8GLL

R149E variant of Citrate Synthase (CitA) in Mycobacterium tuberculosis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004108	molecular_function	citrate (Si)-synthase activity
A	0005829	cellular_component	cytosol
A	0005975	biological_process	carbohydrate metabolic process
A	0006099	biological_process	tricarboxylic acid cycle
A	0016740	molecular_function	transferase activity
A	0036440	molecular_function	citrate synthase activity
A	0046912	molecular_function	acyltransferase activity, acyl groups converted into alkyl on transfer
B	0004108	molecular_function	citrate (Si)-synthase activity
B	0005829	cellular_component	cytosol
B	0005975	biological_process	carbohydrate metabolic process
B	0006099	biological_process	tricarboxylic acid cycle
B	0016740	molecular_function	transferase activity
B	0036440	molecular_function	citrate synthase activity
B	0046912	molecular_function	acyltransferase activity, acyl groups converted into alkyl on transfer
C	0004108	molecular_function	citrate (Si)-synthase activity
C	0005829	cellular_component	cytosol
C	0005975	biological_process	carbohydrate metabolic process
C	0006099	biological_process	tricarboxylic acid cycle
C	0016740	molecular_function	transferase activity
C	0036440	molecular_function	citrate synthase activity
C	0046912	molecular_function	acyltransferase activity, acyl groups converted into alkyl on transfer
D	0004108	molecular_function	citrate (Si)-synthase activity
D	0005829	cellular_component	cytosol
D	0005975	biological_process	carbohydrate metabolic process
D	0006099	biological_process	tricarboxylic acid cycle
D	0016740	molecular_function	transferase activity
D	0036440	molecular_function	citrate synthase activity
D	0046912	molecular_function	acyltransferase activity, acyl groups converted into alkyl on transfer
E	0004108	molecular_function	citrate (Si)-synthase activity
E	0005829	cellular_component	cytosol
E	0005975	biological_process	carbohydrate metabolic process
E	0006099	biological_process	tricarboxylic acid cycle
E	0016740	molecular_function	transferase activity
E	0036440	molecular_function	citrate synthase activity
E	0046912	molecular_function	acyltransferase activity, acyl groups converted into alkyl on transfer
F	0004108	molecular_function	citrate (Si)-synthase activity
F	0005829	cellular_component	cytosol
F	0005975	biological_process	carbohydrate metabolic process
F	0006099	biological_process	tricarboxylic acid cycle
F	0016740	molecular_function	transferase activity
F	0036440	molecular_function	citrate synthase activity
F	0046912	molecular_function	acyltransferase activity, acyl groups converted into alkyl on transfer
G	0004108	molecular_function	citrate (Si)-synthase activity
G	0005829	cellular_component	cytosol
G	0005975	biological_process	carbohydrate metabolic process
G	0006099	biological_process	tricarboxylic acid cycle
G	0016740	molecular_function	transferase activity
G	0036440	molecular_function	citrate synthase activity
G	0046912	molecular_function	acyltransferase activity, acyl groups converted into alkyl on transfer
H	0004108	molecular_function	citrate (Si)-synthase activity
H	0005829	cellular_component	cytosol
H	0005975	biological_process	carbohydrate metabolic process
H	0006099	biological_process	tricarboxylic acid cycle
H	0016740	molecular_function	transferase activity
H	0036440	molecular_function	citrate synthase activity
H	0046912	molecular_function	acyltransferase activity, acyl groups converted into alkyl on transfer

Functional Information from PROSITE/UniProt

site_id	PS00480
Number of Residues	13
Details	CITRATE_SYNTHASE Citrate synthase signature. GFGHrVy.RaeDPR

Chain	Residue	Details
A	GLY247-ARG259

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10117

Chain	Residue	Details
A	HIS250
A	GLU303
B	HIS250
B	GLU303
C	HIS250
C	GLU303
D	HIS250
D	GLU303
E	HIS250
E	GLU303
F	HIS250
F	GLU303
G	HIS250
G	GLU303
H	HIS250
H	GLU303

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	MOD_RES: N-acetylthreonine => ECO:0007744|PubMed:21969609

Chain	Residue	Details
A	THR2
B	THR2
C	THR2
D	THR2
E	THR2
F	THR2
G	THR2
H	THR2

---