8XU4
The Crystal Structure of MAPK2 from Biortus.
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 24 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGLGINGKVLqIfnkrtqek..........FALK |
| Chain | Residue | Details |
| A | LEU70-LYS93 |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IaHrDVKpeNLLY |
| Chain | Residue | Details |
| A | ILE182-TYR194 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | ACT_SITE: Proton acceptor |
| Chain | Residue | Details |
| A | ASP186 | |
| B | ASP186 | |
| C | ASP186 | |
| D | ASP186 | |
| E | ASP186 | |
| F | ASP186 | |
| G | ASP186 | |
| H | ASP186 | |
| I | ASP186 | |
| J | ASP186 | |
| K | ASP186 | |
| L | ASP186 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 |
| Chain | Residue | Details |
| A | LEU70 | |
| A | LYS93 | |
| B | LEU70 | |
| B | LYS93 | |
| C | LEU70 | |
| C | LYS93 | |
| D | LEU70 | |
| D | LYS93 | |
| E | LEU70 | |
| E | LYS93 | |
| F | LEU70 | |
| F | LYS93 | |
| G | LEU70 | |
| G | LYS93 | |
| H | LEU70 | |
| H | LYS93 | |
| I | LEU70 | |
| I | LYS93 | |
| J | LEU70 | |
| J | LYS93 | |
| K | LEU70 | |
| K | LYS93 | |
| L | LEU70 | |
| L | LYS93 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | GLU139 | |
| B | GLU139 | |
| C | GLU139 | |
| D | GLU139 | |
| E | GLU139 | |
| F | GLU139 | |
| G | GLU139 | |
| H | GLU139 | |
| I | GLU139 | |
| J | GLU139 | |
| K | GLU139 | |
| L | GLU139 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | MOD_RES: Phosphothreonine; by MAPK14 => ECO:0000269|PubMed:8846784 |
| Chain | Residue | Details |
| A | THR222 | |
| B | THR222 | |
| C | THR222 | |
| D | THR222 | |
| E | THR222 | |
| F | THR222 | |
| G | THR222 | |
| H | THR222 | |
| I | THR222 | |
| J | THR222 | |
| K | THR222 | |
| L | THR222 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 12 |
| Details | MOD_RES: Phosphoserine; by MAPK14 => ECO:0000269|PubMed:8846784 |
| Chain | Residue | Details |
| A | SER272 | |
| B | SER272 | |
| C | SER272 | |
| D | SER272 | |
| E | SER272 | |
| F | SER272 | |
| G | SER272 | |
| H | SER272 | |
| I | SER272 | |
| J | SER272 | |
| K | SER272 | |
| L | SER272 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 12 |
| Details | MOD_RES: Phosphoserine; by autocatalysis => ECO:0000250 |
| Chain | Residue | Details |
| A | SER328 | |
| B | SER328 | |
| C | SER328 | |
| D | SER328 | |
| E | SER328 | |
| F | SER328 | |
| G | SER328 | |
| H | SER328 | |
| I | SER328 | |
| J | SER328 | |
| K | SER328 | |
| L | SER328 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 12 |
| Details | MOD_RES: Phosphothreonine; by MAPK14 => ECO:0000269|PubMed:8846784, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | THR334 | |
| B | THR334 | |
| C | THR334 | |
| D | THR334 | |
| E | THR334 | |
| F | THR334 | |
| G | THR334 | |
| H | THR334 | |
| I | THR334 | |
| J | THR334 | |
| K | THR334 | |
| L | THR334 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 24 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:21131586 |
| Chain | Residue | Details |
| A | LYS353 | |
| B | LYS353 | |
| C | LYS353 | |
| D | LYS353 | |
| E | LYS353 | |
| F | LYS353 | |
| G | LYS353 | |
| H | LYS353 | |
| I | LYS353 | |
| J | LYS353 | |
| K | LYS353 | |
| L | LYS353 |
