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1AFW
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THE 1.8 ANGSTROM CRYSTAL STRUCTURE OF THE DIMERIC PEROXISOMAL THIOLASE OF SACCHAROMYCES CEREVISIAE
分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, 3-KETOACETYL-COA THIOLASE
著者Mathieu, M, Wierenga, R.K.
登録日1997-03-15
公開日1997-06-16
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献The 1.8 A crystal structure of the dimeric peroxisomal 3-ketoacyl-CoA thiolase of Saccharomyces cerevisiae: implications for substrate binding and reaction mechanism.
J.Mol.Biol., 273, 1997
6PCD
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Crystal structure of beta-ketoadipyl-CoA thiolase mutant (C90S-H356A) in complex Octanoyl coenzyme A
分子名称: Beta-ketoadipyl-CoA thiolase, CHLORIDE ION, COENZYME A, ...
著者Sukritee, B, Panjikar, S.
登録日2019-06-17
公開日2020-05-27
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.37 Å)
主引用文献Structural basis for differentiation between two classes of thiolase: Degradative vs biosynthetic thiolase.
J Struct Biol X, 4, 2020
1QFL
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BIOSYNTHETIC THIOLASE FROM ZOOGLOEA RAMIGERA IN COMPLEX WITH A REACTION INTERMEDIATE.
分子名称: COENZYME A, PROTEIN (ACETOACETYL-COA THIOLASE), SULFATE ION
著者Modis, Y, Wierenga, R.K.
登録日1999-04-12
公開日2000-04-19
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.92 Å)
主引用文献A biosynthetic thiolase in complex with a reaction intermediate: the crystal structure provides new insights into the catalytic mechanism.
Structure Fold.Des., 7, 1999
3GOA
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BU of 3goa by Molmil
Crystal structure of the Salmonella typhimurium FadA 3-ketoacyl-CoA thiolase
分子名称: 3-ketoacyl-CoA thiolase, CALCIUM ION, CHLORIDE ION, ...
著者Anderson, S.M, Skarina, T, Onopriyenko, O, Wawrzak, Z, Papazisi, L, Savchenko, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2009-03-18
公開日2009-03-31
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献

5MG5
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BU of 5mg5 by Molmil
A multi-component acyltransferase PhlABC from Pseudomonas protegens soaked with the monoacetylphloroglucinol (MAPG)
分子名称: 2,4-diacetylphloroglucinol biosynthesis protein, 2,4-diacetylphloroglucinol biosynthesis protein PhlC, Hydroxymethylglutaryl-CoA synthase, ...
著者Pavkov-Keller, T, Schmidt, N.G, Kroutil, W, Gruber, K.
登録日2016-11-20
公開日2017-12-20
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (3.44 Å)
主引用文献Structure and Catalytic Mechanism of a Bacterial Friedel-Crafts Acylase.
Chembiochem, 20, 2019
7FEA
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PY14 in complex with Col-D
分子名称: (6~{R},7~{R},9~{E})-6,7-bis(oxidanyl)hexadeca-9,15-dien-11,13-diynoic acid, Acetyl-CoA C-acyltransferase
著者Lin, C.C, Ko, T.P, Huang, K.F, Yang, Y.L.
登録日2021-07-19
公開日2022-07-27
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Integrated omics approach to unveil antifungal bacterial polyynes as acetyl-CoA acetyltransferase inhibitors.
Commun Biol, 5, 2022
6OK1
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Ltp2-ChsH2(DUF35) aldolase
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, ChsH2(DUF35), ...
著者Kimber, M.S, Mallette, E, Aggett, R, Seah, S.Y.K.
登録日2019-04-12
公開日2019-06-26
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献The steroid side-chain-cleaving aldolase Ltp2-ChsH2DUF35is a thiolase superfamily member with a radically repurposed active site.
J.Biol.Chem., 294, 2019
5ONC
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Catabolism of the Cholesterol Side Chain in Mycobacterium tuberculosis is Controlled by a Redox-Sensitive Thiol Switch
分子名称: CHLORIDE ION, Steroid 3-ketoacyl-CoA thiolase
著者Schaefer, C, Kuper, J, Sampson, N.S, Kisker, C.
登録日2017-08-03
公開日2017-08-23
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.19 Å)
主引用文献Catabolism of the Cholesterol Side Chain in Mycobacterium tuberculosis Is Controlled by a Redox-Sensitive Thiol Switch.
ACS Infect Dis, 3, 2017
1ULQ
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Crystal structure of tt0182 from Thermus thermophilus HB8
分子名称: putative acetyl-CoA acetyltransferase
著者Ago, H, Hamada, K, Ida, K, Kanda, H, Sugahara, M, Yamamoto, M, Kuroishi, C, Kuramitsu, S, Yokoyama, S, Miyano, M, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2003-09-16
公開日2004-11-02
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Crystal structure of tt0182 from Thermus thermophilus HB8
To be Published
1M3Z
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Biosynthetic thiolase, C89A mutant, complexed with acetyl coenzyme A
分子名称: ACETYL COENZYME *A, Acetyl-CoA acetyltransferase, SULFATE ION
著者Kursula, P, Ojala, J, Lambeir, A.-M, Wierenga, R.K.
登録日2002-07-03
公開日2002-11-29
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.87 Å)
主引用文献The catalytic cycle of biosynthetic thiolase: A conformational journey of an acetyl group through four binding modes and two oxyanion holes
Biochemistry, 41, 2002
4XL2
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Crystal structure of oxidized form of thiolase from Clostridium acetobutylicum
分子名称: ACETATE ION, Acetyl-CoA acetyltransferase, DI(HYDROXYETHYL)ETHER, ...
著者Kim, S, Ha, S.C, Ahn, J.W, Kim, E.J, Lim, J.H, Kim, K.J.
登録日2015-01-13
公開日2015-10-07
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献Redox-switch regulatory mechanism of thiolase from Clostridium acetobutylicum
Nat Commun, 6, 2015
7PXP
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BU of 7pxp by Molmil
Benzoylsuccinyl-CoA thiolase
分子名称: Benzoylsuccinyl-CoA thiolase subunit, ZINC ION
著者Ermler, U, Heider, H, Weidenweber, S, Demmer, U.
登録日2021-10-08
公開日2022-04-06
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Finis tolueni: a new type of thiolase with an integrated Zn-finger subunit catalyzes the final step of anaerobic toluene metabolism.
Febs J., 289, 2022
6ESQ
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Structure of the acetoacetyl-CoA thiolase/HMG-CoA synthase complex from Methanothermococcus thermolithotrophicus soaked with acetyl-CoA
分子名称: CHLORIDE ION, COENZYME A, HydroxyMethylGlutaryl-CoA synthase, ...
著者Voegeli, B, Engilberge, S, Girard, E, Riobe, F, Maury, O, Erb, J.T, Shima, S, Wagner, T.
登録日2017-10-24
公開日2018-03-14
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.95 Å)
主引用文献Archaeal acetoacetyl-CoA thiolase/HMG-CoA synthase complex channels the intermediate via a fused CoA-binding site.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
7PYT
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BU of 7pyt by Molmil
Benzoylsuccinyl-CoA thiolase with coenzyme A
分子名称: 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Benzoylsuccinyl-CoA thiolase subunit, ...
著者Ermler, U, Heider, J, Weidenweber, S, Demmer, U.
登録日2021-10-11
公開日2022-04-06
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Finis tolueni: a new type of thiolase with an integrated Zn-finger subunit catalyzes the final step of anaerobic toluene metabolism.
Febs J., 289, 2022
4XL3
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BU of 4xl3 by Molmil
Crystal structure of reduced form of thiolase from Clostridium acetobutylicum
分子名称: Acetyl-CoA acetyltransferase, GLYCEROL
著者Kim, S, Ha, S.C, Ahn, J.W, Kim, E.J, Lim, J.H, Kim, K.J.
登録日2015-01-13
公開日2015-10-07
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Redox-switch regulatory mechanism of thiolase from Clostridium acetobutylicum
Nat Commun, 6, 2015
6ET9
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BU of 6et9 by Molmil
Structure of the acetoacetyl-CoA-thiolase/HMG-CoA-synthase complex from Methanothermococcus thermolithotrophicus at 2.75 A
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Acetyl-CoA acetyltransferase thiolase, CHLORIDE ION, ...
著者Engilberge, S, Voegeli, B, Girard, E, Riobe, F, Maury, O, Erb, T.J, Shima, S, Wagner, T.
登録日2017-10-25
公開日2018-03-14
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Archaeal acetoacetyl-CoA thiolase/HMG-CoA synthase complex channels the intermediate via a fused CoA-binding site.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
7CW4
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Acetyl-CoA acetyltransferase from Bacillus cereus ATCC 14579
分子名称: Acetyl-CoA acetyltransferase, GLYCEROL
著者Hong, J, Kim, K.J.
登録日2020-08-27
公開日2020-10-07
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.56 Å)
主引用文献Crystal structure of an acetyl-CoA acetyltransferase from PHB producing bacterium Bacillus cereus ATCC 14579.
Biochem.Biophys.Res.Commun., 533, 2020
4E1L
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BU of 4e1l by Molmil
Crystal structure of Acetoacetyl-CoA thiolase (thlA2) from Clostridium difficile
分子名称: Acetoacetyl-CoA thiolase 2, IODIDE ION
著者Anderson, S.M, Wawrzak, Z, Kudritska, M, Peterson, S.N, Anderson, W.F, Savchenko, A, Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2012-03-06
公開日2012-03-21
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献

7CW5
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BU of 7cw5 by Molmil
Acetyl-CoA acetyltransferase from Bacillus cereus ATCC 14579
分子名称: Acetyl-CoA acetyltransferase, COENZYME A
著者Hong, J, Kim, K.J.
登録日2020-08-27
公開日2020-10-07
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of an acetyl-CoA acetyltransferase from PHB producing bacterium Bacillus cereus ATCC 14579.
Biochem.Biophys.Res.Commun., 533, 2020
3SS6
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BU of 3ss6 by Molmil
Crystal structure of the Bacillus anthracis acetyl-CoA acetyltransferase
分子名称: Acetyl-CoA acetyltransferase, POTASSIUM ION, SULFATE ION
著者Anderson, S.M, Wawrzak, Z, Onopriyenko, O, Peterson, S.N, Anderson, W.F, Savchenko, A, Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2011-07-07
公開日2011-07-20
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal structure of the Bacillus anthracis acetyl-CoA acetyltransferase
TO BE PUBLISHED
6L2G
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Crystal structure of Aspergillus fumigatus mitochondrial acetyl-CoA acetyltransferase
分子名称: Acetyl-CoA-acetyltransferase, putative
著者Zhang, Y, Wei, W, Raimi, O.G, Ferenbach, A.T, Fang, W.
登録日2019-10-03
公開日2020-02-12
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.41 Å)
主引用文献Aspergillus fumigatus Mitochondrial Acetyl Coenzyme A Acetyltransferase as an Antifungal Target.
Appl.Environ.Microbiol., 86, 2020
6L2C
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Crystal structure of Aspergillus fumigatus mitochondrial acetyl-CoA acetyltransferase in complex with CoA
分子名称: Acetyl-CoA-acetyltransferase, putative, COENZYME A
著者Zhang, Y, Wei, W, Raimi, O.G, Ferenbach, A.T, Fang, W.
登録日2019-10-03
公開日2020-02-12
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.44 Å)
主引用文献Aspergillus fumigatus Mitochondrial Acetyl Coenzyme A Acetyltransferase as an Antifungal Target.
Appl.Environ.Microbiol., 86, 2020
4YZO
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BU of 4yzo by Molmil
Crystal Structure Analysis of Thiolase-like protein, ST0096 from Sulfolobus Tokodaii
分子名称: ACETATE ION, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ...
著者Padmanabhan, B, Manjula, R, Yokoyama, S, Bessho, Y.
登録日2015-03-25
公開日2016-03-30
最終更新日2020-02-19
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal Structure Analysis of Thiolase-like protein, ST0096 from Sulfolobus Tokodaii
To Be Published
4DD5
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BU of 4dd5 by Molmil
Biosynthetic Thiolase (ThlA1) from Clostridium difficile
分子名称: Acetyl-CoA acetyltransferase
著者Filippova, E.V, Wawrzak, Z, Kudritska, M, Edwards, A, Savchenko, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2012-01-18
公開日2012-02-01
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.25 Å)
主引用文献Biosynthetic Thiolase (ThlA1) from Clostridium difficile
To be Published
4ZRC
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BU of 4zrc by Molmil
Crystal structure of MSM-13, a putative T1-like thiolase from Mycobacterium smegmatis
分子名称: Beta-ketothiolase
著者Janardan, N, Harijan, R.K, Keima, T.R, Wierenga, R, Murthy, M.R.N.
登録日2015-05-12
公開日2016-05-18
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural characterization of a mitochondrial 3-ketoacyl-CoA (T1)-like thiolase from Mycobacterium smegmatis
Acta Crystallogr.,Sect.D, 71, 2015

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