8D2W
Zebrafish MFSD2A isoform B in inward open ligand 2B conformation
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006869 | biological_process | lipid transport |
| A | 0008643 | biological_process | carbohydrate transport |
| A | 0015245 | molecular_function | fatty acid transmembrane transporter activity |
| A | 0015293 | molecular_function | symporter activity |
| A | 0015908 | biological_process | fatty acid transport |
| A | 0016020 | cellular_component | membrane |
| A | 0045056 | biological_process | transcytosis |
| A | 0051977 | biological_process | lysophospholipid transport |
| A | 0051978 | molecular_function | lysophospholipid:sodium symporter activity |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0060856 | biological_process | establishment of blood-brain barrier |
| A | 0140329 | biological_process | lysophospholipid translocation |
| A | 1990379 | biological_process | lipid transport across blood-brain barrier |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 306 |
| Details | TRANSMEM: Helical => ECO:0000250|UniProtKB:Q9DA75 |
| Chain | Residue | Details |
| A | LEU35-TYR64 | |
| A | SER377-GLN413 | |
| A | PHE424-ALA450 | |
| A | VAL463-PHE486 | |
| A | ALA76-PHE96 | |
| A | MET109-TRP128 | |
| A | VAL139-THR163 | |
| A | LYS171-ALA202 | |
| A | THR227-LEU260 | |
| A | TYR291-ILE317 | |
| A | VAL329-PHE347 | |
| A | GLY352-LEU373 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 65 |
| Details | TOPO_DOM: Extracellular => ECO:0000250|UniProtKB:Q9DA75 |
| Chain | Residue | Details |
| A | LEU65-TYR75 | |
| A | TYR129-VAL138 | |
| A | ASN203-ILE226 | |
| A | TYR318-ASN328 | |
| A | VAL374-SER376 | |
| A | GLY451-GLU462 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 58 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000250|UniProtKB:Q9DA75 |
| Chain | Residue | Details |
| A | LEU97-ARG108 | |
| A | MET164-GLN170 | |
| A | GLY261-PRO290 | |
| A | LEU348-PHE351 | |
| A | ASN414-ILE423 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | GLN214 | |
| A | GLN225 |
