7ZH9
Uba1 in complex with ATP
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004839 | molecular_function | ubiquitin activating enzyme activity |
A | 0005524 | molecular_function | ATP binding |
A | 0005634 | cellular_component | nucleus |
A | 0005737 | cellular_component | cytoplasm |
A | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
A | 0006974 | biological_process | DNA damage response |
A | 0008641 | molecular_function | ubiquitin-like modifier activating enzyme activity |
A | 0016567 | biological_process | protein ubiquitination |
A | 0016874 | molecular_function | ligase activity |
A | 0036211 | biological_process | protein modification process |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: Glycyl thioester intermediate => ECO:0000255|PROSITE-ProRule:PRU10132, ECO:0000269|PubMed:24816100 |
Chain | Residue | Details |
A | CYS600 |
site_id | SWS_FT_FI2 |
Number of Residues | 5 |
Details | BINDING: BINDING => ECO:0000305|PubMed:24816100 |
Chain | Residue | Details |
A | ALA444 | |
A | ASP470 | |
A | ARG481 | |
A | LYS494 | |
A | ASP544 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | MOD_RES: N-acetylserine => ECO:0007744|PubMed:22814378 |
Chain | Residue | Details |
A | SER2 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17287358 |
Chain | Residue | Details |
A | SER265 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956 |
Chain | Residue | Details |
A | SER914 |
site_id | SWS_FT_FI6 |
Number of Residues | 3 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047 |
Chain | Residue | Details |
A | LYS595 | |
A | LYS608 |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 8 |
Details | M-CSA 307 |
Chain | Residue | Details |
A | ARG21 | electrostatic stabiliser, hydrogen bond donor, steric role |
A | ARG481 | electrostatic stabiliser, hydrogen bond donor, steric role |
A | ASP544 | steric role |
A | CYS600 | activator, covalently attached, hydrogen bond donor, nucleophile, proton donor |
A | THR601 | hydrogen bond acceptor, hydrogen bond donor, increase acidity, increase nucleophilicity, proton acceptor, proton donor, proton relay |
A | ARG603 | electrostatic stabiliser, hydrogen bond donor |
A | ASN781 | electrostatic stabiliser, hydrogen bond donor |
A | ASP782 | electrostatic stabiliser, hydrogen bond donor |
site_id | MCSA2 |
Number of Residues | 5 |
Details | M-CSA 939 |
Chain | Residue | Details |
A | CYS600 | nucleofuge |
A | THR601 | modifies pKa |
A | ARG603 | electrostatic stabiliser |
A | ASN781 | electrostatic stabiliser |
A | ASP782 | electrostatic stabiliser |