8EM4

Cryo-EM structure of LRP2 at pH 7.5

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005509	molecular_function	calcium ion binding
B	0005509	molecular_function	calcium ion binding

Functional Information from PROSITE/UniProt

site_id	PS00010
Number of Residues	12
Details	ASX_HYDROXYL Aspartic acid and asparagine hydroxylation site. CvNmrgsFrCaC

Chain	Residue	Details
A	CYS1405-CYS1416
A	CYS3128-CYS3139
A	CYS3169-CYS3180
A	CYS4023-CYS4034

---

site_id	PS00022
Number of Residues	12
Details	EGF_1 EGF-like domain signature 1. CkCssGysGEyC

Chain	Residue	Details
A	CYS4401-CYS4412

---

site_id	PS00615
Number of Residues	27
Details	C_TYPE_LECTIN_1 C-type lectin domain signature. CVdidecketpq..LCSQKCenvigsYIC

Chain	Residue	Details
A	CYS3152-CYS3178

---

site_id	PS01186
Number of Residues	15
Details	EGF_2 EGF-like domain signature 2. ClCeeGYilergqh.C

Chain	Residue	Details
A	CYS370-CYS384
A	CYS688-CYS703
A	CYS1374-CYS1389
A	CYS1726-CYS1741
A	CYS2044-CYS2059
A	CYS3137-CYS3152
A	CYS3178-CYS3193
A	CYS4401-CYS4412

---

site_id	PS01187
Number of Residues	24
Details	EGF_CA Calcium-binding EGF-like domain signature. DvNECdipgf.........Csqh....CvNmrgsFrC

Chain	Residue	Details
A	ASP1391-CYS1414
A	ASP3154-CYS3178
A	ASP4009-CYS4032

---

site_id	PS01209
Number of Residues	23
Details	LDLRA_1 LDL-receptor class A (LDLRA) domain signature. CIpaswr.CDgtrDCldd.TDEig...C

Chain	Residue	Details
A	CYS40-CYS62
A	CYS1201-CYS1223
A	CYS1244-CYS1267
A	CYS1284-CYS1306
A	CYS1326-CYS1349
A	CYS2713-CYS2737
A	CYS2754-CYS2776
A	CYS2836-CYS2860
A	CYS2878-CYS2901
A	CYS2920-CYS2945
A	CYS3007-CYS3029
A	CYS80-CYS103
A	CYS3046-CYS3070
A	CYS3089-CYS3111
A	CYS3527-CYS3550
A	CYS3608-CYS3632
A	CYS3649-CYS3673
A	CYS3694-CYS3716
A	CYS3734-CYS3756
A	CYS3773-CYS3795
A	CYS3812-CYS3834
A	CYS3856-CYS3880
A	CYS120-CYS142
A	CYS3898-CYS3922
A	CYS3942-CYS3964
A	CYS195-CYS217
A	CYS234-CYS256
A	CYS1037-CYS1059
A	CYS1079-CYS1101
A	CYS1122-CYS1144
A	CYS1162-CYS1184

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8798
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
A	GLN26-THR4425
B	GLN26-THR4425

---

site_id	SWS_FT_FI2
Number of Residues	40
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
A	MET4426-PHE4446
B	MET4426-PHE4446

---

site_id	SWS_FT_FI3
Number of Residues	426
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
A	PHE4447-VAL4660
B	PHE4447-VAL4660

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P98164

Chain	Residue	Details
A	TRP1127
B	ASP1134
B	ASP1140
B	GLU1141
A	ASP1130
A	ASP1132
A	ASP1134
A	ASP1140
A	GLU1141
B	TRP1127
B	ASP1130
B	ASP1132

---

site_id	SWS_FT_FI5
Number of Residues	12
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P98158

Chain	Residue	Details
A	TYR1206
B	ASP1213
B	ASP1219
B	GLU1220
A	ASP1209
A	VAL1211
A	ASP1213
A	ASP1219
A	GLU1220
B	TYR1206
B	ASP1209
B	VAL1211

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21183079

Chain	Residue	Details
A	SER4464
A	SER4467
A	SER4577
A	SER4658
B	SER4464
B	SER4467
B	SER4577
B	SER4658

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P98158

Chain	Residue	Details
A	SER4624
B	SER4624

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:21183079

Chain	Residue	Details
A	THR4637
B	THR4637

---

site_id	SWS_FT_FI9
Number of Residues	84
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN159
A	ASN1328
A	ASN1341
A	ASN1384
A	ASN1451
A	ASN1497
A	ASN1551
A	ASN1676
A	ASN1733
A	ASN1811
A	ASN2131
A	ASN178
A	ASN2134
A	ASN2178
A	ASN2225
A	ASN2396
A	ASN2488
A	ASN2548
A	ASN2782
A	ASN2810
A	ASN2949
A	ASN2989
A	ASN299
A	ASN3127
A	ASN3213
A	ASN3259
A	ASN3317
A	ASN3357
A	ASN3448
A	ASN3566
A	ASN3682
A	ASN3840
A	ASN3969
A	ASN340
A	ASN3980
A	ASN4070
A	ASN4329
B	ASN159
B	ASN178
B	ASN299
B	ASN340
B	ASN462
B	ASN657
B	ASN865
A	ASN462
B	ASN1063
B	ASN1187
B	ASN1328
B	ASN1341
B	ASN1384
B	ASN1451
B	ASN1497
B	ASN1551
B	ASN1676
B	ASN1733
A	ASN657
B	ASN1811
B	ASN2131
B	ASN2134
B	ASN2178
B	ASN2225
B	ASN2396
B	ASN2488
B	ASN2548
B	ASN2782
B	ASN2810
A	ASN865
B	ASN2949
B	ASN2989
B	ASN3127
B	ASN3213
B	ASN3259
B	ASN3317
B	ASN3357
B	ASN3448
B	ASN3566
B	ASN3682
A	ASN1063
B	ASN3840
B	ASN3969
B	ASN3980
B	ASN4070
B	ASN4329
A	ASN1187

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19349973

Chain	Residue	Details
A	ASN387
B	ASN387

---