PDB: 278 件ウェブページステータス検索Chemie searchBIRD

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5GJJ	Glutathionylated hHsp70 SBD 分子名称: Heat shock 70 kDa protein 1A 著者 Gong, W.B, Yang, J, Zhang, H, Perrett, S. 登録日 2016-06-30 公開日 2017-07-05 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Structure of glutathionylated hHsp70 SBD (385-641) To Be Published
2KHO	NMR-RDC / XRAY structure of E. coli HSP70 (DNAK) chaperone (1-605) complexed with ADP and substrate 分子名称: Heat shock protein 70 著者 Zuiderweg, E.R.P, Bertelsen, E.B. 登録日 2009-04-10 公開日 2009-05-12 最終更新日 2021-08-18 実験手法 SOLUTION NMR 主引用文献 Solution conformation of wild-type E. coli Hsp70 (DnaK) chaperone complexed with ADP and substrate. Proc.Natl.Acad.Sci.USA, 106, 2009
6HAB	Crystal structure of BiP V461F (apo) 分子名称: DI(HYDROXYETHYL)ETHER, Endoplasmic reticulum chaperone BiP 著者 Yan, Y, Ron, D. 登録日 2018-08-07 公開日 2019-02-06 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.08 Å) 主引用文献 MANF antagonizes nucleotide exchange by the endoplasmic reticulum chaperone BiP. Nat Commun, 10, 2019
2V7Z	Crystal structure of the 70-kDa heat shock cognate protein from Rattus norvegicus in post-ATP hydrolysis state 分子名称: ADENOSINE-5'-DIPHOSPHATE, HEAT SHOCK COGNATE 71 KDA PROTEIN, PHOSPHATE ION 著者 Chang, Y.-W, Sun, Y.-J, Wang, C, Hsiao, C.-D. 登録日 2007-08-02 公開日 2008-04-08 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Crystal Structures of the 70-kDa Heat Shock Proteins in Domain Disjoining Conformation. J.Biol.Chem., 283, 2008
2V7Y	Crystal structure of the molecular chaperone DnaK from Geobacillus kaustophilus HTA426 in post-ATP hydrolysis state 分子名称: ADENOSINE-5'-DIPHOSPHATE, CHAPERONE PROTEIN DNAK, MAGNESIUM ION, ... 著者 Chang, Y.-W, Sun, Y.-J, Wang, C, Hsiao, C.-D. 登録日 2007-08-02 公開日 2008-04-08 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.37 Å) 主引用文献 Crystal Structures of the 70-kDa Heat Shock Proteins in Domain Disjoining Conformation. J.Biol.Chem., 283, 2008
5TKY	Crystal structure of the co-translational Hsp70 chaperone Ssb in the ATP-bound, open conformation 分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Putative uncharacterized protein 著者 Gumiero, A, Gese, G.V, Weyer, F.A, Lapouge, K, Sinning, I. 登録日 2016-10-10 公開日 2016-11-16 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Interaction of the cotranslational Hsp70 Ssb with ribosomal proteins and rRNA depends on its lid domain. Nat Commun, 7, 2016
1U00	HscA substrate binding domain complexed with the IscU recognition peptide ELPPVKIHC 分子名称: Chaperone protein hscA, IscU recognition peptide 著者 Cupp-Vickery, J.R, Peterson, J.C, Ta, D.T, Vickery, L.E. 登録日 2004-07-12 公開日 2004-10-05 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Crystal Structure of the Molecular Chaperone HscA Substrate Binding Domain Complexed with the IscU Recognition Peptide ELPPVKIHC. J.Mol.Biol., 342, 2004
5UMB	Crystal structure of ATPase domain of Malaria GRP78 with ADP bound 分子名称: ADENOSINE-5'-DIPHOSPHATE, Chaperone DnaK, MAGNESIUM ION, ... 著者 Chen, Y, Antoshchenko, T, Pizarro, J.C, Song, J.H, Park, H. 登録日 2017-01-26 公開日 2022-07-27 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Repurposing drugs to target the malaria parasite unfolding protein response. Sci Rep, 8, 2018
6NHK	Mortalin nucleotide binding domain in the ADP-bound state 分子名称: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... 著者 Page, R.C, Moseng, M.A, Nix, J.C. 登録日 2018-12-23 公開日 2019-04-17 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.777 Å) 主引用文献 Biophysical Consequences of EVEN-PLUS Syndrome Mutations for the Function of Mortalin. J.Phys.Chem.B, 123, 2019
7PLK	Crystal structure bovine Hsc70(aa1-554)E213A/D214A in complex with nicotinic-acid-derivative 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5-pyrrol-1-ylpyridine-3-carboxylic acid, GLYCEROL, ... 著者 Zehe, M, Grimm, C, Sotriffer, C. 登録日 2021-08-31 公開日 2022-09-07 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.48781371 Å) 主引用文献 Combined In-Solution Fragment Screening and Crystallographic Binding-Mode Analysis with a Two-Domain Hsp70 Construct. Acs Chem.Biol., 2024
7Q4R	Crystal structure of human HSP72-NBD in complex with fragment 1 分子名称: 4-(4-phenyl-1,3-thiazol-2-yl)piperazine-1-carboxamide, Heat shock 70 kDa protein 1A, MAGNESIUM ION, ... 著者 Le Bihan, Y.V, Westwood, I.M, van Montfort, R.L.M. 登録日 2021-11-02 公開日 2022-02-02 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 Discovery and Characterization of a Cryptic Secondary Binding Site in the Molecular Chaperone HSP70. Molecules, 27, 2022
6S02	Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain - ADP bound state 分子名称: ADENOSINE-5'-DIPHOSPHATE, Heat shock protein 70, MAGNESIUM ION 著者 Vakonakis, I, Day, J. 登録日 2019-06-13 公開日 2019-10-02 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 ThePlasmodium falciparumHsp70-x chaperone assists the heat stress response of the malaria parasite. Faseb J., 33, 2019
6RZQ	Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain - ANP-PnP bound state 分子名称: GLYCEROL, Heat shock protein 70, MAGNESIUM ION, ... 著者 Vakonakis, I, Day, J. 登録日 2019-06-13 公開日 2019-10-02 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.81 Å) 主引用文献 ThePlasmodium falciparumHsp70-x chaperone assists the heat stress response of the malaria parasite. Faseb J., 33, 2019
6P2U	Structure of Mortalin-NBD with N6-propargyladenosine-5'-diphosphate 分子名称: 9-{5-O-[(S)-hydroxy(phosphonooxy)phosphoryl]-alpha-D-ribofuranosyl}-N-(prop-2-yn-1-yl)-9H-purin-6-amine, MAGNESIUM ION, PHOSPHATE ION, ... 著者 Moseng, M.A, Page, R.C. 登録日 2019-05-22 公開日 2019-06-19 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 2- and N6-functionalized adenosine-5'-diphosphate analogs for the inhibition of mortalin. Febs Lett., 593, 2019
4B9Q	Open conformation of ATP-bound Hsp70 homolog DnaK 分子名称: ADENOSINE-5'-TRIPHOSPHATE, CHAPERONE PROTEIN DNAK, MAGNESIUM ION 著者 Kopp, J, Mayer, M.P, Sinning, I. 登録日 2012-09-06 公開日 2012-11-14 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structure and Dynamics of the ATP-Bound Open Conformation of Hsp70 Chaperones Mol.Cell, 48, 2012
7RAX	ATP-binding state of the nucleotide-binding domain of Hsp70 DnaK mutant T199A 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Chaperone protein DnaK, GLYCEROL, ... 著者 Wang, W, Hendrickson, W.A. 登録日 2021-07-04 公開日 2023-07-05 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.41 Å) 主引用文献 Visualization of Hsp70-catalyzed ATP Hydrolysis To Be Published
6PMT	Structure of Mortalin-NBD with adenosine-5'-monophosphate and thiodiphosphate 分子名称: ADENOSINE MONOPHOSPHATE, PHOSPHATE ION, Stress-70 protein, ... 著者 Moseng, M.A, Nix, J.C, Page, R.C. 登録日 2019-07-02 公開日 2020-07-08 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structure of the mortalin nucleotide binding domain in complex with adenosine monophosphate to be published
6SR6	Crystal structure of the RAC core with a pseudo substrate bound to Ssz1 SBD 分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Putative heat shock protein, ... 著者 Valentin Gese, G, Lapouge, K, Kopp, J, Sinning, I. 登録日 2019-09-05 公開日 2020-03-25 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 The ribosome-associated complex RAC serves in a relay that directs nascent chains to Ssb. Nat Commun, 11, 2020
5MKR	HSP72-NBD bound to compound TCI 8 - Tyr15 in up-conformation 分子名称: 3-[(2~{R},3~{S},4~{R},5~{R})-5-[6-azanyl-8-[(4-chlorophenyl)methylamino]purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]propyl prop-2-enoate, CITRATE ANION, Heat shock 70 kDa protein 1A 著者 Pettinger, J, Westwood, I.M, Cronin, N, Le Bihan, Y.-V, Van Montfort, R.L.M. 登録日 2016-12-05 公開日 2017-03-01 最終更新日 2017-03-29 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 An Irreversible Inhibitor of HSP72 that Unexpectedly Targets Lysine-56. Angew. Chem. Int. Ed. Engl., 56, 2017
5MB9	Crystal structure of the eukaryotic ribosome associated complex (RAC), a unique Hsp70/Hsp40 pair 分子名称: ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... 著者 Gumiero, A, Weyer, F.A, Valentin Gese, G, Lapouge, K, Sinning, I. 登録日 2016-11-07 公開日 2016-12-28 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Structural insights into a unique Hsp70-Hsp40 interaction in the eukaryotic ribosome-associated complex. Nat. Struct. Mol. Biol., 24, 2017
5MKS	HSP72-NBD bound to compound TCI 8 - Tyr15 in down-conformation 分子名称: 3-[(2~{R},3~{S},4~{R},5~{R})-5-[6-azanyl-8-[(4-chlorophenyl)methylamino]purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]propyl prop-2-enoate, Heat shock 70 kDa protein 1A 著者 Pettinger, J, Westwood, I.M, Cronin, N, Le Bihan, Y.-V, Van Montfort, R.L.M. 登録日 2016-12-05 公開日 2017-03-01 最終更新日 2017-03-29 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 An Irreversible Inhibitor of HSP72 that Unexpectedly Targets Lysine-56. Angew. Chem. Int. Ed. Engl., 56, 2017
1BPR	NMR STRUCTURE OF THE SUBSTRATE BINDING DOMAIN OF DNAK, MINIMIZED AVERAGE STRUCTURE 分子名称: DNAK 著者 Wang, H, Kurochkin, A.V, Pang, Y, Hu, W, Flynn, G.C, Zuiderweg, E.R.P. 登録日 1998-08-11 公開日 1999-03-02 最終更新日 2022-02-16 実験手法 SOLUTION NMR 主引用文献 NMR solution structure of the 21 kDa chaperone protein DnaK substrate binding domain: a preview of chaperone-protein interaction. Biochemistry, 37, 1998
1ATS	THREONINE 204 OF THE CHAPERONE PROTEIN HSC70 INFLUENCES THE STRUCTURE OF THE ACTIVE SITE BUT IS NOT ESSENTIAL FOR ATP HYDROLYSIS 分子名称: ADENOSINE-5'-DIPHOSPHATE, HEAT-SHOCK COGNATE 70 KD PROTEIN, MAGNESIUM ION 著者 O'Brien, M.C, Mckay, D.B. 登録日 1993-08-09 公開日 1993-10-31 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.43 Å) 主引用文献 Threonine 204 of the chaperone protein Hsc70 influences the structure of the active site, but is not essential for ATP hydrolysis. J.Biol.Chem., 268, 1993
1BA0	HEAT-SHOCK COGNATE 70KD PROTEIN 44KD ATPASE N-TERMINAL 1NGE 3 分子名称: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, HEAT-SHOCK COGNATE 70KD PROTEIN, ... 著者 Wilbanks, S.M, Mckay, D.B. 登録日 1998-04-21 公開日 1998-07-15 最終更新日 2023-08-02 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural replacement of active site monovalent cations by the epsilon-amino group of lysine in the ATPase fragment of bovine Hsc70. Biochemistry, 37, 1998
1BA1	HEAT-SHOCK COGNATE 70KD PROTEIN 44KD ATPASE N-TERMINAL MUTANT WITH CYS 17 REPLACED BY LYS 分子名称: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, HEAT-SHOCK COGNATE 70KD PROTEIN, ... 著者 Wilbanks, S.M, Mckay, D.B. 登録日 1998-04-21 公開日 1998-07-15 最終更新日 2023-08-02 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural replacement of active site monovalent cations by the epsilon-amino group of lysine in the ATPase fragment of bovine Hsc70. Biochemistry, 37, 1998

 

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