PDB: 716 件ウェブページステータス検索Chemie searchBIRD

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1GWZ	CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THE PROTEIN TYROSINE PHOSPHATASE SHP-1 分子名称: SHP-1 著者 Yang, J, Liang, X, Niu, T, Meng, W, Zhao, Z, Zhou, G.W. 登録日 1998-08-22 公開日 1999-08-22 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structure of the catalytic domain of protein-tyrosine phosphatase SHP-1. J.Biol.Chem., 273, 1998
4Y14	Structure of protein tyrosine phosphatase 1B complexed with inhibitor (PTP1B:CPT157633) 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3-bromo-4-[difluoro(phosphono)methyl]-N-methyl-Nalpha-(methylsulfonyl)-L-phenylalaninamide, CHLORIDE ION, ... 著者 Choy, M.S, Connors, C, Page, R, Peti, W. 登録日 2015-02-06 公開日 2015-08-05 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.898 Å) 主引用文献 PTP1B inhibition suggests a therapeutic strategy for Rett syndrome. J.Clin.Invest., 125, 2015
2A3K	Crystal Structure of the Human Protein Tyrosine Phosphatase, PTPN7 (HePTP, Hematopoietic Protein Tyrosine Phosphatase) 分子名称: PHOSPHATE ION, protein tyrosine phosphatase, non-receptor type 7, ... 著者 Barr, A, Turnbull, A.P, Das, S, Eswaran, J, Debreczeni, J.E, Longmann, E, Smee, C, Burgess, N, Gileadi, O, Sundstrom, M, Arrowsmith, C, Edwards, A, von Delft, F, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2005-06-24 公開日 2005-07-19 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 The crystal structure of human receptor protein tyrosine phosphatase kappa phosphatase domain 1. Protein Sci., 15, 2006
3S3H	Crystal structure of the catalytic domain of PTP10D from Drosophila melanogaster with a phosphopeptide substrate GP4 分子名称: 1,4-BUTANEDIOL, 1-BUTANOL, Tyrosine-protein phosphatase 10D, ... 著者 Madan, L.L, Gopal, B. 登録日 2011-05-18 公開日 2011-11-02 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Conformational basis for substrate recruitment in protein tyrosine phosphatase 10D Biochemistry, 50, 2011
2Y2F	Crystal structure of Yersinia pestis YopH in complex with an aminooxy- containing platform compound for inhibitor design 分子名称: PROTEIN-TYROSINE PHOSPHATASE YOPH, [4-[3-(DIFLUORO-PHOSPHONO-METHYL)PHENYL]PHENYL]METHOXYAZANIUM 著者 Lountos, G.T, Bahta, M, Dyas, B, Ulrich, R.G, Waugh, D.S, Burke, T.R. 登録日 2010-12-14 公開日 2011-03-16 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Utilization of Nitrophenylphosphates and Oxime-Based Ligation for the Development of Nanomolar Affinity Inhibitors of the Yersinia Pestis Outer Protein H (Yoph) Phosphatase. J.Med.Chem., 54, 2011
7S4F	Protein Tyrosine Phosphatase 1B - F182Q mutant bound with Hepes 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCEROL, MAGNESIUM ION, ... 著者 Brandao, T.A.S, Hengge, A.C, Johnson, S.J. 登録日 2021-09-08 公開日 2022-09-21 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Insights into the importance of WPD-loop sequence for activity and structure in protein tyrosine phosphatases. Chem Sci, 13, 2022
7TVJ	Crystal Structure of Monobody Mb(SHP2PTP_13)/SHP2 PTP Domain Complex 分子名称: CITRATE ANION, Mb(SHP2PTP_13), Tyrosine-protein phosphatase non-receptor type 11 著者 Sha, F, Koide, S. 登録日 2022-02-05 公開日 2023-02-15 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.39 Å) 主引用文献 Monobody Inhibitor Selective to the Phosphatase Domain of SHP2 and its Use as a Probe for Quantifying SHP2 Allosteric Regulation. J.Mol.Biol., 435, 2023
8DU7	Room-temperature serial synchrotron crystallography (SSX) structure of apo PTP1B 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Tyrosine-protein phosphatase non-receptor type 1 著者 Ebrahim, A, Sharma, S, Keedy, D.A. 登録日 2022-07-27 公開日 2022-08-17 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Room-temperature serial synchrotron crystallography of the human phosphatase PTP1B. Acta Crystallogr.,Sect.F, 79, 2023
6ZZ4	Crystal structure of the PTPN2 C216G mutant 分子名称: PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 2 著者 Mechaly, A.E, Berthelet, J, Nian, Q, Parlato, M, Cerf-Bensussan, N, Haouz, A, Rodrigues-Lima, F. 登録日 2020-08-03 公開日 2021-08-18 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.43 Å) 主引用文献 Structural characterization of a pathogenic mutant of human protein tyrosine phosphatase PTPN2 (Cys216Gly) that causes very early onset autoimmune enteropathy. Protein Sci., 31, 2022
6H8S	CRYSTAL STRUCTURE OF THE MOUSE PROTEIN TYROSINE PHOSPHATASE PTPN5 (STEP) IN COMPLEX WITH COMPOUND BI-0314 分子名称: 1-[3-piperidin-4-yl-5-(trifluoromethyl)phenyl]guanidine, Tyrosine-protein phosphatase non-receptor type 5 著者 Fiegen, D, Schnapp, G. 登録日 2018-08-03 公開日 2018-09-26 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.771 Å) 主引用文献 Allosteric Activation of Striatal-Enriched Protein Tyrosine Phosphatase (STEP, PTPN5) by a Fragment-like Molecule. J. Med. Chem., 62, 2019
3MOW	Crystal structure of SHP2 in complex with a tautomycetin analog TTN D-1 分子名称: (2Z)-2-[(1R)-3-{[(1R,2S,3R,6S,7S,10S,12S,15E,17E)-18-carboxy-16-ethyl-3,7-dihydroxy-1,2,6,10,12-pentamethyl-5-oxooctade ca-15,17-dien-1-yl]oxy}-1-hydroxy-3-oxopropyl]-3-methylbut-2-enedioic acid, Tyrosine-protein phosphatase non-receptor type 11 著者 Zhang, Z.-Y, Liu, S, Yu, Z, Yu, X. 登録日 2010-04-23 公開日 2011-05-04 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structure of SHP2 in complex with a tautomycetin analog TTN D-1 To be Published
3M4U	Crystal Structure of Trypanosoma brucei Protein Tyrosine Phosphatase TbPTP1 分子名称: PHOSPHATE ION, Tyrosine specific protein phosphatase, putative 著者 Chou, S, Alber, T, Grundner, C. 登録日 2010-03-12 公開日 2010-05-05 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.392 Å) 主引用文献 The Trypanosoma brucei life cycle switch TbPTP1 is structurally conserved and dephosphorylates the nucleolar protein NOPP44/46. J.Biol.Chem., 285, 2010
6H8R	CRYSTAL STRUCTURE OF THE HUMAN PROTEIN TYROSINE PHOSPHATASE PTPN5 (STEP) IN COMPLEX WITH COMPOUND 2 分子名称: 3-[(2~{S})-2-azanylpropyl]-5-(trifluoromethyl)phenol, SULFATE ION, Tyrosine-protein phosphatase non-receptor type 5 著者 Hoerer, S, Fiegen, D, Schnapp, G. 登録日 2018-08-03 公開日 2018-09-26 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.66 Å) 主引用文献 Allosteric Activation of Striatal-Enriched Protein Tyrosine Phosphatase (STEP, PTPN5) by a Fragment-like Molecule. J. Med. Chem., 62, 2019
6PFW	Protein Tyrosine Phosphatase 1B (1-301), T177A mutant, apo state 分子名称: ACETATE ION, GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1 著者 Cui, D.S, Lipchock, J.M, Loria, J.P. 登録日 2019-06-22 公開日 2019-08-07 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.34 Å) 主引用文献 Uncovering the Molecular Interactions in the Catalytic Loop That Modulate the Conformational Dynamics in Protein Tyrosine Phosphatase 1B. J.Am.Chem.Soc., 141, 2019
6PG0	Protein Tyrosine Phosphatase 1B (1-301), P188A mutant, vanadate bound state 分子名称: GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1, VANADATE ION 著者 Cui, D.S, Lipchock, J.M, Loria, J.P. 登録日 2019-06-23 公開日 2019-08-07 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Uncovering the Molecular Interactions in the Catalytic Loop That Modulate the Conformational Dynamics in Protein Tyrosine Phosphatase 1B. J.Am.Chem.Soc., 141, 2019
6PM8	Protein Tyrosine Phosphatase 1B (1-301), P180A mutant, vanadate bound state 分子名称: GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1, VANADATE ION 著者 Cui, D.S, Lipchock, J.M, Loria, J.P. 登録日 2019-07-01 公開日 2019-08-07 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.06 Å) 主引用文献 Uncovering the Molecular Interactions in the Catalytic Loop That Modulate the Conformational Dynamics in Protein Tyrosine Phosphatase 1B. J.Am.Chem.Soc., 141, 2019
6PGT	Protein Tyrosine Phosphatase 1B (1-301), T177A mutant, vanadate bound state 分子名称: GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1, VANADATE ION 著者 Cui, D.S, Lipchock, J.M, Loria, J.P. 登録日 2019-06-24 公開日 2019-08-07 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Uncovering the Molecular Interactions in the Catalytic Loop That Modulate the Conformational Dynamics in Protein Tyrosine Phosphatase 1B. J.Am.Chem.Soc., 141, 2019
6PHA	Protein Tyrosine Phosphatase 1B (1-301), F182A mutant, vanadate bound state 分子名称: ACETATE ION, GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1, ... 著者 Cui, D.S, Lipchock, J.M, Loria, J.P. 登録日 2019-06-25 公開日 2019-08-07 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.299 Å) 主引用文献 Uncovering the Molecular Interactions in the Catalytic Loop That Modulate the Conformational Dynamics in Protein Tyrosine Phosphatase 1B. J.Am.Chem.Soc., 141, 2019
6PHS	Protein Tyrosine Phosphatase 1B (1-301), P185A mutant, vanadate bound state 分子名称: GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1, VANADATE ION 著者 Cui, D.S, Lipchock, J.M, Loria, J.P. 登録日 2019-06-25 公開日 2019-08-07 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.129 Å) 主引用文献 Uncovering the Molecular Interactions in the Catalytic Loop That Modulate the Conformational Dynamics in Protein Tyrosine Phosphatase 1B. J.Am.Chem.Soc., 141, 2019
5OVR	X-Ray Characterization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors 分子名称: Tyrosine-protein phosphatase non-receptor type 5, [(~{S})-[4-[3-[(~{R})-(3,4-dichlorophenyl)-oxidanyl-methyl]phenyl]phenyl]-oxidanyl-methyl]phosphonic acid 著者 Kack, H, Wissler, L. 登録日 2017-08-29 公開日 2017-11-22 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 X-ray Characterization and Structure-Based Optimization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors. J. Med. Chem., 60, 2017
5OVX	X-Ray Characterization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors 分子名称: Tyrosine-protein phosphatase non-receptor type 5, [(~{S})-[4-[3-[(~{S})-(3,4-dichlorophenyl)-oxidanyl-methyl]phenyl]phenyl]-oxidanyl-methyl]phosphonic acid 著者 Kack, H, Wissler, L. 登録日 2017-08-30 公開日 2017-11-22 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 X-ray Characterization and Structure-Based Optimization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors. J. Med. Chem., 60, 2017
5OW1	X-Ray Characterization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors 分子名称: Tyrosine-protein phosphatase non-receptor type 5, [[3-(3-cyclohexyl-2-oxidanyl-phenyl)phenyl]-bis(fluoranyl)methyl]phosphonic acid 著者 Kack, H, Wissler, L. 登録日 2017-08-30 公開日 2017-11-22 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 X-ray Characterization and Structure-Based Optimization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors. J. Med. Chem., 60, 2017
3H2X	Crystal Structure of The Human Lymphoid Tyrosine Phosphatase Catalytic Domain 分子名称: PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 22 著者 Tsai, S.J, Sen, U. 登録日 2009-04-14 公開日 2009-06-02 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal structure of the human lymphoid tyrosine phosphatase catalytic domain: insights into redox regulation . Biochemistry, 48, 2009
7XC0	Crystal structure of Human RPTPH 分子名称: PHOSPHATE ION, Receptor-type tyrosine-protein phosphatase H 著者 Kim, M, Ryu, S.E. 登録日 2022-03-22 公開日 2022-07-06 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.56 Å) 主引用文献 Crystal structure of the catalytic domain of human RPTPH. Acta Crystallogr.,Sect.F, 78, 2022
3I7Z	Protein Tyrosine Phosphatase 1B - Transition state analog for the first catalytic step 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, EGFR receptor fragment, GLYCEROL, ... 著者 Brandao, T.A.S, Johnson, S.J, Hengge, A.C. 登録日 2009-07-09 公開日 2010-03-16 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Insights into the reaction of protein-tyrosine phosphatase 1B: crystal structures for transition state analogs of both catalytic steps. J.Biol.Chem., 285, 2010

 

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