8EEV

Venezuelan equine encephalitis virus-like particle in complex with Fab SKT-20

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005198	molecular_function	structural molecule activity
A	0006508	biological_process	proteolysis
A	0008236	molecular_function	serine-type peptidase activity
A	0016020	cellular_component	membrane
A	0019028	cellular_component	viral capsid
A	0019031	cellular_component	viral envelope
A	0019062	biological_process	virion attachment to host cell
A	0020002	cellular_component	host cell plasma membrane
A	0030430	cellular_component	host cell cytoplasm
A	0039619	cellular_component	T=4 icosahedral viral capsid
A	0039654	biological_process	fusion of virus membrane with host endosome membrane
A	0039657	biological_process	symbiont-mediated suppression of host gene expression
A	0039722	biological_process	symbiont-mediated suppression of host toll-like receptor signaling pathway
A	0042025	cellular_component	host cell nucleus
A	0046718	biological_process	symbiont entry into host cell
A	0055036	cellular_component	virion membrane
A	0075512	biological_process	clathrin-dependent endocytosis of virus by host cell
B	0003723	molecular_function	RNA binding
B	0004252	molecular_function	serine-type endopeptidase activity
B	0005198	molecular_function	structural molecule activity
B	0006508	biological_process	proteolysis
B	0008236	molecular_function	serine-type peptidase activity
B	0016020	cellular_component	membrane
B	0019028	cellular_component	viral capsid
B	0019031	cellular_component	viral envelope
B	0019062	biological_process	virion attachment to host cell
B	0020002	cellular_component	host cell plasma membrane
B	0030430	cellular_component	host cell cytoplasm
B	0039619	cellular_component	T=4 icosahedral viral capsid
B	0039654	biological_process	fusion of virus membrane with host endosome membrane
B	0039657	biological_process	symbiont-mediated suppression of host gene expression
B	0039722	biological_process	symbiont-mediated suppression of host toll-like receptor signaling pathway
B	0042025	cellular_component	host cell nucleus
B	0046718	biological_process	symbiont entry into host cell
B	0055036	cellular_component	virion membrane
B	0075512	biological_process	clathrin-dependent endocytosis of virus by host cell
F	0003723	molecular_function	RNA binding
F	0004252	molecular_function	serine-type endopeptidase activity
F	0005198	molecular_function	structural molecule activity
F	0006508	biological_process	proteolysis
F	0008236	molecular_function	serine-type peptidase activity
F	0016020	cellular_component	membrane
F	0019028	cellular_component	viral capsid
F	0019031	cellular_component	viral envelope
F	0019062	biological_process	virion attachment to host cell
F	0020002	cellular_component	host cell plasma membrane
F	0030430	cellular_component	host cell cytoplasm
F	0039619	cellular_component	T=4 icosahedral viral capsid
F	0039654	biological_process	fusion of virus membrane with host endosome membrane
F	0039657	biological_process	symbiont-mediated suppression of host gene expression
F	0039722	biological_process	symbiont-mediated suppression of host toll-like receptor signaling pathway
F	0042025	cellular_component	host cell nucleus
F	0046718	biological_process	symbiont entry into host cell
F	0055036	cellular_component	virion membrane
F	0075512	biological_process	clathrin-dependent endocytosis of virus by host cell
G	0003723	molecular_function	RNA binding
G	0004252	molecular_function	serine-type endopeptidase activity
G	0005198	molecular_function	structural molecule activity
G	0006508	biological_process	proteolysis
G	0008236	molecular_function	serine-type peptidase activity
G	0016020	cellular_component	membrane
G	0019028	cellular_component	viral capsid
G	0019031	cellular_component	viral envelope
G	0019062	biological_process	virion attachment to host cell
G	0020002	cellular_component	host cell plasma membrane
G	0030430	cellular_component	host cell cytoplasm
G	0039619	cellular_component	T=4 icosahedral viral capsid
G	0039654	biological_process	fusion of virus membrane with host endosome membrane
G	0039657	biological_process	symbiont-mediated suppression of host gene expression
G	0039722	biological_process	symbiont-mediated suppression of host toll-like receptor signaling pathway
G	0042025	cellular_component	host cell nucleus
G	0046718	biological_process	symbiont entry into host cell
G	0055036	cellular_component	virion membrane
G	0075512	biological_process	clathrin-dependent endocytosis of virus by host cell
J	0003723	molecular_function	RNA binding
J	0004252	molecular_function	serine-type endopeptidase activity
J	0005198	molecular_function	structural molecule activity
J	0006508	biological_process	proteolysis
J	0008236	molecular_function	serine-type peptidase activity
J	0016020	cellular_component	membrane
J	0019028	cellular_component	viral capsid
J	0019031	cellular_component	viral envelope
J	0019062	biological_process	virion attachment to host cell
J	0020002	cellular_component	host cell plasma membrane
J	0030430	cellular_component	host cell cytoplasm
J	0039619	cellular_component	T=4 icosahedral viral capsid
J	0039654	biological_process	fusion of virus membrane with host endosome membrane
J	0039657	biological_process	symbiont-mediated suppression of host gene expression
J	0039722	biological_process	symbiont-mediated suppression of host toll-like receptor signaling pathway
J	0042025	cellular_component	host cell nucleus
J	0046718	biological_process	symbiont entry into host cell
J	0055036	cellular_component	virion membrane
J	0075512	biological_process	clathrin-dependent endocytosis of virus by host cell
K	0003723	molecular_function	RNA binding
K	0004252	molecular_function	serine-type endopeptidase activity
K	0005198	molecular_function	structural molecule activity
K	0006508	biological_process	proteolysis
K	0008236	molecular_function	serine-type peptidase activity
K	0016020	cellular_component	membrane
K	0019028	cellular_component	viral capsid
K	0019031	cellular_component	viral envelope
K	0019062	biological_process	virion attachment to host cell
K	0020002	cellular_component	host cell plasma membrane
K	0030430	cellular_component	host cell cytoplasm
K	0039619	cellular_component	T=4 icosahedral viral capsid
K	0039654	biological_process	fusion of virus membrane with host endosome membrane
K	0039657	biological_process	symbiont-mediated suppression of host gene expression
K	0039722	biological_process	symbiont-mediated suppression of host toll-like receptor signaling pathway
K	0042025	cellular_component	host cell nucleus
K	0046718	biological_process	symbiont entry into host cell
K	0055036	cellular_component	virion membrane
K	0075512	biological_process	clathrin-dependent endocytosis of virus by host cell

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH

Chain	Residue	Details
H	TYR194-HIS200
L	TYR192-HIS198

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5076
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
A	SER-536-THR-111
A	GLU-54-GLN-40
A	THR5-SER412
B	SER-58-THR367
B	GLU424-GLN438
B	THR483-SER890
F	SER-536-THR-111
F	GLU-54-GLN-40
F	THR5-SER412
G	SER-58-THR367
G	GLU424-GLN438
G	THR483-SER890
J	SER-536-THR-111
J	GLU-54-GLN-40
J	THR5-SER412
K	SER-58-THR367
K	GLU424-GLN438
K	THR483-SER890

---

site_id	SWS_FT_FI2
Number of Residues	480
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
A	ILE-110-LEU-90
A	GLN-39-LEU-19
A	VAL-16-ALA4
A	LEU413-MET433
B	ILE368-LEU388
B	GLN439-LEU459
B	VAL462-ALA482
B	LEU891-MET911
F	ILE-110-LEU-90
F	GLN-39-LEU-19
F	VAL-16-ALA4
F	LEU413-MET433
G	ILE368-LEU388
G	GLN439-LEU459
G	VAL462-ALA482
G	LEU891-MET911
J	ILE-110-LEU-90
J	GLN-39-LEU-19
J	VAL-16-ALA4
J	LEU413-MET433
K	ILE368-LEU388
K	GLN439-LEU459
K	VAL462-ALA482
K	LEU891-MET911

---

site_id	SWS_FT_FI3
Number of Residues	258
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
A	PHE-89-ALA-55
A	ARG-18-CYS-17
A	TYR434-ASN442
B	PHE389-ALA423
B	ARG460-CYS461
B	TYR912-ASN920
F	PHE-89-ALA-55
F	ARG-18-CYS-17
F	TYR434-ASN442
G	PHE389-ALA423
G	ARG460-CYS461
G	TYR912-ASN920
J	PHE-89-ALA-55
J	ARG-18-CYS-17
J	TYR434-ASN442
K	PHE389-ALA423
K	ARG460-CYS461
K	TYR912-ASN920

---

site_id	SWS_FT_FI4
Number of Residues	18
Details	ACT_SITE: Charge relay system => ECO:0000255|PROSITE-ProRule:PRU01027

Chain	Residue	Details
A	HIS-660
A	ASP-638
A	SER-586
B	HIS-182
B	ASP-160
B	SER-108
F	HIS-660
F	ASP-638
F	SER-586
G	HIS-182
G	ASP-160
G	SER-108
J	HIS-660
J	ASP-638
J	SER-586
K	HIS-182
K	ASP-160
K	SER-108

---

site_id	SWS_FT_FI5
Number of Residues	12
Details	SITE: Involved in dimerization of the capsid protein => ECO:0000250|UniProtKB:Q86925

Chain	Residue	Details
A	TYR-612
A	ASN-579
B	TYR-134
B	ASN-101
F	TYR-612
F	ASN-579
G	TYR-134
G	ASN-101
J	TYR-612
J	ASN-579
K	TYR-134
K	ASN-101

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	SITE: Cleavage; by autolysis => ECO:0000250|UniProtKB:P03315

Chain	Residue	Details
A	TRP-537
B	TRP-59
F	TRP-537
G	TRP-59
J	TRP-537
K	TRP-59

---

site_id	SWS_FT_FI7
Number of Residues	12
Details	SITE: Cleavage; by host signal peptidase => ECO:0000250

Chain	Residue	Details
A	ALA-55
A	ALA0
B	ALA423
B	ALA478
F	ALA-55
F	ALA0
G	ALA423
G	ALA478
J	ALA-55
J	ALA0
K	ALA423
K	ALA478

---

site_id	SWS_FT_FI8
Number of Residues	18
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P09592

Chain	Residue	Details
A	THR-719
A	THR-704
A	THR-685
B	THR-241
B	THR-226
B	THR-207
F	THR-719
F	THR-704
F	THR-685
G	THR-241
G	THR-226
G	THR-207
J	THR-719
J	THR-704
J	THR-685
K	THR-241
K	THR-226
K	THR-207

---

site_id	SWS_FT_FI9
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P09592

Chain	Residue	Details
A	SER-688
B	SER-210
F	SER-688
G	SER-210
J	SER-688
K	SER-210

---

site_id	SWS_FT_FI10
Number of Residues	18
Details	LIPID: S-palmitoyl cysteine; by host => ECO:0000250

Chain	Residue	Details
A	CYS-82
A	CYS-62
A	CYS-61
B	CYS396
B	CYS416
B	CYS417
F	CYS-82
F	CYS-62
F	CYS-61
G	CYS396
G	CYS416
G	CYS417
J	CYS-82
J	CYS-62
J	CYS-61
K	CYS396
K	CYS416
K	CYS417

---

site_id	SWS_FT_FI11
Number of Residues	24
Details	CARBOHYD: N-linked (GlcNAc...) asparagine; by host => ECO:0000255

Chain	Residue	Details
A	ASN-526
A	ASN-266
A	ASN-160
A	ASN134
B	ASN-48
B	ASN212
B	ASN318
B	ASN612
F	ASN-526
F	ASN-266
F	ASN-160
F	ASN134
G	ASN-48
G	ASN212
G	ASN318
G	ASN612
J	ASN-526
J	ASN-266
J	ASN-160
J	ASN134
K	ASN-48
K	ASN212
K	ASN318
K	ASN612

---