8AKF
Human Sirt6 in complex with ADP-ribose and fragment 3-aminobenzamide
Functional Information from GO Data
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00236, ECO:0000269|PubMed:18337721, ECO:0000305|PubMed:23552949, ECO:0000305|PubMed:23892288, ECO:0000305|PubMed:27322069, ECO:0000305|PubMed:28406396 |
| Chain | Residue | Details |
| A | HIS133 | |
| B | HIS133 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:21362626, ECO:0007744|PDB:3K35, ECO:0007744|PDB:3ZG6 |
| Chain | Residue | Details |
| A | ALA53 | |
| B | ALA53 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 22 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23552949, ECO:0000305|PubMed:21362626, ECO:0007744|PDB:3K35, ECO:0007744|PDB:3ZG6 |
| Chain | Residue | Details |
| A | THR57 | |
| A | PHE64 | |
| A | ARG65 | |
| A | TRP71 | |
| A | GLN113 | |
| A | HIS133 | |
| A | GLY214 | |
| A | SER216 | |
| A | ASN240 | |
| A | GLN242 | |
| A | VAL258 | |
| B | THR57 | |
| B | PHE64 | |
| B | ARG65 | |
| B | TRP71 | |
| B | GLN113 | |
| B | HIS133 | |
| B | GLY214 | |
| B | SER216 | |
| B | ASN240 | |
| B | GLN242 | |
| B | VAL258 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00236, ECO:0000269|PubMed:21362626, ECO:0000269|PubMed:23552949, ECO:0000269|PubMed:27990725, ECO:0007744|PDB:3K35, ECO:0007744|PDB:3PKI, ECO:0007744|PDB:3PKJ, ECO:0007744|PDB:3ZG6, ECO:0007744|PDB:5MF6, ECO:0007744|PDB:5MFP, ECO:0007744|PDB:5MFZ, ECO:0007744|PDB:5MGN |
| Chain | Residue | Details |
| A | CYS141 | |
| A | CYS144 | |
| A | CYS166 | |
| A | CYS177 | |
| B | CYS141 | |
| B | CYS144 | |
| B | CYS166 | |
| B | CYS177 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | SITE: Formation of an covalent adduct with nitro-fatty acid activators => ECO:0000269|PubMed:33122195 |
| Chain | Residue | Details |
| A | CYS18 | |
| B | CYS18 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:32538779 |
| Chain | Residue | Details |
| A | LYS33 | |
| B | LYS33 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | THR294 | |
| B | THR294 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER303 | |
| B | SER303 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:24043303 |
| Chain | Residue | Details |
| A | LYS170 | |
| B | LYS170 |
