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8C7H

Cryo-EM Map of the latTGF-beta 28G11 Fab complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0005160molecular_functiontransforming growth factor beta receptor binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
B0005576cellular_componentextracellular region
B0008083molecular_functiongrowth factor activity
C0005160molecular_functiontransforming growth factor beta receptor binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
D0005576cellular_componentextracellular region
D0008083molecular_functiongrowth factor activity
I0001818biological_processnegative regulation of cytokine production
I0005515molecular_functionprotein binding
I0005615cellular_componentextracellular space
I0005654cellular_componentnucleoplasm
I0005886cellular_componentplasma membrane
I0007179biological_processtransforming growth factor beta receptor signaling pathway
I0009897cellular_componentexternal side of plasma membrane
I0009986cellular_componentcell surface
I0010628biological_processpositive regulation of gene expression
I0019838molecular_functiongrowth factor binding
I0031012cellular_componentextracellular matrix
I0035592biological_processestablishment of protein localization to extracellular region
I0046007biological_processnegative regulation of activated T cell proliferation
I0050431molecular_functiontransforming growth factor beta binding
I0062009biological_processsecondary palate development
I0141069molecular_functionreceptor ligand inhibitor activity
I1901398biological_processobsolete regulation of transforming growth factor beta3 activation
Functional Information from PROSITE/UniProt
site_idPS00250
Number of Residues16
DetailsTGF_BETA_1 TGF-beta family signature. IhePkgYhanfClGpC
ChainResidueDetails
BILE311-CYS326

site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH
ChainResidueDetails
KTYR212-HIS218
LTYR220-HIS226

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsSITE: Cleavage; by FURIN => ECO:0000269|PubMed:7737999
ChainResidueDetails
IASN345
IASN545
AARG278
CARG278

site_idSWS_FT_FI2
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16263699, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:28117447, ECO:0007744|PDB:5FFO
ChainResidueDetails
CASN82
AASN82

site_idSWS_FT_FI3
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN136
AASN176
CASN136
CASN176

219869

PDB entries from 2024-05-15

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