Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7RWA

AP2 bound to heparin and Tgn38 tyrosine cargo peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005794	cellular_component	Golgi apparatus
A	0006886	biological_process	intracellular protein transport
A	0016192	biological_process	vesicle-mediated transport
A	0030117	cellular_component	membrane coat
A	0030121	cellular_component	AP-1 adaptor complex
B	0006886	biological_process	intracellular protein transport
B	0015031	biological_process	protein transport
B	0016192	biological_process	vesicle-mediated transport
B	0030117	cellular_component	membrane coat
B	0030276	molecular_function	clathrin binding
M	0002092	biological_process	positive regulation of receptor internalization
M	0005048	molecular_function	signal sequence binding
M	0005515	molecular_function	protein binding
M	0005739	cellular_component	mitochondrion
M	0005886	cellular_component	plasma membrane
M	0005905	cellular_component	clathrin-coated pit
M	0006886	biological_process	intracellular protein transport
M	0006897	biological_process	endocytosis
M	0006900	biological_process	vesicle budding from membrane
M	0008289	molecular_function	lipid binding
M	0009898	cellular_component	cytoplasmic side of plasma membrane
M	0015031	biological_process	protein transport
M	0016192	biological_process	vesicle-mediated transport
M	0030122	cellular_component	AP-2 adaptor complex
M	0030131	cellular_component	clathrin adaptor complex
M	0030141	cellular_component	secretory granule
M	0031410	cellular_component	cytoplasmic vesicle
M	0031623	biological_process	receptor internalization
M	0035615	molecular_function	clathrin adaptor activity
M	0044325	molecular_function	transmembrane transporter binding
M	0045202	cellular_component	synapse
M	0048488	biological_process	synaptic vesicle endocytosis
M	0050750	molecular_function	low-density lipoprotein particle receptor binding
M	0051649	biological_process	establishment of localization in cell
M	0065003	biological_process	protein-containing complex assembly
M	0072583	biological_process	clathrin-dependent endocytosis
M	0097494	biological_process	regulation of vesicle size
M	0097718	molecular_function	disordered domain specific binding
M	0098794	cellular_component	postsynapse
M	0098884	biological_process	postsynaptic neurotransmitter receptor internalization
M	0098894	cellular_component	extrinsic component of presynaptic endocytic zone membrane
M	0098978	cellular_component	glutamatergic synapse
M	1900244	biological_process	positive regulation of synaptic vesicle endocytosis
M	1903077	biological_process	negative regulation of protein localization to plasma membrane
S	0005515	molecular_function	protein binding
S	0005737	cellular_component	cytoplasm
S	0005886	cellular_component	plasma membrane
S	0005905	cellular_component	clathrin-coated pit
S	0006886	biological_process	intracellular protein transport
S	0006897	biological_process	endocytosis
S	0009898	cellular_component	cytoplasmic side of plasma membrane
S	0015031	biological_process	protein transport
S	0016192	biological_process	vesicle-mediated transport
S	0030117	cellular_component	membrane coat
S	0030122	cellular_component	AP-2 adaptor complex
S	0035615	molecular_function	clathrin adaptor activity
S	0043231	cellular_component	intracellular membrane-bounded organelle
S	0045202	cellular_component	synapse
S	0048488	biological_process	synaptic vesicle endocytosis
S	0071944	cellular_component	cell periphery
S	0072583	biological_process	clathrin-dependent endocytosis
S	0098794	cellular_component	postsynapse
S	0098884	biological_process	postsynaptic neurotransmitter receptor internalization
S	0098894	cellular_component	extrinsic component of presynaptic endocytic zone membrane
S	0098978	cellular_component	glutamatergic synapse
a	0005794	cellular_component	Golgi apparatus
a	0006886	biological_process	intracellular protein transport
a	0016192	biological_process	vesicle-mediated transport
a	0030117	cellular_component	membrane coat
a	0030121	cellular_component	AP-1 adaptor complex
b	0006886	biological_process	intracellular protein transport
b	0015031	biological_process	protein transport
b	0016192	biological_process	vesicle-mediated transport
b	0030117	cellular_component	membrane coat
b	0030276	molecular_function	clathrin binding
m	0002092	biological_process	positive regulation of receptor internalization
m	0005048	molecular_function	signal sequence binding
m	0005515	molecular_function	protein binding
m	0005739	cellular_component	mitochondrion
m	0005886	cellular_component	plasma membrane
m	0005905	cellular_component	clathrin-coated pit
m	0006886	biological_process	intracellular protein transport
m	0006897	biological_process	endocytosis
m	0006900	biological_process	vesicle budding from membrane
m	0008289	molecular_function	lipid binding
m	0009898	cellular_component	cytoplasmic side of plasma membrane
m	0015031	biological_process	protein transport
m	0016192	biological_process	vesicle-mediated transport
m	0030122	cellular_component	AP-2 adaptor complex
m	0030131	cellular_component	clathrin adaptor complex
m	0030141	cellular_component	secretory granule
m	0031410	cellular_component	cytoplasmic vesicle
m	0031623	biological_process	receptor internalization
m	0035615	molecular_function	clathrin adaptor activity
m	0044325	molecular_function	transmembrane transporter binding
m	0045202	cellular_component	synapse
m	0048488	biological_process	synaptic vesicle endocytosis
m	0050750	molecular_function	low-density lipoprotein particle receptor binding
m	0051649	biological_process	establishment of localization in cell
m	0065003	biological_process	protein-containing complex assembly
m	0072583	biological_process	clathrin-dependent endocytosis
m	0097494	biological_process	regulation of vesicle size
m	0097718	molecular_function	disordered domain specific binding
m	0098794	cellular_component	postsynapse
m	0098884	biological_process	postsynaptic neurotransmitter receptor internalization
m	0098894	cellular_component	extrinsic component of presynaptic endocytic zone membrane
m	0098978	cellular_component	glutamatergic synapse
m	1900244	biological_process	positive regulation of synaptic vesicle endocytosis
m	1903077	biological_process	negative regulation of protein localization to plasma membrane
s	0005515	molecular_function	protein binding
s	0005737	cellular_component	cytoplasm
s	0005886	cellular_component	plasma membrane
s	0005905	cellular_component	clathrin-coated pit
s	0006886	biological_process	intracellular protein transport
s	0006897	biological_process	endocytosis
s	0009898	cellular_component	cytoplasmic side of plasma membrane
s	0015031	biological_process	protein transport
s	0016192	biological_process	vesicle-mediated transport
s	0030117	cellular_component	membrane coat
s	0030122	cellular_component	AP-2 adaptor complex
s	0035615	molecular_function	clathrin adaptor activity
s	0043231	cellular_component	intracellular membrane-bounded organelle
s	0045202	cellular_component	synapse
s	0048488	biological_process	synaptic vesicle endocytosis
s	0071944	cellular_component	cell periphery
s	0072583	biological_process	clathrin-dependent endocytosis
s	0098794	cellular_component	postsynapse
s	0098884	biological_process	postsynaptic neurotransmitter receptor internalization
s	0098894	cellular_component	extrinsic component of presynaptic endocytic zone membrane
s	0098978	cellular_component	glutamatergic synapse

Functional Information from PROSITE/UniProt

site_id	PS00989
Number of Residues	11
Details	CLAT_ADAPTOR_S Clathrin adaptor complexes small chain signature. IIYRryagLYF

Chain	Residue	Details
S	ILE57-PHE67

site_id	PS00990
Number of Residues	21
Details	CLAT_ADAPTOR_M_1 Clathrin adaptor complexes medium chain signature 1. IGWRre.GikYrrNeLFLDVLE

Chain	Residue	Details
M	ILE159-GLU179

site_id	PS00991
Number of Residues	15
Details	CLAT_ADAPTOR_M_2 Clathrin adaptor complexes medium chain signature 2. IsFIPPdGeFeLmrY

Chain	Residue	Details
M	ILE263-TYR277

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P53680

Chain	Residue	Details
S	SER140
s	SER140
M	LYS354
m	LYS341
m	LYS345
m	LYS354
a	TYR53
a	LYS57

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:Q96CW1

Chain	Residue	Details
M	SER45
m	SER45

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:21183079

Chain	Residue	Details
M	THR156
m	THR156

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)