8DL8
Cryo-EM structure of human ferroportin/slc40 bound to Co2+ in nanodisc
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002260 | biological_process | lymphocyte homeostasis |
| A | 0003158 | biological_process | endothelium development |
| A | 0005381 | molecular_function | iron ion transmembrane transporter activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006366 | biological_process | transcription by RNA polymerase II |
| A | 0006826 | biological_process | iron ion transport |
| A | 0006879 | biological_process | intracellular iron ion homeostasis |
| A | 0006915 | biological_process | apoptotic process |
| A | 0008021 | cellular_component | synaptic vesicle |
| A | 0015093 | molecular_function | ferrous iron transmembrane transporter activity |
| A | 0016020 | cellular_component | membrane |
| A | 0016323 | cellular_component | basolateral plasma membrane |
| A | 0017046 | molecular_function | peptide hormone binding |
| A | 0034755 | biological_process | iron ion transmembrane transport |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0043066 | biological_process | negative regulation of apoptotic process |
| A | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0048536 | biological_process | spleen development |
| A | 0051649 | biological_process | establishment of localization in cell |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0060345 | biological_process | spleen trabecula formation |
| A | 0060586 | biological_process | multicellular organismal-level iron ion homeostasis |
| A | 1903988 | biological_process | iron ion export across plasma membrane |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH |
| Chain | Residue | Details |
| C | TYR212-HIS218 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 134 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:32814342 |
| Chain | Residue | Details |
| A | MET1-SER23 | |
| A | LYS85-ALA87 | |
| A | ALA163-GLY164 | |
| A | THR230-PRO306 | |
| A | CYS367-GLY368 | |
| A | VAL484-GLU488 | |
| A | GLN543-VAL571 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 329 |
| Details | TRANSMEM: Helical => ECO:0000269|PubMed:32814342, ECO:0007744|PDB:6W4S |
| Chain | Residue | Details |
| A | ALA24-LEU53 | |
| A | LEU58-ASP84 | |
| A | ARG88-HIS118 | |
| A | TRP127-VAL162 | |
| A | GLU165-ILE195 | |
| A | ILE203-LYS229 | |
| A | VAL307-TYR333 | |
| A | GLY339-LYS366 | |
| A | LEU369-VAL391 | |
| A | SER454-ASN483 | |
| A | ARG489-LEU513 | |
| A | PRO517-ALA542 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 83 |
| Details | TOPO_DOM: Extracellular => ECO:0000305|PubMed:32814342 |
| Chain | Residue | Details |
| A | TYR54-SER57 | |
| A | GLU119-GLY126 | |
| A | MET196-VAL202 | |
| A | THR334-SER338 | |
| A | PHE392-ILE453 | |
| A | ALA514-ASN516 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:32814342 |
| Chain | Residue | Details |
| A | ASP39 | |
| A | HIS43 | |
| A | CYS326 | |
| A | HIS507 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN434 |
