8HF0

DmDcr-2/R2D2/LoqsPD with 50bp-dsRNA in Dimer state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002230	biological_process	positive regulation of defense response to virus by host
A	0003676	molecular_function	nucleic acid binding
A	0003723	molecular_function	RNA binding
A	0003730	molecular_function	mRNA 3'-UTR binding
A	0004386	molecular_function	helicase activity
A	0004518	molecular_function	nuclease activity
A	0004521	molecular_function	RNA endonuclease activity
A	0004525	molecular_function	ribonuclease III activity
A	0004530	molecular_function	deoxyribonuclease I activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0006309	biological_process	apoptotic DNA fragmentation
A	0006396	biological_process	RNA processing
A	0007626	biological_process	locomotory behavior
A	0008186	molecular_function	ATP-dependent activity, acting on RNA
A	0009047	biological_process	dosage compensation by hyperactivation of X chromosome
A	0009597	biological_process	detection of virus
A	0016441	biological_process	post-transcriptional gene silencing
A	0016442	cellular_component	RISC complex
A	0016443	molecular_function	bidentate ribonuclease III activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0016891	molecular_function	RNA endonuclease activity, producing 5'-phosphomonoesters
A	0030422	biological_process	siRNA processing
A	0031047	biological_process	regulatory ncRNA-mediated gene silencing
A	0031054	biological_process	pre-miRNA processing
A	0031507	biological_process	heterochromatin formation
A	0033227	biological_process	dsRNA transport
A	0035194	biological_process	regulatory ncRNA-mediated post-transcriptional gene silencing
A	0035197	molecular_function	siRNA binding
A	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
A	0045089	biological_process	positive regulation of innate immune response
A	0045752	biological_process	positive regulation of Toll signaling pathway
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0051607	biological_process	defense response to virus
A	0070578	cellular_component	RISC-loading complex
A	0070922	biological_process	RISC complex assembly
A	0098586	biological_process	cellular response to virus
A	0098795	biological_process	global gene silencing by mRNA cleavage
A	0110064	biological_process	lncRNA catabolic process
C	0003723	molecular_function	RNA binding
C	0003725	molecular_function	double-stranded RNA binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0010468	biological_process	regulation of gene expression
C	0016442	cellular_component	RISC complex
C	0030422	biological_process	siRNA processing
C	0030713	biological_process	follicle cell of egg chamber stalk formation
C	0035197	molecular_function	siRNA binding
C	0051607	biological_process	defense response to virus
C	0070578	cellular_component	RISC-loading complex
C	0070920	biological_process	regulation of regulatory ncRNA processing
C	0070922	biological_process	RISC complex assembly
D	0002230	biological_process	positive regulation of defense response to virus by host
D	0003676	molecular_function	nucleic acid binding
D	0003723	molecular_function	RNA binding
D	0003730	molecular_function	mRNA 3'-UTR binding
D	0004386	molecular_function	helicase activity
D	0004518	molecular_function	nuclease activity
D	0004521	molecular_function	RNA endonuclease activity
D	0004525	molecular_function	ribonuclease III activity
D	0004530	molecular_function	deoxyribonuclease I activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0006309	biological_process	apoptotic DNA fragmentation
D	0006396	biological_process	RNA processing
D	0007626	biological_process	locomotory behavior
D	0008186	molecular_function	ATP-dependent activity, acting on RNA
D	0009047	biological_process	dosage compensation by hyperactivation of X chromosome
D	0009597	biological_process	detection of virus
D	0016441	biological_process	post-transcriptional gene silencing
D	0016442	cellular_component	RISC complex
D	0016443	molecular_function	bidentate ribonuclease III activity
D	0016887	molecular_function	ATP hydrolysis activity
D	0016891	molecular_function	RNA endonuclease activity, producing 5'-phosphomonoesters
D	0030422	biological_process	siRNA processing
D	0031047	biological_process	regulatory ncRNA-mediated gene silencing
D	0031054	biological_process	pre-miRNA processing
D	0031507	biological_process	heterochromatin formation
D	0033227	biological_process	dsRNA transport
D	0035194	biological_process	regulatory ncRNA-mediated post-transcriptional gene silencing
D	0035197	molecular_function	siRNA binding
D	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
D	0045089	biological_process	positive regulation of innate immune response
D	0045752	biological_process	positive regulation of Toll signaling pathway
D	0048471	cellular_component	perinuclear region of cytoplasm
D	0051607	biological_process	defense response to virus
D	0070578	cellular_component	RISC-loading complex
D	0070922	biological_process	RISC complex assembly
D	0098586	biological_process	cellular response to virus
D	0098795	biological_process	global gene silencing by mRNA cleavage
D	0110064	biological_process	lncRNA catabolic process
E	0003723	molecular_function	RNA binding
E	0003725	molecular_function	double-stranded RNA binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0010468	biological_process	regulation of gene expression
E	0016442	cellular_component	RISC complex
E	0030422	biological_process	siRNA processing
E	0030713	biological_process	follicle cell of egg chamber stalk formation
E	0035197	molecular_function	siRNA binding
E	0051607	biological_process	defense response to virus
E	0070578	cellular_component	RISC-loading complex
E	0070920	biological_process	regulation of regulatory ncRNA processing
E	0070922	biological_process	RISC complex assembly

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00541

Chain	Residue	Details
A	LEU28
D	LEU28

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