8WUW

Cryo-EM structure of H. thermophilus GroEL-GroES2 asymmetric football complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0009408	biological_process	response to heat
A	0016853	molecular_function	isomerase activity
A	0032727	biological_process	positive regulation of interferon-alpha production
A	0032729	biological_process	positive regulation of type II interferon production
A	0032755	biological_process	positive regulation of interleukin-6 production
A	0034514	biological_process	mitochondrial unfolded protein response
A	0042026	biological_process	protein refolding
A	0045041	biological_process	protein import into mitochondrial intermembrane space
A	0050870	biological_process	positive regulation of T cell activation
A	0051082	molecular_function	unfolded protein binding
A	0051085	biological_process	chaperone cofactor-dependent protein refolding
A	0051087	molecular_function	protein-folding chaperone binding
A	1990220	cellular_component	GroEL-GroES complex
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0009408	biological_process	response to heat
B	0016853	molecular_function	isomerase activity
B	0032727	biological_process	positive regulation of interferon-alpha production
B	0032729	biological_process	positive regulation of type II interferon production
B	0032755	biological_process	positive regulation of interleukin-6 production
B	0034514	biological_process	mitochondrial unfolded protein response
B	0042026	biological_process	protein refolding
B	0045041	biological_process	protein import into mitochondrial intermembrane space
B	0050870	biological_process	positive regulation of T cell activation
B	0051082	molecular_function	unfolded protein binding
B	0051085	biological_process	chaperone cofactor-dependent protein refolding
B	0051087	molecular_function	protein-folding chaperone binding
B	1990220	cellular_component	GroEL-GroES complex
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0009408	biological_process	response to heat
C	0016853	molecular_function	isomerase activity
C	0032727	biological_process	positive regulation of interferon-alpha production
C	0032729	biological_process	positive regulation of type II interferon production
C	0032755	biological_process	positive regulation of interleukin-6 production
C	0034514	biological_process	mitochondrial unfolded protein response
C	0042026	biological_process	protein refolding
C	0045041	biological_process	protein import into mitochondrial intermembrane space
C	0050870	biological_process	positive regulation of T cell activation
C	0051082	molecular_function	unfolded protein binding
C	0051085	biological_process	chaperone cofactor-dependent protein refolding
C	0051087	molecular_function	protein-folding chaperone binding
C	1990220	cellular_component	GroEL-GroES complex
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0009408	biological_process	response to heat
D	0016853	molecular_function	isomerase activity
D	0032727	biological_process	positive regulation of interferon-alpha production
D	0032729	biological_process	positive regulation of type II interferon production
D	0032755	biological_process	positive regulation of interleukin-6 production
D	0034514	biological_process	mitochondrial unfolded protein response
D	0042026	biological_process	protein refolding
D	0045041	biological_process	protein import into mitochondrial intermembrane space
D	0050870	biological_process	positive regulation of T cell activation
D	0051082	molecular_function	unfolded protein binding
D	0051085	biological_process	chaperone cofactor-dependent protein refolding
D	0051087	molecular_function	protein-folding chaperone binding
D	1990220	cellular_component	GroEL-GroES complex
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0009408	biological_process	response to heat
E	0016853	molecular_function	isomerase activity
E	0032727	biological_process	positive regulation of interferon-alpha production
E	0032729	biological_process	positive regulation of type II interferon production
E	0032755	biological_process	positive regulation of interleukin-6 production
E	0034514	biological_process	mitochondrial unfolded protein response
E	0042026	biological_process	protein refolding
E	0045041	biological_process	protein import into mitochondrial intermembrane space
E	0050870	biological_process	positive regulation of T cell activation
E	0051082	molecular_function	unfolded protein binding
E	0051085	biological_process	chaperone cofactor-dependent protein refolding
E	0051087	molecular_function	protein-folding chaperone binding
E	1990220	cellular_component	GroEL-GroES complex
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0009408	biological_process	response to heat
F	0016853	molecular_function	isomerase activity
F	0032727	biological_process	positive regulation of interferon-alpha production
F	0032729	biological_process	positive regulation of type II interferon production
F	0032755	biological_process	positive regulation of interleukin-6 production
F	0034514	biological_process	mitochondrial unfolded protein response
F	0042026	biological_process	protein refolding
F	0045041	biological_process	protein import into mitochondrial intermembrane space
F	0050870	biological_process	positive regulation of T cell activation
F	0051082	molecular_function	unfolded protein binding
F	0051085	biological_process	chaperone cofactor-dependent protein refolding
F	0051087	molecular_function	protein-folding chaperone binding
F	1990220	cellular_component	GroEL-GroES complex
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0009408	biological_process	response to heat
G	0016853	molecular_function	isomerase activity
G	0032727	biological_process	positive regulation of interferon-alpha production
G	0032729	biological_process	positive regulation of type II interferon production
G	0032755	biological_process	positive regulation of interleukin-6 production
G	0034514	biological_process	mitochondrial unfolded protein response
G	0042026	biological_process	protein refolding
G	0045041	biological_process	protein import into mitochondrial intermembrane space
G	0050870	biological_process	positive regulation of T cell activation
G	0051082	molecular_function	unfolded protein binding
G	0051085	biological_process	chaperone cofactor-dependent protein refolding
G	0051087	molecular_function	protein-folding chaperone binding
G	1990220	cellular_component	GroEL-GroES complex
H	0005524	molecular_function	ATP binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0009408	biological_process	response to heat
H	0016853	molecular_function	isomerase activity
H	0032727	biological_process	positive regulation of interferon-alpha production
H	0032729	biological_process	positive regulation of type II interferon production
H	0032755	biological_process	positive regulation of interleukin-6 production
H	0034514	biological_process	mitochondrial unfolded protein response
H	0042026	biological_process	protein refolding
H	0045041	biological_process	protein import into mitochondrial intermembrane space
H	0050870	biological_process	positive regulation of T cell activation
H	0051082	molecular_function	unfolded protein binding
H	0051085	biological_process	chaperone cofactor-dependent protein refolding
H	0051087	molecular_function	protein-folding chaperone binding
H	1990220	cellular_component	GroEL-GroES complex
I	0005524	molecular_function	ATP binding
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0009408	biological_process	response to heat
I	0016853	molecular_function	isomerase activity
I	0032727	biological_process	positive regulation of interferon-alpha production
I	0032729	biological_process	positive regulation of type II interferon production
I	0032755	biological_process	positive regulation of interleukin-6 production
I	0034514	biological_process	mitochondrial unfolded protein response
I	0042026	biological_process	protein refolding
I	0045041	biological_process	protein import into mitochondrial intermembrane space
I	0050870	biological_process	positive regulation of T cell activation
I	0051082	molecular_function	unfolded protein binding
I	0051085	biological_process	chaperone cofactor-dependent protein refolding
I	0051087	molecular_function	protein-folding chaperone binding
I	1990220	cellular_component	GroEL-GroES complex
J	0005524	molecular_function	ATP binding
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0009408	biological_process	response to heat
J	0016853	molecular_function	isomerase activity
J	0032727	biological_process	positive regulation of interferon-alpha production
J	0032729	biological_process	positive regulation of type II interferon production
J	0032755	biological_process	positive regulation of interleukin-6 production
J	0034514	biological_process	mitochondrial unfolded protein response
J	0042026	biological_process	protein refolding
J	0045041	biological_process	protein import into mitochondrial intermembrane space
J	0050870	biological_process	positive regulation of T cell activation
J	0051082	molecular_function	unfolded protein binding
J	0051085	biological_process	chaperone cofactor-dependent protein refolding
J	0051087	molecular_function	protein-folding chaperone binding
J	1990220	cellular_component	GroEL-GroES complex
K	0005524	molecular_function	ATP binding
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0009408	biological_process	response to heat
K	0016853	molecular_function	isomerase activity
K	0032727	biological_process	positive regulation of interferon-alpha production
K	0032729	biological_process	positive regulation of type II interferon production
K	0032755	biological_process	positive regulation of interleukin-6 production
K	0034514	biological_process	mitochondrial unfolded protein response
K	0042026	biological_process	protein refolding
K	0045041	biological_process	protein import into mitochondrial intermembrane space
K	0050870	biological_process	positive regulation of T cell activation
K	0051082	molecular_function	unfolded protein binding
K	0051085	biological_process	chaperone cofactor-dependent protein refolding
K	0051087	molecular_function	protein-folding chaperone binding
K	1990220	cellular_component	GroEL-GroES complex
L	0005524	molecular_function	ATP binding
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0009408	biological_process	response to heat
L	0016853	molecular_function	isomerase activity
L	0032727	biological_process	positive regulation of interferon-alpha production
L	0032729	biological_process	positive regulation of type II interferon production
L	0032755	biological_process	positive regulation of interleukin-6 production
L	0034514	biological_process	mitochondrial unfolded protein response
L	0042026	biological_process	protein refolding
L	0045041	biological_process	protein import into mitochondrial intermembrane space
L	0050870	biological_process	positive regulation of T cell activation
L	0051082	molecular_function	unfolded protein binding
L	0051085	biological_process	chaperone cofactor-dependent protein refolding
L	0051087	molecular_function	protein-folding chaperone binding
L	1990220	cellular_component	GroEL-GroES complex
M	0005524	molecular_function	ATP binding
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0009408	biological_process	response to heat
M	0016853	molecular_function	isomerase activity
M	0032727	biological_process	positive regulation of interferon-alpha production
M	0032729	biological_process	positive regulation of type II interferon production
M	0032755	biological_process	positive regulation of interleukin-6 production
M	0034514	biological_process	mitochondrial unfolded protein response
M	0042026	biological_process	protein refolding
M	0045041	biological_process	protein import into mitochondrial intermembrane space
M	0050870	biological_process	positive regulation of T cell activation
M	0051082	molecular_function	unfolded protein binding
M	0051085	biological_process	chaperone cofactor-dependent protein refolding
M	0051087	molecular_function	protein-folding chaperone binding
M	1990220	cellular_component	GroEL-GroES complex
N	0005524	molecular_function	ATP binding
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0009408	biological_process	response to heat
N	0016853	molecular_function	isomerase activity
N	0032727	biological_process	positive regulation of interferon-alpha production
N	0032729	biological_process	positive regulation of type II interferon production
N	0032755	biological_process	positive regulation of interleukin-6 production
N	0034514	biological_process	mitochondrial unfolded protein response
N	0042026	biological_process	protein refolding
N	0045041	biological_process	protein import into mitochondrial intermembrane space
N	0050870	biological_process	positive regulation of T cell activation
N	0051082	molecular_function	unfolded protein binding
N	0051085	biological_process	chaperone cofactor-dependent protein refolding
N	0051087	molecular_function	protein-folding chaperone binding
N	1990220	cellular_component	GroEL-GroES complex
a	0005737	cellular_component	cytoplasm
a	0006457	biological_process	protein folding
a	0046872	molecular_function	metal ion binding
a	0051082	molecular_function	unfolded protein binding
a	0051085	biological_process	chaperone cofactor-dependent protein refolding
a	0051087	molecular_function	protein-folding chaperone binding
b	0005737	cellular_component	cytoplasm
b	0006457	biological_process	protein folding
b	0046872	molecular_function	metal ion binding
b	0051082	molecular_function	unfolded protein binding
b	0051085	biological_process	chaperone cofactor-dependent protein refolding
b	0051087	molecular_function	protein-folding chaperone binding
c	0005737	cellular_component	cytoplasm
c	0006457	biological_process	protein folding
c	0046872	molecular_function	metal ion binding
c	0051082	molecular_function	unfolded protein binding
c	0051085	biological_process	chaperone cofactor-dependent protein refolding
c	0051087	molecular_function	protein-folding chaperone binding
d	0005737	cellular_component	cytoplasm
d	0006457	biological_process	protein folding
d	0046872	molecular_function	metal ion binding
d	0051082	molecular_function	unfolded protein binding
d	0051085	biological_process	chaperone cofactor-dependent protein refolding
d	0051087	molecular_function	protein-folding chaperone binding
e	0005737	cellular_component	cytoplasm
e	0006457	biological_process	protein folding
e	0046872	molecular_function	metal ion binding
e	0051082	molecular_function	unfolded protein binding
e	0051085	biological_process	chaperone cofactor-dependent protein refolding
e	0051087	molecular_function	protein-folding chaperone binding
f	0005737	cellular_component	cytoplasm
f	0006457	biological_process	protein folding
f	0046872	molecular_function	metal ion binding
f	0051082	molecular_function	unfolded protein binding
f	0051085	biological_process	chaperone cofactor-dependent protein refolding
f	0051087	molecular_function	protein-folding chaperone binding
g	0005737	cellular_component	cytoplasm
g	0006457	biological_process	protein folding
g	0046872	molecular_function	metal ion binding
g	0051082	molecular_function	unfolded protein binding
g	0051085	biological_process	chaperone cofactor-dependent protein refolding
g	0051087	molecular_function	protein-folding chaperone binding
h	0005737	cellular_component	cytoplasm
h	0006457	biological_process	protein folding
h	0046872	molecular_function	metal ion binding
h	0051082	molecular_function	unfolded protein binding
h	0051085	biological_process	chaperone cofactor-dependent protein refolding
h	0051087	molecular_function	protein-folding chaperone binding
i	0005737	cellular_component	cytoplasm
i	0006457	biological_process	protein folding
i	0046872	molecular_function	metal ion binding
i	0051082	molecular_function	unfolded protein binding
i	0051085	biological_process	chaperone cofactor-dependent protein refolding
i	0051087	molecular_function	protein-folding chaperone binding
j	0005737	cellular_component	cytoplasm
j	0006457	biological_process	protein folding
j	0046872	molecular_function	metal ion binding
j	0051082	molecular_function	unfolded protein binding
j	0051085	biological_process	chaperone cofactor-dependent protein refolding
j	0051087	molecular_function	protein-folding chaperone binding
k	0005737	cellular_component	cytoplasm
k	0006457	biological_process	protein folding
k	0046872	molecular_function	metal ion binding
k	0051082	molecular_function	unfolded protein binding
k	0051085	biological_process	chaperone cofactor-dependent protein refolding
k	0051087	molecular_function	protein-folding chaperone binding
l	0005737	cellular_component	cytoplasm
l	0006457	biological_process	protein folding
l	0046872	molecular_function	metal ion binding
l	0051082	molecular_function	unfolded protein binding
l	0051085	biological_process	chaperone cofactor-dependent protein refolding
l	0051087	molecular_function	protein-folding chaperone binding
m	0005737	cellular_component	cytoplasm
m	0006457	biological_process	protein folding
m	0046872	molecular_function	metal ion binding
m	0051082	molecular_function	unfolded protein binding
m	0051085	biological_process	chaperone cofactor-dependent protein refolding
m	0051087	molecular_function	protein-folding chaperone binding
n	0005737	cellular_component	cytoplasm
n	0006457	biological_process	protein folding
n	0046872	molecular_function	metal ion binding
n	0051082	molecular_function	unfolded protein binding
n	0051085	biological_process	chaperone cofactor-dependent protein refolding
n	0051087	molecular_function	protein-folding chaperone binding

Functional Information from PROSITE/UniProt

site_id	PS00296
Number of Residues	12
Details	CHAPERONINS_CPN60 Chaperonins cpn60 signature. AAVEEGIVpGGG

Chain	Residue	Details
A	ALA405-GLY416

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