8TXE
Crystal structure of KRAS G12D in complex with GDP and compound 5
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003924 | molecular_function | GTPase activity |
A | 0005525 | molecular_function | GTP binding |
A | 0007165 | biological_process | signal transduction |
A | 0016020 | cellular_component | membrane |
B | 0003924 | molecular_function | GTPase activity |
B | 0005525 | molecular_function | GTP binding |
B | 0007165 | biological_process | signal transduction |
B | 0016020 | cellular_component | membrane |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000269|PubMed:22431598, ECO:0000269|PubMed:22566140 |
Chain | Residue | Details |
A | GLY10 | |
A | VAL29 | |
A | ALA59 | |
A | ASN116 | |
B | GLY10 | |
B | VAL29 | |
B | ALA59 | |
B | ASN116 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | MOD_RES: N-acetylmethionine; in GTPase KRas; alternate => ECO:0000269|Ref.17 |
Chain | Residue | Details |
A | MET1 | |
B | MET1 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | MOD_RES: N-acetylthreonine; in GTPase KRas, N-terminally processed => ECO:0000269|Ref.17 |
Chain | Residue | Details |
A | THR2 | |
B | THR2 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:22711838 |
Chain | Residue | Details |
A | LYS104 | |
B | LYS104 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | CARBOHYD: (Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL => ECO:0000269|PubMed:19744486 |
Chain | Residue | Details |
A | THR35 | |
B | THR35 |