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4XCR
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BU of 4xcr by Molmil
Monomeric Human Cu,Zn Superoxide dismutase, loops IV and VII deleted, apo form, mutant I35A
Descriptor: Superoxide dismutase [Cu-Zn]
Authors:Wang, H, Logan, D.T, Danielsson, J, Mu, X, Binolfi, A, Theillet, F, Bekei, B, Lang, L, Wennerstrom, H, Selenko, P, Oliveberg, M.
Deposit date:2014-12-18
Release date:2016-01-20
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.602 Å)
Cite:Thermodynamics of protein destabilization in live cells.
Proc. Natl. Acad. Sci. U.S.A., 112, 2015
2K4W
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BU of 2k4w by Molmil
The Solution Structure of the Monomeric Copper, Zinc Superoxide Dismutase from Salmonella enterica
Descriptor: COPPER (I) ION, Superoxide dismutase [Cu-Zn], ZINC ION
Authors:Mori, M, Jimenez, B, Piccioli, M, Battistoni, A, Sette, M, Structural Proteomics in Europe (SPINE)
Deposit date:2008-06-20
Release date:2008-11-18
Last modified:2021-10-20
Method:SOLUTION NMR
Cite:The Solution Structure of the Monomeric Copper, Zinc Superoxide Dismutase from Salmonella enterica: Structural Insights To Understand the Evolution toward the Dimeric Structure.
Biochemistry, 47, 2008
8CCX
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BU of 8ccx by Molmil
Human SOD1 in complex with S-XL6 cross-linker
Descriptor: COPPER (II) ION, DIMETHYL SULFOXIDE, SULFATE ION, ...
Authors:Antonyuk, S.V, Hossain, A, Agar, J.N, Hasnain, S.S.
Deposit date:2023-01-27
Release date:2023-12-13
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.665 Å)
Cite:Evaluating protein cross-linking as a therapeutic strategy to stabilize SOD1 variants in a mouse model of familial ALS.
Plos Biol., 22, 2024
4MCM
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BU of 4mcm by Molmil
Human SOD1 C57S Mutant, As-isolated
Descriptor: SULFATE ION, Superoxide dismutase [Cu-Zn], ZINC ION
Authors:Sea, K, Sohn, S.H, Durazo, A, Sheng, Y, Shaw, B, Cao, X, Taylor, A.B, Whitson, L.J, Holloway, S.P, Hart, P.J, Cabelli, D.E, Gralla, E.B, Valentine, J.S.
Deposit date:2013-08-21
Release date:2014-08-27
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Insights into the role of the unusual disulfide bond in copper-zinc superoxide dismutase.
J.Biol.Chem., 290, 2015
7NXX
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BU of 7nxx by Molmil
Structure of Superoxide Dismutase 1 (SOD1) in complex with nanobody 2 (Nb2).
Descriptor: COPPER (II) ION, Superoxide dismutase [Cu-Zn], ZINC ION, ...
Authors:Gallardo, R, Rousseau, F, Schymkowitz, J, Ulens, C.
Deposit date:2021-03-19
Release date:2022-09-28
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.189 Å)
Cite:Identification and rational improvement of a nanobody that suppresses aggregation of mutant SOD1
To Be Published
5CU9
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BU of 5cu9 by Molmil
CANDIDA ALBICANS SUPEROXIDE DISMUTASE 5 (SOD5), APO
Descriptor: Cell surface Cu-only superoxide dismutase 5, SULFATE ION
Authors:Waninger-Saroni, J.J, Taylor, A.B, Hart, P.J, Galaleldeen, A.
Deposit date:2015-07-24
Release date:2016-07-27
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:CANDIDA ALBICANS SUPEROXIDE DISMUTASE 5 (SOD5), APO
To Be Published
8GSQ
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BU of 8gsq by Molmil
Structure based studies reveal an atypical antipsychotic drug candidate - Paliperidone as a potent hSOD1 modulator with implications in ALS treatment.
Descriptor: (9~{R})-3-[2-[4-(6-fluoranyl-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-9-oxidanyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one, GLYCEROL, Superoxide dismutase [Cu-Zn], ...
Authors:Aouti, S, Padmanabhan, B.
Deposit date:2022-09-06
Release date:2023-06-14
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure-based discovery of an antipsychotic drug, paliperidone, as a modulator of human superoxide dismutase 1: a potential therapeutic target in amyotrophic lateral sclerosis.
Acta Crystallogr D Struct Biol, 79, 2023
5IN2
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BU of 5in2 by Molmil
Crystal structure of extra cellular Cu/Zn Superoxide Dismutase from Onchocerca volvulus at 1.5 Angstrom; Insight into novel binding site and new inhibitors
Descriptor: AZIDE ION, CHLORIDE ION, COPPER (II) ION, ...
Authors:Moustafa, A, Betzel, C, Perbandt, M.
Deposit date:2016-03-07
Release date:2017-03-29
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal structure of extracellular Cu/Zn Superoxide Dismutase from Onchocerca volvulus at 1.5 Angstrom; Insight into novel binding site and new inhibitors
To Be Published
4FF9
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BU of 4ff9 by Molmil
Crystal Structure of cysteinylated WT SOD1.
Descriptor: COPPER (II) ION, CYSTEINE, Superoxide dismutase [Cu-Zn], ...
Authors:Auclair, J.R, Brodkin, H.R, D'Aquino, J.A, Ringe, D, Petsko, G.A, Agar, J.N.
Deposit date:2012-05-31
Release date:2013-09-04
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.5003 Å)
Cite:Structural consequences of cysteinylation of cu/zn-superoxide dismutase.
Biochemistry, 52, 2013
4L05
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BU of 4l05 by Molmil
Cu/Zn superoxide dismutase from Brucella abortus
Descriptor: COPPER (I) ION, COPPER (II) ION, GLYCEROL, ...
Authors:Shin, D.S, Didonato, M, Pratt, A.J, Bruns, C.K, Cabelli, D.E, Kroll, J.S, Belzer, C.A, Tabatabai, L.B, Tainer, J.A, Getzoff, E.D.
Deposit date:2013-05-30
Release date:2013-10-23
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.098 Å)
Cite:Structural, Functional, and Immunogenic Insights on Cu,Zn Superoxide Dismutase Pathogenic Virulence Factors from Neisseria meningitidis and Brucella abortus.
J.Bacteriol., 197, 2015
2WZ0
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BU of 2wz0 by Molmil
L38V SOD1 mutant complexed with aniline.
Descriptor: 2-METHOXY-5-METHYLANILINE, COPPER (II) ION, D-SERINE, ...
Authors:Antonyuk, S, Strange, R.W, Hasnain, S.S.
Deposit date:2009-11-20
Release date:2010-12-08
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Structural Discovery of Small Molecule Binding Sites in Cu-Zn Human Superoxide Dismutase Familial Amyotrophic Lateral Sclerosis Mutants Provides Insights for Lead Optimization.
J.Med.Chem., 53, 2010
2XJL
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BU of 2xjl by Molmil
Monomeric Human Cu,Zn Superoxide dismutase without Cu ligands
Descriptor: ACETATE ION, DI(HYDROXYETHYL)ETHER, SODIUM ION, ...
Authors:Saraboji, K, Leinartaite, L, Nordlund, A, Oliveberg, M, Logan, D.T.
Deposit date:2010-07-07
Release date:2010-09-01
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Folding Catalysis by Transient Coordination of Zn2+ to the Cu Ligands of the Als-Associated Enzyme Cu/Zn Superoxide Dismutase 1.
J.Am.Chem.Soc., 132, 2010
7YPP
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BU of 7ypp by Molmil
Structural basis of a superoxide dismutase from a tardigrade, Ramazzottius varieornatus strain YOKOZUNA-1.
Descriptor: CALCIUM ION, COPPER (II) ION, Superoxide dismutase [Cu-Zn], ...
Authors:Sim, K.-S, Fukuda, Y, Inoue, T.
Deposit date:2022-08-04
Release date:2023-07-26
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of a superoxide dismutase from a tardigrade: Ramazzottius varieornatus strain YOKOZUNA-1.
Acta Crystallogr.,Sect.F, 79, 2023
7B4O
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BU of 7b4o by Molmil
A Bacteroidetes bacterium CuZn-superoxide dismutase with ZnZn metalation
Descriptor: Superoxide dismutase [Cu-Zn], ZINC ION
Authors:Wright, G.S.A.
Deposit date:2020-12-02
Release date:2021-06-02
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.41 Å)
Cite:Bacterial Evolutionary Precursors of Eukaryotic Copper-Zinc Superoxide Dismutases.
Mol.Biol.Evol., 38, 2021
7YPR
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BU of 7ypr by Molmil
Structural basis of a superoxide dismutase from a tardigrade, Ramazzottius varieornatus strain YOKOZUNA-1.
Descriptor: COPPER (II) ION, POTASSIUM ION, Superoxide dismutase [Cu-Zn], ...
Authors:Sim, K.-S, Fukuda, Y, Inoue, T.
Deposit date:2022-08-04
Release date:2023-12-06
Method:X-RAY DIFFRACTION (2.101 Å)
Cite:Structure of a superoxide dismutase from a tardigrade: Ramazzottius varieornatus strain YOKOZUNA-1.
Acta Crystallogr.,Sect.F, 79, 2023
7B4P
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BU of 7b4p by Molmil
A Bacteroidetes bacterium CuZn-superoxide dismutase with CuZn metalation
Descriptor: COPPER (II) ION, Superoxide dismutase [Cu-Zn], ZINC ION
Authors:Wright, G.S.A.
Deposit date:2020-12-02
Release date:2021-06-02
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Bacterial Evolutionary Precursors of Eukaryotic Copper-Zinc Superoxide Dismutases.
Mol.Biol.Evol., 38, 2021
7FB6
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BU of 7fb6 by Molmil
C57D/C146D mutant of Human Cu, Zn Superoxide Dismutase (SOD1)
Descriptor: CHLORIDE ION, COPPER (II) ION, Superoxide dismutase [Cu-Zn], ...
Authors:Baek, Y, Ha, N.-C.
Deposit date:2021-07-08
Release date:2022-10-12
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural analysis of the overoxidized Cu/Zn-superoxide dismutase in ROS-induced ALS filament formation.
Commun Biol, 5, 2022
7FB9
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BU of 7fb9 by Molmil
Crystal Structure of Human Cu, Zn Superoxide Dismutase (SOD1)
Descriptor: COPPER (II) ION, Superoxide dismutase [Cu-Zn], ZINC ION
Authors:Baek, Y, Ha, N.-C.
Deposit date:2021-07-08
Release date:2022-10-12
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural analysis of the overoxidized Cu/Zn-superoxide dismutase in ROS-induced ALS filament formation.
Commun Biol, 5, 2022
6DTK
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BU of 6dtk by Molmil
Heterodimers of FALS mutant SOD enzyme
Descriptor: COPPER (II) ION, MALONATE ION, Superoxide dismutase C111S/D83S-C111S HETERODIMER, ...
Authors:Streltsov, V.A, Nuttall, S.D, Ganio, K.E, Roberts, B.
Deposit date:2018-06-17
Release date:2019-06-19
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural characterization of heterodimers of FALS mutant SOD enzyme
To Be Published
5O40
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BU of 5o40 by Molmil
SOD1 bound to Ebselen
Descriptor: N-phenyl-2-selanylbenzamide, SULFATE ION, Superoxide dismutase [Cu-Zn], ...
Authors:Capper, M.J, Wright, G.S.A, Antonyuk, S.V, Hasnain, S.S.
Deposit date:2017-05-25
Release date:2018-06-13
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation.
Nat Commun, 9, 2018
7CJV
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BU of 7cjv by Molmil
Solution structure of monomeric superoxide dismutase 1 with an additional mutation H46W in a dilute environment
Descriptor: Monomeric Human Cu,Zn Superoxide dismutase
Authors:Iwakawa, N, Morimoto, D, Walinda, E, Danielsson, J, Shirakawa, M, Sugase, K.
Deposit date:2020-07-14
Release date:2021-05-26
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Transient Diffusive Interactions with a Protein Crowder Affect Aggregation Processes of Superoxide Dismutase 1 beta-Barrel.
J.Phys.Chem.B, 125, 2021
5O3Y
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BU of 5o3y by Molmil
SOD1 bound to Ebsulfur
Descriptor: SULFATE ION, Superoxide dismutase [Cu-Zn], ZINC ION, ...
Authors:Capper, M.J, Wright, G.S.A, Antonyuk, S.V, Hasnain, S.S.
Deposit date:2017-05-25
Release date:2018-06-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation.
Nat Commun, 9, 2018
4RVP
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BU of 4rvp by Molmil
Crystal structure of superoxide dismutase from sedum alfredii
Descriptor: ZINC ION, superoxide dismutase
Authors:Qiu, R, Li, C, Zhai, J, Tang, L, Zhang, H, Yuan, M, Hu, X.
Deposit date:2014-11-27
Release date:2015-12-16
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The positive effects of Cd and Cd-Zn relationship in the Zn-related physiological processes involved in growth in the Zn/Cd hyperaccumulator Sedum alfredii
To be Published
8YD3
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BU of 8yd3 by Molmil
Crystal structure of human Cu-Zn Superoxide Dismutase 1 in complex with 1,2,10-Decanetriol
Descriptor: (2S)-decane-1,2,10-triol, GLYCEROL, Superoxide dismutase [Cu-Zn], ...
Authors:Aouti, S, Padmanabhan, B.
Deposit date:2024-02-19
Release date:2024-08-21
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Crystal structure of human Cu-Zn Superoxide Dismutase 1 in complex with 1,2,10-Decanetriol
To Be Published
7CJW
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BU of 7cjw by Molmil
Solution structure of monomeric superoxide dismutase 1 with an additional mutation H46W in a crowded environment
Descriptor: Monomeric Human Cu,Zn Superoxide dismutase
Authors:Iwakawa, N, Morimoto, D, Walinda, E, Danielsson, J, Shirakawa, M, Sugase, K.
Deposit date:2020-07-14
Release date:2021-05-26
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Transient Diffusive Interactions with a Protein Crowder Affect Aggregation Processes of Superoxide Dismutase 1 beta-Barrel.
J.Phys.Chem.B, 125, 2021

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