7UTJ

Cryogenic electron microscopy 3D map of F-actin bound by human dimeric alpha-catenin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0001725	cellular_component	stress fiber
A	0003785	molecular_function	actin monomer binding
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005523	molecular_function	tropomyosin binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005856	cellular_component	cytoskeleton
A	0005865	cellular_component	striated muscle thin filament
A	0005884	cellular_component	actin filament
A	0010628	biological_process	positive regulation of gene expression
A	0016787	molecular_function	hydrolase activity
A	0019904	molecular_function	protein domain specific binding
A	0030027	cellular_component	lamellipodium
A	0030041	biological_process	actin filament polymerization
A	0030175	cellular_component	filopodium
A	0030240	biological_process	skeletal muscle thin filament assembly
A	0031013	molecular_function	troponin I binding
A	0031432	molecular_function	titin binding
A	0031941	cellular_component	filamentous actin
A	0032036	molecular_function	myosin heavy chain binding
A	0032432	cellular_component	actin filament bundle
A	0042802	molecular_function	identical protein binding
A	0044297	cellular_component	cell body
A	0048306	molecular_function	calcium-dependent protein binding
A	0048741	biological_process	skeletal muscle fiber development
A	0051017	biological_process	actin filament bundle assembly
A	0090131	biological_process	mesenchyme migration
A	0098723	cellular_component	skeletal muscle myofibril
A	0140660	molecular_function	cytoskeletal motor activator activity
B	0000287	molecular_function	magnesium ion binding
B	0001725	cellular_component	stress fiber
B	0003785	molecular_function	actin monomer binding
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005523	molecular_function	tropomyosin binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005856	cellular_component	cytoskeleton
B	0005865	cellular_component	striated muscle thin filament
B	0005884	cellular_component	actin filament
B	0010628	biological_process	positive regulation of gene expression
B	0016787	molecular_function	hydrolase activity
B	0019904	molecular_function	protein domain specific binding
B	0030027	cellular_component	lamellipodium
B	0030041	biological_process	actin filament polymerization
B	0030175	cellular_component	filopodium
B	0030240	biological_process	skeletal muscle thin filament assembly
B	0031013	molecular_function	troponin I binding
B	0031432	molecular_function	titin binding
B	0031941	cellular_component	filamentous actin
B	0032036	molecular_function	myosin heavy chain binding
B	0032432	cellular_component	actin filament bundle
B	0042802	molecular_function	identical protein binding
B	0044297	cellular_component	cell body
B	0048306	molecular_function	calcium-dependent protein binding
B	0048741	biological_process	skeletal muscle fiber development
B	0051017	biological_process	actin filament bundle assembly
B	0090131	biological_process	mesenchyme migration
B	0098723	cellular_component	skeletal muscle myofibril
B	0140660	molecular_function	cytoskeletal motor activator activity
C	0000287	molecular_function	magnesium ion binding
C	0001725	cellular_component	stress fiber
C	0003785	molecular_function	actin monomer binding
C	0005509	molecular_function	calcium ion binding
C	0005515	molecular_function	protein binding
C	0005523	molecular_function	tropomyosin binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005856	cellular_component	cytoskeleton
C	0005865	cellular_component	striated muscle thin filament
C	0005884	cellular_component	actin filament
C	0010628	biological_process	positive regulation of gene expression
C	0016787	molecular_function	hydrolase activity
C	0019904	molecular_function	protein domain specific binding
C	0030027	cellular_component	lamellipodium
C	0030041	biological_process	actin filament polymerization
C	0030175	cellular_component	filopodium
C	0030240	biological_process	skeletal muscle thin filament assembly
C	0031013	molecular_function	troponin I binding
C	0031432	molecular_function	titin binding
C	0031941	cellular_component	filamentous actin
C	0032036	molecular_function	myosin heavy chain binding
C	0032432	cellular_component	actin filament bundle
C	0042802	molecular_function	identical protein binding
C	0044297	cellular_component	cell body
C	0048306	molecular_function	calcium-dependent protein binding
C	0048741	biological_process	skeletal muscle fiber development
C	0051017	biological_process	actin filament bundle assembly
C	0090131	biological_process	mesenchyme migration
C	0098723	cellular_component	skeletal muscle myofibril
C	0140660	molecular_function	cytoskeletal motor activator activity
D	0000287	molecular_function	magnesium ion binding
D	0001725	cellular_component	stress fiber
D	0003785	molecular_function	actin monomer binding
D	0005509	molecular_function	calcium ion binding
D	0005515	molecular_function	protein binding
D	0005523	molecular_function	tropomyosin binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005856	cellular_component	cytoskeleton
D	0005865	cellular_component	striated muscle thin filament
D	0005884	cellular_component	actin filament
D	0010628	biological_process	positive regulation of gene expression
D	0016787	molecular_function	hydrolase activity
D	0019904	molecular_function	protein domain specific binding
D	0030027	cellular_component	lamellipodium
D	0030041	biological_process	actin filament polymerization
D	0030175	cellular_component	filopodium
D	0030240	biological_process	skeletal muscle thin filament assembly
D	0031013	molecular_function	troponin I binding
D	0031432	molecular_function	titin binding
D	0031941	cellular_component	filamentous actin
D	0032036	molecular_function	myosin heavy chain binding
D	0032432	cellular_component	actin filament bundle
D	0042802	molecular_function	identical protein binding
D	0044297	cellular_component	cell body
D	0048306	molecular_function	calcium-dependent protein binding
D	0048741	biological_process	skeletal muscle fiber development
D	0051017	biological_process	actin filament bundle assembly
D	0090131	biological_process	mesenchyme migration
D	0098723	cellular_component	skeletal muscle myofibril
D	0140660	molecular_function	cytoskeletal motor activator activity
E	0000287	molecular_function	magnesium ion binding
E	0001725	cellular_component	stress fiber
E	0003785	molecular_function	actin monomer binding
E	0005509	molecular_function	calcium ion binding
E	0005515	molecular_function	protein binding
E	0005523	molecular_function	tropomyosin binding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005856	cellular_component	cytoskeleton
E	0005865	cellular_component	striated muscle thin filament
E	0005884	cellular_component	actin filament
E	0010628	biological_process	positive regulation of gene expression
E	0016787	molecular_function	hydrolase activity
E	0019904	molecular_function	protein domain specific binding
E	0030027	cellular_component	lamellipodium
E	0030041	biological_process	actin filament polymerization
E	0030175	cellular_component	filopodium
E	0030240	biological_process	skeletal muscle thin filament assembly
E	0031013	molecular_function	troponin I binding
E	0031432	molecular_function	titin binding
E	0031941	cellular_component	filamentous actin
E	0032036	molecular_function	myosin heavy chain binding
E	0032432	cellular_component	actin filament bundle
E	0042802	molecular_function	identical protein binding
E	0044297	cellular_component	cell body
E	0048306	molecular_function	calcium-dependent protein binding
E	0048741	biological_process	skeletal muscle fiber development
E	0051017	biological_process	actin filament bundle assembly
E	0090131	biological_process	mesenchyme migration
E	0098723	cellular_component	skeletal muscle myofibril
E	0140660	molecular_function	cytoskeletal motor activator activity
F	0000287	molecular_function	magnesium ion binding
F	0001725	cellular_component	stress fiber
F	0003785	molecular_function	actin monomer binding
F	0005509	molecular_function	calcium ion binding
F	0005515	molecular_function	protein binding
F	0005523	molecular_function	tropomyosin binding
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005856	cellular_component	cytoskeleton
F	0005865	cellular_component	striated muscle thin filament
F	0005884	cellular_component	actin filament
F	0010628	biological_process	positive regulation of gene expression
F	0016787	molecular_function	hydrolase activity
F	0019904	molecular_function	protein domain specific binding
F	0030027	cellular_component	lamellipodium
F	0030041	biological_process	actin filament polymerization
F	0030175	cellular_component	filopodium
F	0030240	biological_process	skeletal muscle thin filament assembly
F	0031013	molecular_function	troponin I binding
F	0031432	molecular_function	titin binding
F	0031941	cellular_component	filamentous actin
F	0032036	molecular_function	myosin heavy chain binding
F	0032432	cellular_component	actin filament bundle
F	0042802	molecular_function	identical protein binding
F	0044297	cellular_component	cell body
F	0048306	molecular_function	calcium-dependent protein binding
F	0048741	biological_process	skeletal muscle fiber development
F	0051017	biological_process	actin filament bundle assembly
F	0090131	biological_process	mesenchyme migration
F	0098723	cellular_component	skeletal muscle myofibril
F	0140660	molecular_function	cytoskeletal motor activator activity
G	0001541	biological_process	ovarian follicle development
G	0001669	cellular_component	acrosomal vesicle
G	0003723	molecular_function	RNA binding
G	0005198	molecular_function	structural molecule activity
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005856	cellular_component	cytoskeleton
G	0005886	cellular_component	plasma membrane
G	0005911	cellular_component	cell-cell junction
G	0005912	cellular_component	adherens junction
G	0005915	cellular_component	zonula adherens
G	0005925	cellular_component	focal adhesion
G	0006915	biological_process	apoptotic process
G	0007155	biological_process	cell adhesion
G	0007163	biological_process	establishment or maintenance of cell polarity
G	0007224	biological_process	smoothened signaling pathway
G	0007229	biological_process	integrin-mediated signaling pathway
G	0007405	biological_process	neuroblast proliferation
G	0007406	biological_process	negative regulation of neuroblast proliferation
G	0008013	molecular_function	beta-catenin binding
G	0008104	biological_process	protein localization
G	0008584	biological_process	male gonad development
G	0014070	biological_process	response to organic cyclic compound
G	0014704	cellular_component	intercalated disc
G	0015629	cellular_component	actin cytoskeleton
G	0016264	biological_process	gap junction assembly
G	0016342	cellular_component	catenin complex
G	0016477	biological_process	cell migration
G	0016600	cellular_component	flotillin complex
G	0017166	molecular_function	vinculin binding
G	0030027	cellular_component	lamellipodium
G	0030054	cellular_component	cell junction
G	0031103	biological_process	axon regeneration
G	0042127	biological_process	regulation of cell population proliferation
G	0042475	biological_process	odontogenesis of dentin-containing tooth
G	0042802	molecular_function	identical protein binding
G	0043066	biological_process	negative regulation of apoptotic process
G	0043231	cellular_component	intracellular membrane-bounded organelle
G	0043297	biological_process	apical junction assembly
G	0043627	biological_process	response to estrogen
G	0044877	molecular_function	protein-containing complex binding
G	0045295	molecular_function	gamma-catenin binding
G	0045296	molecular_function	cadherin binding
G	0045880	biological_process	positive regulation of smoothened signaling pathway
G	0048870	biological_process	cell motility
G	0051015	molecular_function	actin filament binding
G	0070161	cellular_component	anchoring junction
G	0071681	biological_process	cellular response to indole-3-methanol
G	0090136	biological_process	epithelial cell-cell adhesion
G	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
G	0098609	biological_process	cell-cell adhesion
G	1900181	biological_process	negative regulation of protein localization to nucleus
G	2000146	biological_process	negative regulation of cell motility
G	2001045	biological_process	negative regulation of integrin-mediated signaling pathway
G	2001240	biological_process	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
G	2001241	biological_process	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
H	0001541	biological_process	ovarian follicle development
H	0001669	cellular_component	acrosomal vesicle
H	0003723	molecular_function	RNA binding
H	0005198	molecular_function	structural molecule activity
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005856	cellular_component	cytoskeleton
H	0005886	cellular_component	plasma membrane
H	0005911	cellular_component	cell-cell junction
H	0005912	cellular_component	adherens junction
H	0005915	cellular_component	zonula adherens
H	0005925	cellular_component	focal adhesion
H	0006915	biological_process	apoptotic process
H	0007155	biological_process	cell adhesion
H	0007163	biological_process	establishment or maintenance of cell polarity
H	0007224	biological_process	smoothened signaling pathway
H	0007229	biological_process	integrin-mediated signaling pathway
H	0007405	biological_process	neuroblast proliferation
H	0007406	biological_process	negative regulation of neuroblast proliferation
H	0008013	molecular_function	beta-catenin binding
H	0008104	biological_process	protein localization
H	0008584	biological_process	male gonad development
H	0014070	biological_process	response to organic cyclic compound
H	0014704	cellular_component	intercalated disc
H	0015629	cellular_component	actin cytoskeleton
H	0016264	biological_process	gap junction assembly
H	0016342	cellular_component	catenin complex
H	0016477	biological_process	cell migration
H	0016600	cellular_component	flotillin complex
H	0017166	molecular_function	vinculin binding
H	0030027	cellular_component	lamellipodium
H	0030054	cellular_component	cell junction
H	0031103	biological_process	axon regeneration
H	0042127	biological_process	regulation of cell population proliferation
H	0042475	biological_process	odontogenesis of dentin-containing tooth
H	0042802	molecular_function	identical protein binding
H	0043066	biological_process	negative regulation of apoptotic process
H	0043231	cellular_component	intracellular membrane-bounded organelle
H	0043297	biological_process	apical junction assembly
H	0043627	biological_process	response to estrogen
H	0044877	molecular_function	protein-containing complex binding
H	0045295	molecular_function	gamma-catenin binding
H	0045296	molecular_function	cadherin binding
H	0045880	biological_process	positive regulation of smoothened signaling pathway
H	0048870	biological_process	cell motility
H	0051015	molecular_function	actin filament binding
H	0070161	cellular_component	anchoring junction
H	0071681	biological_process	cellular response to indole-3-methanol
H	0090136	biological_process	epithelial cell-cell adhesion
H	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
H	0098609	biological_process	cell-cell adhesion
H	1900181	biological_process	negative regulation of protein localization to nucleus
H	2000146	biological_process	negative regulation of cell motility
H	2001045	biological_process	negative regulation of integrin-mediated signaling pathway
H	2001240	biological_process	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
H	2001241	biological_process	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
I	0001541	biological_process	ovarian follicle development
I	0001669	cellular_component	acrosomal vesicle
I	0003723	molecular_function	RNA binding
I	0005198	molecular_function	structural molecule activity
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0005856	cellular_component	cytoskeleton
I	0005886	cellular_component	plasma membrane
I	0005911	cellular_component	cell-cell junction
I	0005912	cellular_component	adherens junction
I	0005915	cellular_component	zonula adherens
I	0005925	cellular_component	focal adhesion
I	0006915	biological_process	apoptotic process
I	0007155	biological_process	cell adhesion
I	0007163	biological_process	establishment or maintenance of cell polarity
I	0007224	biological_process	smoothened signaling pathway
I	0007229	biological_process	integrin-mediated signaling pathway
I	0007405	biological_process	neuroblast proliferation
I	0007406	biological_process	negative regulation of neuroblast proliferation
I	0008013	molecular_function	beta-catenin binding
I	0008104	biological_process	protein localization
I	0008584	biological_process	male gonad development
I	0014070	biological_process	response to organic cyclic compound
I	0014704	cellular_component	intercalated disc
I	0015629	cellular_component	actin cytoskeleton
I	0016264	biological_process	gap junction assembly
I	0016342	cellular_component	catenin complex
I	0016477	biological_process	cell migration
I	0016600	cellular_component	flotillin complex
I	0017166	molecular_function	vinculin binding
I	0030027	cellular_component	lamellipodium
I	0030054	cellular_component	cell junction
I	0031103	biological_process	axon regeneration
I	0042127	biological_process	regulation of cell population proliferation
I	0042475	biological_process	odontogenesis of dentin-containing tooth
I	0042802	molecular_function	identical protein binding
I	0043066	biological_process	negative regulation of apoptotic process
I	0043231	cellular_component	intracellular membrane-bounded organelle
I	0043297	biological_process	apical junction assembly
I	0043627	biological_process	response to estrogen
I	0044877	molecular_function	protein-containing complex binding
I	0045295	molecular_function	gamma-catenin binding
I	0045296	molecular_function	cadherin binding
I	0045880	biological_process	positive regulation of smoothened signaling pathway
I	0048870	biological_process	cell motility
I	0051015	molecular_function	actin filament binding
I	0070161	cellular_component	anchoring junction
I	0071681	biological_process	cellular response to indole-3-methanol
I	0090136	biological_process	epithelial cell-cell adhesion
I	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
I	0098609	biological_process	cell-cell adhesion
I	1900181	biological_process	negative regulation of protein localization to nucleus
I	2000146	biological_process	negative regulation of cell motility
I	2001045	biological_process	negative regulation of integrin-mediated signaling pathway
I	2001240	biological_process	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
I	2001241	biological_process	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
K	0001541	biological_process	ovarian follicle development
K	0001669	cellular_component	acrosomal vesicle
K	0003723	molecular_function	RNA binding
K	0005198	molecular_function	structural molecule activity
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0005856	cellular_component	cytoskeleton
K	0005886	cellular_component	plasma membrane
K	0005911	cellular_component	cell-cell junction
K	0005912	cellular_component	adherens junction
K	0005915	cellular_component	zonula adherens
K	0005925	cellular_component	focal adhesion
K	0006915	biological_process	apoptotic process
K	0007155	biological_process	cell adhesion
K	0007163	biological_process	establishment or maintenance of cell polarity
K	0007224	biological_process	smoothened signaling pathway
K	0007229	biological_process	integrin-mediated signaling pathway
K	0007405	biological_process	neuroblast proliferation
K	0007406	biological_process	negative regulation of neuroblast proliferation
K	0008013	molecular_function	beta-catenin binding
K	0008104	biological_process	protein localization
K	0008584	biological_process	male gonad development
K	0014070	biological_process	response to organic cyclic compound
K	0014704	cellular_component	intercalated disc
K	0015629	cellular_component	actin cytoskeleton
K	0016264	biological_process	gap junction assembly
K	0016342	cellular_component	catenin complex
K	0016477	biological_process	cell migration
K	0016600	cellular_component	flotillin complex
K	0017166	molecular_function	vinculin binding
K	0030027	cellular_component	lamellipodium
K	0030054	cellular_component	cell junction
K	0031103	biological_process	axon regeneration
K	0042127	biological_process	regulation of cell population proliferation
K	0042475	biological_process	odontogenesis of dentin-containing tooth
K	0042802	molecular_function	identical protein binding
K	0043066	biological_process	negative regulation of apoptotic process
K	0043231	cellular_component	intracellular membrane-bounded organelle
K	0043297	biological_process	apical junction assembly
K	0043627	biological_process	response to estrogen
K	0044877	molecular_function	protein-containing complex binding
K	0045295	molecular_function	gamma-catenin binding
K	0045296	molecular_function	cadherin binding
K	0045880	biological_process	positive regulation of smoothened signaling pathway
K	0048870	biological_process	cell motility
K	0051015	molecular_function	actin filament binding
K	0070161	cellular_component	anchoring junction
K	0071681	biological_process	cellular response to indole-3-methanol
K	0090136	biological_process	epithelial cell-cell adhesion
K	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
K	0098609	biological_process	cell-cell adhesion
K	1900181	biological_process	negative regulation of protein localization to nucleus
K	2000146	biological_process	negative regulation of cell motility
K	2001045	biological_process	negative regulation of integrin-mediated signaling pathway
K	2001240	biological_process	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
K	2001241	biological_process	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
L	0001541	biological_process	ovarian follicle development
L	0001669	cellular_component	acrosomal vesicle
L	0003723	molecular_function	RNA binding
L	0005198	molecular_function	structural molecule activity
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0005856	cellular_component	cytoskeleton
L	0005886	cellular_component	plasma membrane
L	0005911	cellular_component	cell-cell junction
L	0005912	cellular_component	adherens junction
L	0005915	cellular_component	zonula adherens
L	0005925	cellular_component	focal adhesion
L	0006915	biological_process	apoptotic process
L	0007155	biological_process	cell adhesion
L	0007163	biological_process	establishment or maintenance of cell polarity
L	0007224	biological_process	smoothened signaling pathway
L	0007229	biological_process	integrin-mediated signaling pathway
L	0007405	biological_process	neuroblast proliferation
L	0007406	biological_process	negative regulation of neuroblast proliferation
L	0008013	molecular_function	beta-catenin binding
L	0008104	biological_process	protein localization
L	0008584	biological_process	male gonad development
L	0014070	biological_process	response to organic cyclic compound
L	0014704	cellular_component	intercalated disc
L	0015629	cellular_component	actin cytoskeleton
L	0016264	biological_process	gap junction assembly
L	0016342	cellular_component	catenin complex
L	0016477	biological_process	cell migration
L	0016600	cellular_component	flotillin complex
L	0017166	molecular_function	vinculin binding
L	0030027	cellular_component	lamellipodium
L	0030054	cellular_component	cell junction
L	0031103	biological_process	axon regeneration
L	0042127	biological_process	regulation of cell population proliferation
L	0042475	biological_process	odontogenesis of dentin-containing tooth
L	0042802	molecular_function	identical protein binding
L	0043066	biological_process	negative regulation of apoptotic process
L	0043231	cellular_component	intracellular membrane-bounded organelle
L	0043297	biological_process	apical junction assembly
L	0043627	biological_process	response to estrogen
L	0044877	molecular_function	protein-containing complex binding
L	0045295	molecular_function	gamma-catenin binding
L	0045296	molecular_function	cadherin binding
L	0045880	biological_process	positive regulation of smoothened signaling pathway
L	0048870	biological_process	cell motility
L	0051015	molecular_function	actin filament binding
L	0070161	cellular_component	anchoring junction
L	0071681	biological_process	cellular response to indole-3-methanol
L	0090136	biological_process	epithelial cell-cell adhesion
L	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
L	0098609	biological_process	cell-cell adhesion
L	1900181	biological_process	negative regulation of protein localization to nucleus
L	2000146	biological_process	negative regulation of cell motility
L	2001045	biological_process	negative regulation of integrin-mediated signaling pathway
L	2001240	biological_process	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
L	2001241	biological_process	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
Z	0001541	biological_process	ovarian follicle development
Z	0001669	cellular_component	acrosomal vesicle
Z	0003723	molecular_function	RNA binding
Z	0005198	molecular_function	structural molecule activity
Z	0005515	molecular_function	protein binding
Z	0005634	cellular_component	nucleus
Z	0005737	cellular_component	cytoplasm
Z	0005829	cellular_component	cytosol
Z	0005856	cellular_component	cytoskeleton
Z	0005886	cellular_component	plasma membrane
Z	0005911	cellular_component	cell-cell junction
Z	0005912	cellular_component	adherens junction
Z	0005915	cellular_component	zonula adherens
Z	0005925	cellular_component	focal adhesion
Z	0006915	biological_process	apoptotic process
Z	0007155	biological_process	cell adhesion
Z	0007163	biological_process	establishment or maintenance of cell polarity
Z	0007224	biological_process	smoothened signaling pathway
Z	0007229	biological_process	integrin-mediated signaling pathway
Z	0007405	biological_process	neuroblast proliferation
Z	0007406	biological_process	negative regulation of neuroblast proliferation
Z	0008013	molecular_function	beta-catenin binding
Z	0008104	biological_process	protein localization
Z	0008584	biological_process	male gonad development
Z	0014070	biological_process	response to organic cyclic compound
Z	0014704	cellular_component	intercalated disc
Z	0015629	cellular_component	actin cytoskeleton
Z	0016264	biological_process	gap junction assembly
Z	0016342	cellular_component	catenin complex
Z	0016477	biological_process	cell migration
Z	0016600	cellular_component	flotillin complex
Z	0017166	molecular_function	vinculin binding
Z	0030027	cellular_component	lamellipodium
Z	0030054	cellular_component	cell junction
Z	0031103	biological_process	axon regeneration
Z	0042127	biological_process	regulation of cell population proliferation
Z	0042475	biological_process	odontogenesis of dentin-containing tooth
Z	0042802	molecular_function	identical protein binding
Z	0043066	biological_process	negative regulation of apoptotic process
Z	0043231	cellular_component	intracellular membrane-bounded organelle
Z	0043297	biological_process	apical junction assembly
Z	0043627	biological_process	response to estrogen
Z	0044877	molecular_function	protein-containing complex binding
Z	0045295	molecular_function	gamma-catenin binding
Z	0045296	molecular_function	cadherin binding
Z	0045880	biological_process	positive regulation of smoothened signaling pathway
Z	0048870	biological_process	cell motility
Z	0051015	molecular_function	actin filament binding
Z	0070161	cellular_component	anchoring junction
Z	0071681	biological_process	cellular response to indole-3-methanol
Z	0090136	biological_process	epithelial cell-cell adhesion
Z	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
Z	0098609	biological_process	cell-cell adhesion
Z	1900181	biological_process	negative regulation of protein localization to nucleus
Z	2000146	biological_process	negative regulation of cell motility
Z	2001045	biological_process	negative regulation of integrin-mediated signaling pathway
Z	2001240	biological_process	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Z	2001241	biological_process	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

Functional Information from PROSITE/UniProt

site_id	PS00406
Number of Residues	11
Details	ACTINS_1 Actins signature 1. YVGDEAQs.KRG

Chain	Residue	Details
A	TYR53-GLY63

---

site_id	PS00432
Number of Residues	9
Details	ACTINS_2 Actins signature 2. WITKqEYDE

Chain	Residue	Details
A	TRP356-GLU364

---

site_id	PS01132
Number of Residues	13
Details	ACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR

Chain	Residue	Details
A	LEU104-ARG116

---

site_id	PS00663
Number of Residues	21
Details	VINCULIN_1 Vinculin family talin-binding region signature. KaLkpeVdkLnimaakRQQEL

Chain	Residue	Details
G	LYS178-LEU198

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	30
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
H	SER268
H	SER295
H	SER297
H	SER851
I	SER264
I	SER268
I	SER295
I	SER297
I	SER851
K	SER264
K	SER268
K	SER295
K	SER297
K	SER851
L	SER264
L	SER268
L	SER295
L	SER297
L	SER851
Z	SER264
Z	SER268
Z	SER295
Z	SER297
Z	SER851
G	SER268
G	SER851
G	SER264
G	SER295
G	SER297
H	SER264

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:24275569

Chain	Residue	Details
H	THR634
G	THR634
L	THR634
I	THR634
K	THR634
Z	THR634

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	MOD_RES: Phosphoserine; by CK2 => ECO:0000269|PubMed:25653389, ECO:0007744|PubMed:16807684, ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:18318008, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
D	MET44
D	MET47
E	MET44
E	MET47
F	MET44
F	MET47
H	SER641
L	SER641
Z	SER641
G	SER641
I	SER641
K	SER641

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18318008

Chain	Residue	Details
L	THR645
H	THR645
Z	THR645
G	THR645
I	THR645
K	THR645

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	MOD_RES: Phosphoserine; by CK1 => ECO:0000269|PubMed:25653389, ECO:0007744|PubMed:17487921, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:21406692

Chain	Residue	Details
L	SER652
H	SER652
G	SER652
I	SER652
K	SER652
Z	SER652

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	MOD_RES: Phosphoserine; by CK1 => ECO:0000269|PubMed:25653389

Chain	Residue	Details
K	SER655
L	SER655
G	SER655
H	SER655
I	SER655
Z	SER655

---

site_id	SWS_FT_FI7
Number of Residues	6
Details	MOD_RES: Phosphothreonine; by CK1 => ECO:0000269|PubMed:25653389

Chain	Residue	Details
K	THR658
G	THR658
H	THR658
I	THR658
L	THR658
Z	THR658

---

site_id	SWS_FT_FI8
Number of Residues	18
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
G	LYS57
G	LYS797
H	LYS57
H	LYS797
I	LYS57
I	LYS797
K	LYS57
K	LYS797
L	LYS57
L	LYS797
Z	LYS57
Z	LYS797

---