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7SJ9

13pf E254A microtubule from recombinant human tubulin decorated with EB3

Functional Information from GO Data
ChainGOidnamespacecontents
A0000226biological_processmicrotubule cytoskeleton organization
A0000278biological_processmitotic cell cycle
A0003725molecular_functiondouble-stranded RNA binding
A0003924molecular_functionGTPase activity
A0005198molecular_functionstructural molecule activity
A0005200molecular_functionstructural constituent of cytoskeleton
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005737cellular_componentcytoplasm
A0005856cellular_componentcytoskeleton
A0005874cellular_componentmicrotubule
A0005881cellular_componentcytoplasmic microtubule
A0007017biological_processmicrotubule-based process
A0015630cellular_componentmicrotubule cytoskeleton
A0016787molecular_functionhydrolase activity
A0030705biological_processcytoskeleton-dependent intracellular transport
A0031625molecular_functionubiquitin protein ligase binding
A0051301biological_processcell division
A0071353biological_processcellular response to interleukin-4
B0000226biological_processmicrotubule cytoskeleton organization
B0000278biological_processmitotic cell cycle
B0003924molecular_functionGTPase activity
B0005200molecular_functionstructural constituent of cytoskeleton
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005856cellular_componentcytoskeleton
B0005874cellular_componentmicrotubule
B0007017biological_processmicrotubule-based process
B0007411biological_processaxon guidance
B0015630cellular_componentmicrotubule cytoskeleton
B0030027cellular_componentlamellipodium
B0030175cellular_componentfilopodium
B0030182biological_processneuron differentiation
B0030424cellular_componentaxon
B0030425cellular_componentdendrite
B0030426cellular_componentgrowth cone
B0038007biological_processnetrin-activated signaling pathway
B0042277molecular_functionpeptide binding
B0042995cellular_componentcell projection
B0043025cellular_componentneuronal cell body
B0045171cellular_componentintercellular bridge
B0046872molecular_functionmetal ion binding
B0070062cellular_componentextracellular exosome
B0071944cellular_componentcell periphery
B0072686cellular_componentmitotic spindle
B1990791biological_processdorsal root ganglion development
B1990890molecular_functionnetrin receptor binding
C0000226biological_processmicrotubule cytoskeleton organization
C0000278biological_processmitotic cell cycle
C0003725molecular_functiondouble-stranded RNA binding
C0003924molecular_functionGTPase activity
C0005198molecular_functionstructural molecule activity
C0005200molecular_functionstructural constituent of cytoskeleton
C0005515molecular_functionprotein binding
C0005525molecular_functionGTP binding
C0005737cellular_componentcytoplasm
C0005856cellular_componentcytoskeleton
C0005874cellular_componentmicrotubule
C0005881cellular_componentcytoplasmic microtubule
C0007017biological_processmicrotubule-based process
C0015630cellular_componentmicrotubule cytoskeleton
C0016787molecular_functionhydrolase activity
C0030705biological_processcytoskeleton-dependent intracellular transport
C0031625molecular_functionubiquitin protein ligase binding
C0051301biological_processcell division
C0071353biological_processcellular response to interleukin-4
D0000226biological_processmicrotubule cytoskeleton organization
D0000278biological_processmitotic cell cycle
D0003924molecular_functionGTPase activity
D0005200molecular_functionstructural constituent of cytoskeleton
D0005515molecular_functionprotein binding
D0005525molecular_functionGTP binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005856cellular_componentcytoskeleton
D0005874cellular_componentmicrotubule
D0007017biological_processmicrotubule-based process
D0007411biological_processaxon guidance
D0015630cellular_componentmicrotubule cytoskeleton
D0030027cellular_componentlamellipodium
D0030175cellular_componentfilopodium
D0030182biological_processneuron differentiation
D0030424cellular_componentaxon
D0030425cellular_componentdendrite
D0030426cellular_componentgrowth cone
D0038007biological_processnetrin-activated signaling pathway
D0042277molecular_functionpeptide binding
D0042995cellular_componentcell projection
D0043025cellular_componentneuronal cell body
D0045171cellular_componentintercellular bridge
D0046872molecular_functionmetal ion binding
D0070062cellular_componentextracellular exosome
D0071944cellular_componentcell periphery
D0072686cellular_componentmitotic spindle
D1990791biological_processdorsal root ganglion development
D1990890molecular_functionnetrin receptor binding
E0000226biological_processmicrotubule cytoskeleton organization
E0000278biological_processmitotic cell cycle
E0003725molecular_functiondouble-stranded RNA binding
E0003924molecular_functionGTPase activity
E0005198molecular_functionstructural molecule activity
E0005200molecular_functionstructural constituent of cytoskeleton
E0005515molecular_functionprotein binding
E0005525molecular_functionGTP binding
E0005737cellular_componentcytoplasm
E0005856cellular_componentcytoskeleton
E0005874cellular_componentmicrotubule
E0005881cellular_componentcytoplasmic microtubule
E0007017biological_processmicrotubule-based process
E0015630cellular_componentmicrotubule cytoskeleton
E0016787molecular_functionhydrolase activity
E0030705biological_processcytoskeleton-dependent intracellular transport
E0031625molecular_functionubiquitin protein ligase binding
E0051301biological_processcell division
E0071353biological_processcellular response to interleukin-4
F0000226biological_processmicrotubule cytoskeleton organization
F0000278biological_processmitotic cell cycle
F0003924molecular_functionGTPase activity
F0005200molecular_functionstructural constituent of cytoskeleton
F0005515molecular_functionprotein binding
F0005525molecular_functionGTP binding
F0005634cellular_componentnucleus
F0005737cellular_componentcytoplasm
F0005856cellular_componentcytoskeleton
F0005874cellular_componentmicrotubule
F0007017biological_processmicrotubule-based process
F0007411biological_processaxon guidance
F0015630cellular_componentmicrotubule cytoskeleton
F0030027cellular_componentlamellipodium
F0030175cellular_componentfilopodium
F0030182biological_processneuron differentiation
F0030424cellular_componentaxon
F0030425cellular_componentdendrite
F0030426cellular_componentgrowth cone
F0038007biological_processnetrin-activated signaling pathway
F0042277molecular_functionpeptide binding
F0042995cellular_componentcell projection
F0043025cellular_componentneuronal cell body
F0045171cellular_componentintercellular bridge
F0046872molecular_functionmetal ion binding
F0070062cellular_componentextracellular exosome
F0071944cellular_componentcell periphery
F0072686cellular_componentmitotic spindle
F1990791biological_processdorsal root ganglion development
F1990890molecular_functionnetrin receptor binding
G0000226biological_processmicrotubule cytoskeleton organization
G0000278biological_processmitotic cell cycle
G0003924molecular_functionGTPase activity
G0005200molecular_functionstructural constituent of cytoskeleton
G0005515molecular_functionprotein binding
G0005525molecular_functionGTP binding
G0005634cellular_componentnucleus
G0005737cellular_componentcytoplasm
G0005856cellular_componentcytoskeleton
G0005874cellular_componentmicrotubule
G0007017biological_processmicrotubule-based process
G0007411biological_processaxon guidance
G0015630cellular_componentmicrotubule cytoskeleton
G0030027cellular_componentlamellipodium
G0030175cellular_componentfilopodium
G0030182biological_processneuron differentiation
G0030424cellular_componentaxon
G0030425cellular_componentdendrite
G0030426cellular_componentgrowth cone
G0038007biological_processnetrin-activated signaling pathway
G0042277molecular_functionpeptide binding
G0042995cellular_componentcell projection
G0043025cellular_componentneuronal cell body
G0045171cellular_componentintercellular bridge
G0046872molecular_functionmetal ion binding
G0070062cellular_componentextracellular exosome
G0071944cellular_componentcell periphery
G0072686cellular_componentmitotic spindle
G1990791biological_processdorsal root ganglion development
G1990890molecular_functionnetrin receptor binding
H0000226biological_processmicrotubule cytoskeleton organization
H0000278biological_processmitotic cell cycle
H0003924molecular_functionGTPase activity
H0005200molecular_functionstructural constituent of cytoskeleton
H0005515molecular_functionprotein binding
H0005525molecular_functionGTP binding
H0005634cellular_componentnucleus
H0005737cellular_componentcytoplasm
H0005856cellular_componentcytoskeleton
H0005874cellular_componentmicrotubule
H0007017biological_processmicrotubule-based process
H0007411biological_processaxon guidance
H0015630cellular_componentmicrotubule cytoskeleton
H0030027cellular_componentlamellipodium
H0030175cellular_componentfilopodium
H0030182biological_processneuron differentiation
H0030424cellular_componentaxon
H0030425cellular_componentdendrite
H0030426cellular_componentgrowth cone
H0038007biological_processnetrin-activated signaling pathway
H0042277molecular_functionpeptide binding
H0042995cellular_componentcell projection
H0043025cellular_componentneuronal cell body
H0045171cellular_componentintercellular bridge
H0046872molecular_functionmetal ion binding
H0070062cellular_componentextracellular exosome
H0071944cellular_componentcell periphery
H0072686cellular_componentmitotic spindle
H1990791biological_processdorsal root ganglion development
H1990890molecular_functionnetrin receptor binding
I0000226biological_processmicrotubule cytoskeleton organization
I0000278biological_processmitotic cell cycle
I0003924molecular_functionGTPase activity
I0005200molecular_functionstructural constituent of cytoskeleton
I0005515molecular_functionprotein binding
I0005525molecular_functionGTP binding
I0005634cellular_componentnucleus
I0005737cellular_componentcytoplasm
I0005856cellular_componentcytoskeleton
I0005874cellular_componentmicrotubule
I0007017biological_processmicrotubule-based process
I0007411biological_processaxon guidance
I0015630cellular_componentmicrotubule cytoskeleton
I0030027cellular_componentlamellipodium
I0030175cellular_componentfilopodium
I0030182biological_processneuron differentiation
I0030424cellular_componentaxon
I0030425cellular_componentdendrite
I0030426cellular_componentgrowth cone
I0038007biological_processnetrin-activated signaling pathway
I0042277molecular_functionpeptide binding
I0042995cellular_componentcell projection
I0043025cellular_componentneuronal cell body
I0045171cellular_componentintercellular bridge
I0046872molecular_functionmetal ion binding
I0070062cellular_componentextracellular exosome
I0071944cellular_componentcell periphery
I0072686cellular_componentmitotic spindle
I1990791biological_processdorsal root ganglion development
I1990890molecular_functionnetrin receptor binding
J0000226biological_processmicrotubule cytoskeleton organization
J0000278biological_processmitotic cell cycle
J0003725molecular_functiondouble-stranded RNA binding
J0003924molecular_functionGTPase activity
J0005198molecular_functionstructural molecule activity
J0005200molecular_functionstructural constituent of cytoskeleton
J0005515molecular_functionprotein binding
J0005525molecular_functionGTP binding
J0005737cellular_componentcytoplasm
J0005856cellular_componentcytoskeleton
J0005874cellular_componentmicrotubule
J0005881cellular_componentcytoplasmic microtubule
J0007017biological_processmicrotubule-based process
J0015630cellular_componentmicrotubule cytoskeleton
J0016787molecular_functionhydrolase activity
J0030705biological_processcytoskeleton-dependent intracellular transport
J0031625molecular_functionubiquitin protein ligase binding
J0051301biological_processcell division
J0071353biological_processcellular response to interleukin-4
K0000226biological_processmicrotubule cytoskeleton organization
K0000278biological_processmitotic cell cycle
K0003725molecular_functiondouble-stranded RNA binding
K0003924molecular_functionGTPase activity
K0005198molecular_functionstructural molecule activity
K0005200molecular_functionstructural constituent of cytoskeleton
K0005515molecular_functionprotein binding
K0005525molecular_functionGTP binding
K0005737cellular_componentcytoplasm
K0005856cellular_componentcytoskeleton
K0005874cellular_componentmicrotubule
K0005881cellular_componentcytoplasmic microtubule
K0007017biological_processmicrotubule-based process
K0015630cellular_componentmicrotubule cytoskeleton
K0016787molecular_functionhydrolase activity
K0030705biological_processcytoskeleton-dependent intracellular transport
K0031625molecular_functionubiquitin protein ligase binding
K0051301biological_processcell division
K0071353biological_processcellular response to interleukin-4
L0000226biological_processmicrotubule cytoskeleton organization
L0000278biological_processmitotic cell cycle
L0003725molecular_functiondouble-stranded RNA binding
L0003924molecular_functionGTPase activity
L0005198molecular_functionstructural molecule activity
L0005200molecular_functionstructural constituent of cytoskeleton
L0005515molecular_functionprotein binding
L0005525molecular_functionGTP binding
L0005737cellular_componentcytoplasm
L0005856cellular_componentcytoskeleton
L0005874cellular_componentmicrotubule
L0005881cellular_componentcytoplasmic microtubule
L0007017biological_processmicrotubule-based process
L0015630cellular_componentmicrotubule cytoskeleton
L0016787molecular_functionhydrolase activity
L0030705biological_processcytoskeleton-dependent intracellular transport
L0031625molecular_functionubiquitin protein ligase binding
L0051301biological_processcell division
L0071353biological_processcellular response to interleukin-4
M0005515molecular_functionprotein binding
M0005737cellular_componentcytoplasm
M0005815cellular_componentmicrotubule organizing center
M0005856cellular_componentcytoskeleton
M0005874cellular_componentmicrotubule
M0008017molecular_functionmicrotubule binding
M0008104biological_processprotein localization
M0015630cellular_componentmicrotubule cytoskeleton
M0019901molecular_functionprotein kinase binding
M0030496cellular_componentmidbody
M0031110biological_processregulation of microtubule polymerization or depolymerization
M0031113biological_processregulation of microtubule polymerization
M0035371cellular_componentmicrotubule plus-end
M0035372biological_processprotein localization to microtubule
M0042802molecular_functionidentical protein binding
M0045737biological_processpositive regulation of cyclin-dependent protein serine/threonine kinase activity
M0045860biological_processpositive regulation of protein kinase activity
M0045893biological_processpositive regulation of DNA-templated transcription
M0051010molecular_functionmicrotubule plus-end binding
M0051225biological_processspindle assembly
M0051233cellular_componentspindle midzone
M0051301biological_processcell division
M1905721cellular_componentmitotic spindle astral microtubule end
N0005515molecular_functionprotein binding
N0005737cellular_componentcytoplasm
N0005815cellular_componentmicrotubule organizing center
N0005856cellular_componentcytoskeleton
N0005874cellular_componentmicrotubule
N0008017molecular_functionmicrotubule binding
N0008104biological_processprotein localization
N0015630cellular_componentmicrotubule cytoskeleton
N0019901molecular_functionprotein kinase binding
N0030496cellular_componentmidbody
N0031110biological_processregulation of microtubule polymerization or depolymerization
N0031113biological_processregulation of microtubule polymerization
N0035371cellular_componentmicrotubule plus-end
N0035372biological_processprotein localization to microtubule
N0042802molecular_functionidentical protein binding
N0045737biological_processpositive regulation of cyclin-dependent protein serine/threonine kinase activity
N0045860biological_processpositive regulation of protein kinase activity
N0045893biological_processpositive regulation of DNA-templated transcription
N0051010molecular_functionmicrotubule plus-end binding
N0051225biological_processspindle assembly
N0051233cellular_componentspindle midzone
N0051301biological_processcell division
N1905721cellular_componentmitotic spindle astral microtubule end
Functional Information from PROSITE/UniProt
site_idPS00227
Number of Residues7
DetailsTUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG
ChainResidueDetails
BGLY140-GLY146
AGLY142-GLY148

site_idPS00228
Number of Residues4
DetailsTUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREI
ChainResidueDetails
BMET1-ILE4

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
DGLN11
DGLY142
DTHR143
DGLY144
DASN204
DASN226
FGLN11
FGLY142
FTHR143
FGLY144
FASN204
FASN226
GGLN11
GGLY142
GTHR143
GGLY144
GASN204
GASN226
HGLN11
HGLY142
HTHR143
HGLY144
HASN204
HASN226
IGLN11
IGLY142
ITHR143
IGLY144
IASN204
IASN226
BTHR143
BGLY144
BASN204
BASN226
MSER162
NSER162

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q6PER3
ChainResidueDetails
AASN206
AASN228
CGLN11
CGLU71
CSER140
CGLY144
CTHR145
CTHR179
CASN206
CASN228
EGLN11
EGLU71
ESER140
EGLY144
ETHR145
ETHR179
EASN206
EASN228
JGLN11
JGLU71
JSER140
JGLY144
JTHR145
JTHR179
JASN206
JASN228
KGLN11
KGLU71
KSER140
KGLY144
KTHR145
KTHR179
KASN206
KASN228
LGLN11
LGLU71
LSER140
LGLY144
LTHR145
LTHR179
LASN206
LASN228
FGLU69
GGLU69
HGLU69
IGLU69
MSER176
NSER176

site_idSWS_FT_FI3
Number of Residues6
DetailsBINDING: BINDING => ECO:0000305|PubMed:34996871, ECO:0007744|PDB:7SJ7
ChainResidueDetails
FSER138
GSER138
HSER138
ISER138
BSER138
DSER138

site_idSWS_FT_FI4
Number of Residues6
DetailsMOD_RES: Phosphoserine; by CDK1 => ECO:0000269|PubMed:16371510
ChainResidueDetails
BSER172
DSER172
FSER172
GSER172
HSER172
ISER172

site_idSWS_FT_FI5
Number of Residues6
DetailsMOD_RES: 5-glutamyl polyglutamate => ECO:0000250|UniProtKB:Q2T9S0
ChainResidueDetails
JSER48
JSER232
KSER48
KSER232
LSER48
LSER232
BGLU438
DGLU438
FGLU438
GGLU438
HGLU438
IGLU438

site_idSWS_FT_FI6
Number of Residues6
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q2T9S0
ChainResidueDetails
GSER444
BSER444
DSER444
FSER444
HSER444
ISER444

site_idSWS_FT_FI7
Number of Residues6
DetailsMOD_RES: Omega-N-methylarginine => ECO:0000269|Ref.6
ChainResidueDetails
AARG339
CARG339
EARG339
JARG339
KARG339
LARG339

site_idSWS_FT_FI8
Number of Residues6
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P68373
ChainResidueDetails
ASER439
CSER439
ESER439
JSER439
KSER439
LSER439

site_idSWS_FT_FI9
Number of Residues6
DetailsMOD_RES: 5-glutamyl polyglutamate => ECO:0000269|PubMed:32747782
ChainResidueDetails
AGLU443
CGLU443
EGLU443
JGLU443
KGLU443
LGLU443

site_idSWS_FT_FI10
Number of Residues6
DetailsMOD_RES: 5-glutamyl polyglutamate => ECO:0000250|UniProtKB:P68369
ChainResidueDetails
AGLU445
CGLU445
EGLU445
JGLU445
KGLU445
LGLU445

site_idSWS_FT_FI11
Number of Residues6
DetailsMOD_RES: 3'-nitrotyrosine => ECO:0000269|PubMed:10339593
ChainResidueDetails
CTYR451
KTYR451
ATYR451
ETYR451
JTYR451
LTYR451

site_idSWS_FT_FI12
Number of Residues18
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
ChainResidueDetails
ALYS326
ALYS370
CLYS326
CLYS370
ELYS326
ELYS370
JLYS326
JLYS370
KLYS326
KLYS370
LLYS326
LLYS370

219869

PDB entries from 2024-05-15

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