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9ILB	HUMAN INTERLEUKIN-1 BETA Descriptor: PROTEIN (HUMAN INTERLEUKIN-1 BETA) Authors: Yu, B, Blaber, M, Gronenborn, A.M, Clore, G.M, Caspar, D.L.D. Deposit date: 1998-10-22 Release date: 1999-01-06 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.28 Å) Cite: Disordered water within a hydrophobic protein cavity visualized by x-ray crystallography. Proc.Natl.Acad.Sci.USA, 96, 1999
4EEE	Crystal Structure of YLDV 14L IL-18 Binding Protein in Complex with Human IL-18 Descriptor: 14L protein, Interleukin-18 Authors: Krumm, B.E, Xiang, Y, Deng, J. Deposit date: 2012-03-28 Release date: 2012-09-26 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.71 Å) Cite: A unique bivalent binding and inhibition mechanism by the yatapoxvirus interleukin 18 binding protein. Plos Pathog., 8, 2012
4R6U	IL-18 receptor complex Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-18, Interleukin-18 receptor 1 Authors: Wei, H, Wang, X. Deposit date: 2014-08-26 Release date: 2014-10-15 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structural basis for the specific recognition of IL-18 by its alpha receptor. Febs Lett., 588, 2014
6NCU	Interleukin-37 residues 53-206- dimer Descriptor: Interleukin-37 Authors: Eisenmesser, E.Z. Deposit date: 2018-12-12 Release date: 2019-03-13 Last modified: 2024-04-24 Method: X-RAY DIFFRACTION (3.5 Å) Cite: Interleukin-37 monomer is the active form for reducing innate immunity. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
3POK	Interleukin-1-beta LBT L3 Mutant Descriptor: Interleukin-1 beta Authors: Barthelmes, K, Reynolds, A.M, Peisach, E, Jonker, H.R.A, DeNunzio, N.J, Allen, K.N, Imperiali, B, Schwalbe, H. Deposit date: 2010-11-22 Release date: 2011-01-19 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Engineering encodable lanthanide-binding tags into loop regions of proteins. J.Am.Chem.Soc., 133, 2011
1MD6	High resolution crystal structure of murine IL-1F5 reveals unique loop conformation for specificity Descriptor: interleukin 1 family, member 5 (delta) Authors: Pei, X.Y, Dunn, E.F, Gay, N.J, O'Neill, L.A. Deposit date: 2002-08-07 Release date: 2003-09-30 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.6 Å) Cite: High-Resolution Structure of Murine Interleukin 1 Homologue IL-1F5 Reveals Unique Loop Conformations for Receptor Binding Specificity. Biochemistry, 42, 2003
8C3U	Crystal Structure of human IL-1beta in complex with a low molecular weight antagonist Descriptor: (S)-4'-hydroxy-3'-(6-methyl-2-oxo-3-(1H-pyrazol-4-yl)indolin-3-yl)-[1,1'-biphenyl]-2,4-dicarboxylic acid, Interleukin-1 beta Authors: Rondeau, J.-M, Lehmann, S, Koch, E. Deposit date: 2022-12-28 Release date: 2023-09-13 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (1.945 Å) Cite: Discovery of a selective and biologically active low-molecular weight antagonist of human interleukin-1 beta. Nat Commun, 14, 2023
7Z4T	AAL160 FAB IN COMPLEX WITH HUMAN INTERLEUKIN-1 BETA Descriptor: AAL160 Fab heavy-chain, AAL160 light-chain, Interleukin-1 beta Authors: Rondeau, J.M, Lehmann, S. Deposit date: 2022-03-04 Release date: 2023-02-08 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (3.3 Å) Cite: "Redirecting an anti-IL-1 beta antibody to bind a new, unrelated and computationally predicted epitope on hIL-17A". Commun Biol, 6, 2023
21BI	INTERLEUKIN-1 BETA (IL-1 BETA) (MUTANT WITH CYS 71 REPLACED BY ALA) (C71A) Descriptor: INTERLEUKIN-1 BETA Authors: Veerapandian, B, Poulos, T.L, Gilliland, G.L, Masui, Y, Hirai, Y. Deposit date: 1991-03-21 Release date: 1992-04-15 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2 Å) Cite:
6P9E	Crystal structure of IL-36gamma complexed to A-552 Descriptor: (2S)-2-{[4-(3-amino-4-methylphenyl)-6-methylpyrimidin-2-yl]oxy}-3-methoxy-3,3-diphenylpropanoic acid, Interleukin-36 gamma Authors: Argiriadi, M.A, Todorovic, T, Su, Z, Putman, B, Kakavas, S.J, Salte, K.M, McDonald, H.A, Wetter, J.B, Paulsboe, S.E, Sun, Q, Gerstein, C.E, Medina, L, Sielaff, B, Sadhukhan, R, Stockmann, H, Richardson, P.L, Qiu, W, Henry, R.F, Herold, J.M, Shotwell, J.B, McGaraughty, S.P, Honore, P, Gopalakrishnan, S.M, Sun, C.C, Scott, V.E. Deposit date: 2019-06-10 Release date: 2019-06-26 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2 Å) Cite: Small Molecule IL-36 gamma Antagonist as a Novel Therapeutic Approach for Plaque Psoriasis. Sci Rep, 9, 2019
7I1B	HIGH-RESOLUTION THREE-DIMENSIONAL STRUCTURE OF INTERLEUKIN-1 BETA IN SOLUTION BY THREE-AND FOUR-DIMENSIONAL NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY Descriptor: INTERLEUKIN-1 BETA Authors: Clore, G.M, Gronenborn, A.M. Deposit date: 1991-01-22 Release date: 1992-10-15 Last modified: 2022-03-23 Method: SOLUTION NMR Cite: High-resolution three-dimensional structure of interleukin 1 beta in solution by three- and four-dimensional nuclear magnetic resonance spectroscopy. Biochemistry, 30, 1991
2VXT	Crystal structure of human IL-18 complexed to murine reference antibody 125-2H Fab Descriptor: CHLORIDE ION, INTERLEUKIN-18, MAGNESIUM ION, ... Authors: Argiriadi, M.A, Xiang, T, Wu, C, Ghayur, T, Borhani, D.W. Deposit date: 2008-07-10 Release date: 2009-06-23 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.49 Å) Cite: Unusual Water-Mediated Antigenic Recognition of the Proinflammatory Cytokine Interleukin-18. J.Biol.Chem., 284, 2009
5MVZ	Fab 4AB007 bound to Interleukin-1-beta Descriptor: Fab 4AB007 H-chain, Fab 4AB007 L-chain, GLYCEROL, ... Authors: Stark, W, Seibert, V. Deposit date: 2017-01-17 Release date: 2017-02-15 Last modified: 2019-02-20 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Structure of a novel, fully Human Fab binding to Interleukin 1-beta. To Be Published
4IZE	Crystal Structure of IL-36gamma Descriptor: Interleukin-36 gamma Authors: Guenther, S, Sundberg, E.J. Deposit date: 2013-01-29 Release date: 2014-06-25 Last modified: 2014-07-16 Method: X-RAY DIFFRACTION (2 Å) Cite: Molecular Determinants of Agonist and Antagonist Signaling through the IL-36 Receptor. J.Immunol., 193, 2014
6HPI	NMR structure of the pro-inflammatory cytokine interleukin-36alpha Descriptor: Interleukin-36 alpha Authors: Ohlenschlaeger, O, Imhof, D. Deposit date: 2018-09-21 Release date: 2019-10-02 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: (1)H, (13)C, and (15)N resonance assignments for the pro-inflammatory cytokine interleukin-36alpha. Biomol NMR Assign, 10, 2016
7CHY	Crystal Structure Of Human Il-1beta In Complex With Antibody Binding Fragment Of IgG26 Descriptor: Interleukin-1 beta, heavy chain of antibody binding fragment of IgG26, light chain of antibody binding fragment of IgG26 Authors: Lee, C.C, Wang, A.H.J, Kuo, W.C. Deposit date: 2020-07-06 Release date: 2021-01-13 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Structure-based Development of Human Interleukin-1 beta-Specific Antibody That Simultaneously Inhibits Binding to Both IL-1RI and IL-1RAcP. J.Mol.Biol., 433, 2020
7CHZ	Crystal Structure Of Human Il-1beta In Complex With Antibody Binding Fragment Of IgG26A Descriptor: Interleukin-1 beta, heavy chain of antibody binding fragment of IgG26A, light chain of antibody binding fragment of IgG26A Authors: Lee, C.C, Wang, A.H.J, Kuo, W.C. Deposit date: 2020-07-06 Release date: 2021-01-13 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structure-based Development of Human Interleukin-1 beta-Specific Antibody That Simultaneously Inhibits Binding to Both IL-1RI and IL-1RAcP. J.Mol.Biol., 433, 2020
2WRY	Crystal structure of chicken cytokine interleukin 1 beta Descriptor: INTERLEUKIN-1BETA Authors: Lu, W.S, Cheng, C.S, Lyu, P.C, Lee, L.H, Wang, W.C, Yin, H.S. Deposit date: 2009-09-03 Release date: 2010-09-29 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.58 Å) Cite: Structural and Functional Comparison of Cytokine Interleukin-1 Beta from Chicken and Human. Mol.Immunol., 48, 2011
41BI	INTERLEUKIN-1 BETA (IL-1 BETA) (MUTANT WITH CYS 8 REPLACED BY ALA (C8A) Descriptor: INTERLEUKIN-1 BETA Authors: Veerapandian, B, Poulos, T.L, Gilliland, G.L, Masui, Y, Hirai, Y. Deposit date: 1992-02-03 Release date: 1992-04-15 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.9 Å) Cite:
8I1B	A COMPARISON OF THE HIGH RESOLUTION STRUCTURES OF HUMAN AND MURINE INTERLEUKIN-1B Descriptor: INTERLEUKIN-1 BETA Authors: Ohlendorf, D.H, Weber, P.C, Salemme, F.R. Deposit date: 1991-01-29 Release date: 1992-07-15 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.4 Å) Cite: A Comparison of the High Resolution Structures of Human and Murine Interleukin-1B To be Published
6Y8M	Fragment bikinin bound to Interleukin 1 beta Descriptor: 4-[(5-bromopyridin-2-yl)amino]-4-oxobutanoic acid, Interleukin-1 beta, SULFATE ION Authors: De Nicola, G.F, Nichols, C.E. Deposit date: 2020-03-05 Release date: 2020-03-18 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Fragment bikinin bound to Interleukin 1 beta To Be Published
6Y8I	Fragment KCL_I013 in complex with IL-1-beta Descriptor: 1-(5-bromanylpyridin-2-yl)-3-(2-hydroxyethyl)urea, Interleukin-1 beta, SULFATE ION Authors: De Nicola, G.F, Nichols, C.E. Deposit date: 2020-03-05 Release date: 2020-06-17 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.46 Å) Cite: Fragment KCL_I013 in complex with IL-1-beta To Be Published
31BI	INTERLEUKIN-1 BETA (IL-1 BETA) (MUTANT WITH CYS 71 REPLACED BY SER) (C71S) Descriptor: INTERLEUKIN-1 BETA PRECURSOR Authors: Veerapandian, B, Poulos, T.L, Gilliland, G.L, Masui, Y, Hirai, Y. Deposit date: 1991-03-21 Release date: 1992-04-15 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2 Å) Cite:
6I1B	HIGH-RESOLUTION THREE-DIMENSIONAL STRUCTURE OF INTERLEUKIN-1 BETA IN SOLUTION BY THREE-AND FOUR-DIMENSIONAL NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY Descriptor: INTERLEUKIN-1 BETA Authors: Clore, G.M, Gronenborn, A.M. Deposit date: 1991-01-22 Release date: 1992-10-15 Last modified: 2022-03-16 Method: SOLUTION NMR Cite: High-resolution three-dimensional structure of interleukin 1 beta in solution by three- and four-dimensional nuclear magnetic resonance spectroscopy. Biochemistry, 30, 1991
5BOW	CRYSTAL STRUCTURE OF IL-38 Descriptor: 1,2-ETHANEDIOL, Interleukin-1 family member 10 Authors: Guenther, S, Sundberg, E.J. Deposit date: 2015-05-27 Release date: 2016-06-01 Last modified: 2017-11-22 Method: X-RAY DIFFRACTION (1.31 Å) Cite: Crystal Structure of Interleukin-38 To Be Published

 

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