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8TXE

Crystal structure of KRAS G12D in complex with GDP and compound 5

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)
GTPase KRaspolymer17019386.82UniProt (P01116)
Pfam (PF00071)
Homo sapiens (human)K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras
2C, F
(A, B)
GUANOSINE-5'-DIPHOSPHATEnon-polymer443.22Chemie (GDP)
3D, G
(A, B)
MAGNESIUM IONnon-polymer24.32Chemie (MG)
4E, H
(A, B)
(6M)-6-(6-chloro-4-[(1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-{[(2R,4R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy}quinazolin-7-yl)-4-methyl-5-(trifluoromethyl)pyridin-2-aminenon-polymer624.02Chemie (VM9)
5I, J
(A, B)
waterwater18.0342Chemie (HOH)
Sequence modifications
A, B: 1 - 169 (UniProt: P01116)
PDBExternal DatabaseDetails
Gly 0-expression tag
Asp 12Gly 12variant
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight38773.7
Non-Polymers*Number of molecules6
Total formula weight2183.1
All*Total formula weight40956.8
*Water molecules are not included.

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PDB entries from 2024-10-30

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