8SI2
Cryo-EM structure of TRPM7 in MSP2N2 nanodisc in apo state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0051262 | biological_process | protein tetramerization |
| A | 0055085 | biological_process | transmembrane transport |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0016020 | cellular_component | membrane |
| B | 0051262 | biological_process | protein tetramerization |
| B | 0055085 | biological_process | transmembrane transport |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0016020 | cellular_component | membrane |
| C | 0051262 | biological_process | protein tetramerization |
| C | 0055085 | biological_process | transmembrane transport |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0016020 | cellular_component | membrane |
| D | 0051262 | biological_process | protein tetramerization |
| D | 0055085 | biological_process | transmembrane transport |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 480 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN756-TYR776 | |
| A | PHE856-VAL876 | |
| A | TRP919-PHE939 | |
| A | LEU963-ASN983 | |
| A | MET996-VAL1016 | |
| A | PHE1075-PHE1095 | |
| B | ASN756-TYR776 | |
| B | PHE856-VAL876 | |
| B | TRP919-PHE939 | |
| B | LEU963-ASN983 | |
| B | MET996-VAL1016 | |
| B | PHE1075-PHE1095 | |
| C | ASN756-TYR776 | |
| C | PHE856-VAL876 | |
| C | TRP919-PHE939 | |
| C | LEU963-ASN983 | |
| C | MET996-VAL1016 | |
| C | PHE1075-PHE1095 | |
| D | ASN756-TYR776 | |
| D | PHE856-VAL876 | |
| D | TRP919-PHE939 | |
| D | LEU963-ASN983 | |
| D | MET996-VAL1016 | |
| D | PHE1075-PHE1095 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 540 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| A | LYS777-LYS855 | |
| A | GLY940-ARG962 | |
| A | PRO1017-ASP1035 | |
| A | ALA1057-PRO1074 | |
| B | LYS777-LYS855 | |
| B | GLY940-ARG962 | |
| B | PRO1017-ASP1035 | |
| B | ALA1057-PRO1074 | |
| C | LYS777-LYS855 | |
| C | GLY940-ARG962 | |
| C | PRO1017-ASP1035 | |
| C | ALA1057-PRO1074 | |
| D | LYS777-LYS855 | |
| D | GLY940-ARG962 | |
| D | PRO1017-ASP1035 | |
| D | ALA1057-PRO1074 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 208 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | LYS877-VAL918 | |
| A | GLN984-LYS995 | |
| B | LYS877-VAL918 | |
| B | GLN984-LYS995 | |
| C | LYS877-VAL918 | |
| C | GLN984-LYS995 | |
| D | LYS877-VAL918 | |
| D | GLN984-LYS995 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 80 |
| Details | INTRAMEM: Pore-forming => ECO:0000255 |
| Chain | Residue | Details |
| A | ILE1036-CYS1056 | |
| B | ILE1036-CYS1056 | |
| C | ILE1036-CYS1056 | |
| D | ILE1036-CYS1056 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q96QT4 |
| Chain | Residue | Details |
| A | SER101 | |
| B | SER101 | |
| C | SER101 | |
| D | SER101 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:22222377 |
| Chain | Residue | Details |
| A | SER1224 | |
| B | SER1224 | |
| C | SER1224 | |
| D | SER1224 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:21183079 |
| Chain | Residue | Details |
| A | SER1255 | |
| B | SER1255 | |
| C | SER1255 | |
| D | SER1255 |
