8SBR

E coli. CTP synthase in complex with CTP (sodium malonate + 20 mM MgCl2)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0003883	molecular_function	CTP synthase activity
A	0004359	molecular_function	glutaminase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0006241	biological_process	CTP biosynthetic process
A	0006541	biological_process	glutamine metabolic process
A	0016874	molecular_function	ligase activity
A	0019856	biological_process	pyrimidine nucleobase biosynthetic process
A	0032991	cellular_component	protein-containing complex
A	0042802	molecular_function	identical protein binding
A	0044210	biological_process	'de novo' CTP biosynthetic process
A	0046872	molecular_function	metal ion binding
A	0051289	biological_process	protein homotetramerization
A	0097268	cellular_component	cytoophidium
B	0000287	molecular_function	magnesium ion binding
B	0003883	molecular_function	CTP synthase activity
B	0004359	molecular_function	glutaminase activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006221	biological_process	pyrimidine nucleotide biosynthetic process
B	0006241	biological_process	CTP biosynthetic process
B	0006541	biological_process	glutamine metabolic process
B	0016874	molecular_function	ligase activity
B	0019856	biological_process	pyrimidine nucleobase biosynthetic process
B	0032991	cellular_component	protein-containing complex
B	0042802	molecular_function	identical protein binding
B	0044210	biological_process	'de novo' CTP biosynthetic process
B	0046872	molecular_function	metal ion binding
B	0051289	biological_process	protein homotetramerization
B	0097268	cellular_component	cytoophidium

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Nucleophile; for glutamine hydrolysis => ECO:0000305|PubMed:11336655, ECO:0000305|PubMed:15157079

Chain	Residue	Details
A	CYS379
B	CYS379

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site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: ACT_SITE => ECO:0000305|PubMed:15157079

Chain	Residue	Details
A	HIS515
A	GLU517
B	HIS515
B	GLU517

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site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000305|PubMed:16216072

Chain	Residue	Details
A	SER14
A	LYS187
A	LYS223
B	SER14
B	LYS187
B	LYS223

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site_id	SWS_FT_FI4
Number of Residues	6
Details	BINDING: BINDING => ECO:0000305|PubMed:16216072, ECO:0007744|PDB:2AD5

Chain	Residue	Details
A	SER15
A	ASP147
A	LYS239
B	SER15
B	ASP147
B	LYS239

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site_id	SWS_FT_FI5
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:16216072, ECO:0007744|PDB:2AD5

Chain	Residue	Details
A	ASP72
A	GLU140
B	ASP72
B	GLU140

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site_id	SWS_FT_FI6
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01227

Chain	Residue	Details
A	GLY352
A	LEU380
A	GLU403
A	ARG470
B	GLY352
B	LEU380
B	GLU403
B	ARG470

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