from Biortus | | 分子名称: | 7,8-dihydro-8-oxoguanine triphosphatase, DI(HYDROXYETHYL)ETHER, TETRAETHYLENE GLYCOL | | 著者 | Wang, F, Cheng, W, Shang, H, Wang, R, Zhang, B, Tian, F. | | 登録日 | 2021-05-10 | | 公開日 | 2021-05-26 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | The Crystal Structure of human MTH1 from Biortus
To Be Published
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7R0D
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6QVO
 | | Crystal structure of human MTH1 in complex with N6-methyl-dAMP | | 分子名称: | 7,8-dihydro-8-oxoguanine triphosphatase, GLYCEROL, N6-METHYL-DEOXY-ADENOSINE-5'-MONOPHOSPHATE, ... | | 著者 | Scaletti, E, Vallin, K.S, Brautigam, L, Sarno, A, Warpman Berglund, U, Helleday, T, Stenmark, P, Jemth, A.S. | | 登録日 | 2019-03-04 | | 公開日 | 2020-03-18 | | 最終更新日 | 2020-09-30 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool.
J.Biol.Chem., 295, 2020
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8DP8
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8DPA
 | | Crystal structure of the homodimeric AvrM14-B Nudix hydrolase effector from Melampsora lini | | 分子名称: | AvrM14-B, SULFATE ION | | 著者 | McCombe, C.L, Outram, M.A, Ericsson, D.J, Williams, S.J. | | 登録日 | 2022-07-15 | | 公開日 | 2023-01-25 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | | 主引用文献 | A rust-fungus Nudix hydrolase effector decaps mRNA in vitro and interferes with plant immune pathways.
New Phytol., 239, 2023
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8DP9
 | | Crystal structure of the monomeric AvrM14-B Nudix hydrolase effector from Melampsora lini | | 分子名称: | AvrM14-B, SULFATE ION | | 著者 | McCombe, C.L, Outram, M.A, Ericsson, D.J, Williams, S.J. | | 登録日 | 2022-07-15 | | 公開日 | 2023-01-25 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | | 主引用文献 | A rust-fungus Nudix hydrolase effector decaps mRNA in vitro and interferes with plant immune pathways.
New Phytol., 239, 2023
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6T5J
 | | Structure of NUDT15 in complex with inhibitor TH1760 | | 分子名称: | 6-[4-(1~{H}-indol-5-ylcarbonyl)piperazin-1-yl]sulfonyl-3~{H}-1,3-benzoxazol-2-one, CHLORIDE ION, MAGNESIUM ION, ... | | 著者 | Carter, M, Rehling, D, Desroses, M, Zhang, S.M, Hagenkort, A, Valerie, N.C.K, Helleday, T, Stenmark, P. | | 登録日 | 2019-10-16 | | 公開日 | 2020-07-29 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Development of a chemical probe against NUDT15.
Nat.Chem.Biol., 16, 2020
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3ZR1
 | | Crystal structure of human MTH1 | | 分子名称: | 7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE, ACETATE ION, SULFATE ION | | 著者 | Svensson, L.M, Jemth, A, Desroses, M, Loseva, O, Helleday, T, Hogbom, M, Stenmark, P. | | 登録日 | 2011-06-13 | | 公開日 | 2011-07-27 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Crystal Structure of Human Mth1 and the 8-Oxo-Dgmp Product Complex.
FEBS Lett., 585, 2011
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7N13
 | | Crystal structure of MTH1 in complex with compound 32 | | 分子名称: | 4-anilino-6-[4-(butylcarbamoyl)-3-fluorophenyl]-N-cyclopropyl-7-fluoroquinoline-3-carboxamide, 7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION | | 著者 | Eron, S.J. | | 登録日 | 2021-05-26 | | 公開日 | 2021-11-03 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | | 主引用文献 | Development of an AchillesTAG degradation system and its application to control CAR-T activity
Curr Res Chem Biol, 1, 2021
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7N03
 | | Crystal structure of MTH1 in complex with compound 31 | | 分子名称: | 4-anilino-6-(hexylamino)-N-methylquinoline-3-carboxamide, 7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION | | 著者 | Eron, S.J. | | 登録日 | 2021-05-24 | | 公開日 | 2021-11-03 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.13 Å) | | 主引用文献 | Development of an AchillesTAG degradation system and its application to control CAR-T activity
Curr Res Chem Biol, 1, 2021
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4S2W
 | | Structure of E. coli RppH bound to sulfate ions | | 分子名称: | RNA pyrophosphohydrolase, SULFATE ION | | 著者 | Vasilyev, N, Serganov, A. | | 登録日 | 2015-01-23 | | 公開日 | 2015-02-11 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.992 Å) | | 主引用文献 | Structures of RNA Complexes with the Escherichia coli RNA Pyrophosphohydrolase RppH Unveil the Basis for Specific 5'-End-dependent mRNA Decay.
J.Biol.Chem., 290, 2015
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7NNJ
 | | Crystal Structure of NUDT4 (Diphosphoinositol polyphosphate phosphohydrolase 2) in complex with 4-O-Bn-1-PCP-InsP4 (AMR2105) | | 分子名称: | 1,2-ETHANEDIOL, Diphosphoinositol polyphosphate phosphohydrolase 2, FORMIC ACID, ... | | 著者 | Dubianok, Y, Arruda Bezerra, G, Raux, B, Diaz Saez, L, Riley, A.M, Potter, B.V.L, Huber, K.V.M, von Delft, F. | | 登録日 | 2021-02-24 | | 公開日 | 2022-03-23 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.755 Å) | | 主引用文献 | Crystal Structure of NUDT4 (Diphosphoinositol polyphosphate phosphohydrolase 2) in complex with 4-O-Bn-1-PCP-InsP4 (AMR2105)
To Be Published
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7NR6
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4S2X
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4S2Y
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4S2V
 | | E. coli RppH structure, KI soak | | 分子名称: | ACETATE ION, CALCIUM ION, IODIDE ION, ... | | 著者 | Vasilyev, N, Serganov, A. | | 登録日 | 2015-01-23 | | 公開日 | 2015-02-11 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Structures of RNA Complexes with the Escherichia coli RNA Pyrophosphohydrolase RppH Unveil the Basis for Specific 5'-End-dependent mRNA Decay.
J.Biol.Chem., 290, 2015
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1F3Y
 | | SOLUTION STRUCTURE OF THE NUDIX ENZYME DIADENOSINE TETRAPHOSPHATE HYDROLASE FROM LUPINUS ANGUSTIFOLIUS L. | | 分子名称: | DIADENOSINE 5',5'''-P1,P4-TETRAPHOSPHATE HYDROLASE | | 著者 | Swarbrick, J.D, Bashtannyk, T, Maksel, D, Zhang, X.R, Blackburn, G.M, Gayler, K.R, Gooley, P.R. | | 登録日 | 2000-06-06 | | 公開日 | 2001-06-06 | | 最終更新日 | 2021-11-10 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The three-dimensional structure of the Nudix enzyme diadenosine tetraphosphate hydrolase from Lupinus angustifolius L.
J.Mol.Biol., 302, 2000
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4C9X
 | | Crystal structure of NUDT1 (MTH1) with S-crizotinib | | 分子名称: | 3-[(1S)-1-(2,6-DICHLORO-3-FLUOROPHENYL)ETHOXY]-5-(1-PIPERIDIN-4-YLPYRAZOL-4-YL)PYRIDIN-2-AMINE, 7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE, CHLORIDE ION, ... | | 著者 | Elkins, J.M, Salah, E, Huber, K, Superti-Furga, G, Abdul Azeez, K.R, Krojer, T, von Delft, F, Bountra, C, Edwards, A, Knapp, S. | | 登録日 | 2013-10-03 | | 公開日 | 2014-04-02 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | Stereospecific Targeting of Mth1 by (S)-Crizotinib as an Anticancer Strategy.
Nature, 508, 2014
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4C9W
 | | Crystal structure of NUDT1 (MTH1) with R-crizotinib | | 分子名称: | 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-amine, 7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE, CHLORIDE ION, ... | | 著者 | Elkins, J.M, Salah, E, Huber, K, Superti-Furga, G, Abdul Azeez, K.R, Raynor, J, Krojer, T, von Delft, F, Bountra, C, Edwards, A, Knapp, S. | | 登録日 | 2013-10-03 | | 公開日 | 2014-04-02 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Stereospecific Targeting of Mth1 by (S)-Crizotinib as an Anticancer Strategy.
Nature, 508, 2014
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1G0S
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1GA7
 | | CRYSTAL STRUCTURE OF THE ADP-RIBOSE PYROPHOSPHATASE IN COMPLEX WITH GD+3 | | 分子名称: | GADOLINIUM ION, HYPOTHETICAL 23.7 KDA PROTEIN IN ICC-TOLC INTERGENIC REGION | | 著者 | Gabelli, S.B, Bianchet, M.A, Bessman, M.J, Amzel, L.M. | | 登録日 | 2000-11-29 | | 公開日 | 2001-05-02 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.71 Å) | | 主引用文献 | The structure of ADP-ribose pyrophosphatase reveals the structural basis for the versatility of the Nudix family.
Nat.Struct.Biol., 8, 2001
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1G9Q
 | | COMPLEX STRUCTURE OF THE ADPR-ASE AND ITS SUBSTRATE ADP-RIBOSE | | 分子名称: | ADENOSINE-5-DIPHOSPHORIBOSE, HYPOTHETICAL 23.7 KDA PROTEIN IN ICC-TOLC INTERGENIC REGION | | 著者 | Gabelli, S.B, Bianchet, M.A, Bessman, M.J, Amzel, L.M. | | 登録日 | 2000-11-27 | | 公開日 | 2001-05-02 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | The structure of ADP-ribose pyrophosphatase reveals the structural basis for the versatility of the Nudix family.
Nat.Struct.Biol., 8, 2001
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4DYW
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7SP3
 | | E. coli RppH bound to Ap4A | | 分子名称: | BIS(ADENOSINE)-5'-TETRAPHOSPHATE, CHLORIDE ION, FLUORIDE ION, ... | | 著者 | Serganov, A.A, Vasilyev, N, Nuthanakanti, A. | | 登録日 | 2021-11-02 | | 公開日 | 2022-03-09 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | A distinct RNA recognition mechanism governs Np 4 decapping by RppH.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7SEZ
 | | Crystal structure of Vaccinia Virus decapping enzyme D9 in complex with m7GDP | | 分子名称: | 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE, DNA repair NTP-phosphohydrolase, SODIUM ION | | 著者 | Peters, J.K, Tibble, R.W, Warminski, M, Jemielity, J, Gross, J.D. | | 登録日 | 2021-10-02 | | 公開日 | 2022-03-30 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.70001245 Å) | | 主引用文献 | Structure of the poxvirus decapping enzyme D9 reveals its mechanism of cap recognition and catalysis.
Structure, 30, 2022
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