PDB: 228 件ウェブページステータス検索Chemie searchBIRD

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6I7D	Plasmodium falciparum Myosin A, post-rigor and rigor-like states 分子名称: 1,2-ETHANEDIOL, GLYCEROL, Myosin-A 著者 Robert-Paganin, J, Auguin, D, Moussaoui, D, Jousset, G, Baum, J, Trybus, K.M, Houdusse, A. 登録日 2018-11-16 公開日 2019-08-07 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.82 Å) 主引用文献 Plasmodium myosin A drives parasite invasion by an atypical force generating mechanism. Nat Commun, 10, 2019
6I7E	Plasmodium falciparum Myosin A, Pre-powerstroke 分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Myosin-A, ... 著者 Robert-Paganin, J, Auguin, D, Moussaoui, D, Jousset, G, Baum, J, Trybus, K.M, Houdusse, A. 登録日 2018-11-16 公開日 2019-08-07 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (3.492 Å) 主引用文献 Plasmodium myosin A drives parasite invasion by an atypical force generating mechanism. Nat Commun, 10, 2019
4ZG4	Myosin Vc Pre-powerstroke 分子名称: 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Ropars, V, Pylypenko, O, Sweeney, L, Houdusse, A. 登録日 2015-04-22 公開日 2016-03-23 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.36 Å) 主引用文献 Force-producing ADP state of myosin bound to actin. Proc.Natl.Acad.Sci.USA, 113, 2016
5O2L	Myosin VI motor domain in the Pre-Transition State 分子名称: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, GLYCEROL, ... 著者 Isabet, T, Benisty, H, Houdusse, A. 登録日 2017-05-22 公開日 2018-05-23 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 An intermediate along the recovery stroke of myosin VI revealed by X-ray crystallography and molecular dynamics. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
4E7Z	Myosin VI (MD) pre-powerstroke state, P21 crystal form 分子名称: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... 著者 Isabet, T, Sweeney, H.L, Houdusse, A. 登録日 2012-03-19 公開日 2012-09-19 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Processive Steps in the Reverse Direction Require Uncoupling of the Lead Head Lever Arm of Myosin VI. Mol.Cell, 48, 2012
4E7S	Myosin VI D23R I24R R569E (MD) pre-powerstroke state 分子名称: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... 著者 Isabet, T, Sweeney, H.L, Houdusse, A. 登録日 2012-03-19 公開日 2012-09-19 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Processive Steps in the Reverse Direction Require Uncoupling of the Lead Head Lever Arm of Myosin VI. Mol.Cell, 48, 2012
4DBR	Myosin VI D179Y (MD) pre-powerstroke state 分子名称: 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Pylypenko, O, Sweeney, H.L, Houdusse, A. 登録日 2012-01-16 公開日 2013-01-30 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Mutations in myosin VI that cause a loss of coordination between heads provide insights into the structural changes underlying force generation and the importance of gating To be Published
5HMP	Myosin Vc pre-powerstroke state 分子名称: 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, DIMETHYL SULFOXIDE, ... 著者 Ropars, V, Pylypenko, O, Sweeney, H.L, Houdusse, A. 登録日 2016-01-16 公開日 2016-09-07 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.397 Å) 主引用文献 The myosin X motor is optimized for movement on actin bundles. Nat Commun, 7, 2016
6DUE	Toxoplasma gondii MyoA, a Class-XIV myosin, in the pre-powerstroke state 分子名称: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... 著者 Powell, C.J, Boulanger, M.J. 登録日 2018-06-20 公開日 2018-10-31 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural and mechanistic insights into the function of the unconventional class XIV myosin MyoA fromToxoplasma gondii. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
1W8J	Crystal Structure Of Myosin V Motor Domain - Nucleotide-Free 分子名称: MYOSIN VA, SULFATE ION 著者 Coureux, P.-D, Sweeney, H.L, Houdusse, A. 登録日 2004-09-22 公開日 2005-02-22 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Three Myosin V Structures Delineate Essential Features of Chemo-Mechanical Transduction Embo J., 23, 2004
1LKX	MOTOR DOMAIN OF MYOE, A CLASS-I MYOSIN 分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, MYOSIN IE HEAVY CHAIN, ... 著者 Kollmar, M, Durrwang, U, Kliche, W, Manstein, D.J, Kull, F.J. 登録日 2002-04-26 公開日 2002-06-26 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Crystal structure of the motor domain of a class-I myosin. EMBO J., 21, 2002
2V26	Myosin VI (MD) pre-powerstroke state (Mg.ADP.VO4) 分子名称: 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Menetrey, J, Llinas, P, Mukherjea, M, Sweeney, H.L, Houdusse, A. 登録日 2007-06-03 公開日 2007-11-20 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 The Structural Basis for the Large Powerstroke of Myosin Vi. Cell(Cambridge,Mass.), 131, 2007
4PK4	Myosin VI motor domain in the PPS state - from a Pi release state crystal, space group P212121 after long soaking with PO4 分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ... 著者 Isabet, T, Benisty, H, Llinas, P, Sweeney, H.L, Houdusse, A. 登録日 2014-05-13 公開日 2015-04-29 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.78 Å) 主引用文献 How actin initiates the motor activity of Myosin. Dev.Cell, 33, 2015
4PFO	Myosin VI motor domain in the Pi release state, space group P212121 分子名称: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... 著者 Isabet, T, Benisty, H, Llinas, P, Sweeney, H.L, Houdusse, A. 登録日 2014-04-30 公開日 2015-04-29 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 How actin initiates the motor activity of Myosin. Dev.Cell, 33, 2015
4PJM	Myosin VI motor domain in the Pi release state, space group P212121 - soaked with PO4 - located in the active site 分子名称: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, ISOPROPYL ALCOHOL, ... 著者 Isabet, T, Benisty, H, Llinas, P, Sweeney, H.L, Houdusse, A. 登録日 2014-05-12 公開日 2015-04-29 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 How actin initiates the motor activity of Myosin. Dev.Cell, 33, 2015
4PFP	Myosin VI motor domain in the Pi release state (with Pi) space group P21 分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ... 著者 Isabet, T, Benisty, H, Llinas, P, Sweeney, H.L, Houdusse, A. 登録日 2014-04-30 公開日 2015-04-29 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.32 Å) 主引用文献 How actin initiates the motor activity of Myosin. Dev.Cell, 33, 2015
4PJN	Myosin VI motor domain in the Pi release state, space group P212121 - shortly soaked with PO4 分子名称: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... 著者 Isabet, T, Benisty, H, Llinas, P, Sweeney, H.L, Houdusse, A. 登録日 2014-05-12 公開日 2015-04-29 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 How actin initiates the motor activity of Myosin. Dev.Cell, 33, 2015
4PJL	Myosin VI motor domain A458E mutant in the Pi release state, space group P212121 - 分子名称: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... 著者 Isabet, T, Benisty, H, Llinas, P, Sweeney, H.L, Houdusse, A. 登録日 2014-05-12 公開日 2015-04-29 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 How actin initiates the motor activity of Myosin. Dev.Cell, 33, 2015
9F6C	Cardiac myosin motor domain in the pre-powerstroke state co-crystallized with the inhibitor aficamten 分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Myosin-7, ... 著者 Robert-Paganin, J, Hartman, J.J, Morgan, B.P, Malik, F.I, Houdusse, A. 登録日 2024-05-01 公開日 2024-09-04 最終更新日 2024-09-11 実験手法 X-RAY DIFFRACTION (2.33 Å) 主引用文献 Aficamten is a small-molecule cardiac myosin inhibitor designed to treat hypertrophic cardiomyopathy. Nat Cardiovasc Res, 3, 2024
8CDQ	Plasmodium falciparum Myosin A full-length, post-rigor state complexed to the inhibitor KNX-002 and Mg.ATP-gamma-S 分子名称: 1,2-ETHANEDIOL, 1-(4-methoxyphenyl)-~{N}-[(3-thiophen-2-yl-1~{H}-pyrazol-4-yl)methyl]cyclopropan-1-amine, GLYCEROL, ... 著者 Moussaoui, D, Robblee, J.P, Robert-Paganin, J, Auguin, D, Fisher, F, Fagnant, P.M, MacFarlane, J.E, Schaletzky, J, Wehri, E, Mueller-Dieckmann, C, Baum, J, Trybus, K.M, Houdusse, A. 登録日 2023-01-31 公開日 2023-06-21 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.21 Å) 主引用文献 Mechanism of small molecule inhibition of Plasmodium falciparum myosin A informs antimalarial drug design. Nat Commun, 14, 2023
8W41	Cryo-EM structure of Myosin VI in the autoinhibited state 分子名称: ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, Calmodulin-1, ... 著者 Niu, F, Wei, Z. 登録日 2023-08-23 公開日 2024-02-21 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (3.54 Å) 主引用文献 Autoinhibition and activation of myosin VI revealed by its cryo-EM structure. Nat Commun, 15, 2024
8CDM	Plasmodium falciparum Myosin A full-length, post-rigor state complexed to the inhibitor KNX-002 分子名称: 1,2-ETHANEDIOL, 1-(4-methoxyphenyl)-~{N}-[(3-thiophen-2-yl-1~{H}-pyrazol-4-yl)methyl]cyclopropan-1-amine, Myosin A tail domain interacting protein, ... 著者 Moussaoui, D, Robblee, J.P, Robert-Paganin, J, Auguin, D, Fisher, F, Fagnant, P.M, MacFarlane, J.E, Mueller-Dieckmann, C, Baum, J, Trybus, K.M, Houdusse, A. 登録日 2023-01-31 公開日 2024-02-21 最終更新日 2024-09-04 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Mechanism of small molecule inhibition of Plasmodium falciparum myosin A informs antimalarial drug design. Nat Commun, 14, 2023
6QDJ	Molecular features of the UNC-45 chaperone critical for binding and folding muscle myosin 分子名称: 1,4-BUTANEDIOL, 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL, ADENOSINE-5'-DIPHOSPHATE, ... 著者 Meinhart, A, Clausen, T, Arnese, R. 登録日 2019-01-02 公開日 2019-10-30 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.884 Å) 主引用文献 Molecular features of the UNC-45 chaperone critical for binding and folding muscle myosin. Nat Commun, 10, 2019
6FSA	Beta-Cardiac myosin post-rigor 分子名称: 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, FORMIC ACID, ... 著者 Robert-Paganin, J, Auguin, D, Houdusse, A. 登録日 2018-02-19 公開日 2018-07-25 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.33 Å) 主引用文献 Hypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibition. Nat Commun, 9, 2018
7DHW	Crystal structure of myosin-XI motor domain in complex with ADP-ALF4 分子名称: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... 著者 Suzuki, K, Haraguchi, T, Tamanaha, M, Yoshimura, K, Imi, T, Tominaga, M, Sakayama, H, Nishiyama, T, Ito, K, Murata, T. 登録日 2020-11-17 公開日 2021-05-19 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.84 Å) 主引用文献 Discovery of ultrafast myosin, its amino acid sequence, and structural features. Proc.Natl.Acad.Sci.USA, 119, 2022

 

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