8H0N

Crystal structure of the human METTL1-WDR4 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0036265	biological_process	RNA (guanine-N7)-methylation
B	0006400	biological_process	tRNA modification
B	0008176	molecular_function	tRNA (guanine(46)-N7)-methyltransferase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000305|PubMed:36599982, ECO:0000305|PubMed:36599985

Chain	Residue	Details
B	ASP134

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site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:36599982, ECO:0000269|Ref.19, ECO:0007744|PDB:3CKK, ECO:0007744|PDB:8D9L

Chain	Residue	Details
B	GLY55
B	GLU78
B	ASN111
B	THR209

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site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:36599985, ECO:0007744|PDB:8CTH

Chain	Residue	Details
B	ILE79

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site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|Ref.19, ECO:0007744|PDB:3CKK

Chain	Residue	Details
B	ARG80
B	ALA112
B	LEU131
B	GLU211

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