7R3H

PROSS optimitzed variant of RhlR (75 mutations) in complex with native autoinducer C4-HSL

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000976	molecular_function	transcription cis-regulatory region binding
A	0001216	molecular_function	DNA-binding transcription activator activity
A	0001217	molecular_function	DNA-binding transcription repressor activity
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0005737	cellular_component	cytoplasm
A	0006355	biological_process	regulation of DNA-templated transcription
A	0009372	biological_process	quorum sensing
A	0010467	biological_process	gene expression
A	0032993	cellular_component	protein-DNA complex
A	0038023	molecular_function	signaling receptor activity
A	0045862	biological_process	positive regulation of proteolysis
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	0046889	biological_process	positive regulation of lipid biosynthetic process
A	0062162	biological_process	positive regulation of pyocyanine biosynthetic process
A	1900378	biological_process	positive regulation of secondary metabolite biosynthetic process
B	0000976	molecular_function	transcription cis-regulatory region binding
B	0001216	molecular_function	DNA-binding transcription activator activity
B	0001217	molecular_function	DNA-binding transcription repressor activity
B	0003677	molecular_function	DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0005737	cellular_component	cytoplasm
B	0006355	biological_process	regulation of DNA-templated transcription
B	0009372	biological_process	quorum sensing
B	0010467	biological_process	gene expression
B	0032993	cellular_component	protein-DNA complex
B	0038023	molecular_function	signaling receptor activity
B	0045862	biological_process	positive regulation of proteolysis
B	0045892	biological_process	negative regulation of DNA-templated transcription
B	0045893	biological_process	positive regulation of DNA-templated transcription
B	0046889	biological_process	positive regulation of lipid biosynthetic process
B	0062162	biological_process	positive regulation of pyocyanine biosynthetic process
B	1900378	biological_process	positive regulation of secondary metabolite biosynthetic process
C	0000976	molecular_function	transcription cis-regulatory region binding
C	0001216	molecular_function	DNA-binding transcription activator activity
C	0001217	molecular_function	DNA-binding transcription repressor activity
C	0003677	molecular_function	DNA binding
C	0003700	molecular_function	DNA-binding transcription factor activity
C	0005737	cellular_component	cytoplasm
C	0006355	biological_process	regulation of DNA-templated transcription
C	0009372	biological_process	quorum sensing
C	0010467	biological_process	gene expression
C	0032993	cellular_component	protein-DNA complex
C	0038023	molecular_function	signaling receptor activity
C	0045862	biological_process	positive regulation of proteolysis
C	0045892	biological_process	negative regulation of DNA-templated transcription
C	0045893	biological_process	positive regulation of DNA-templated transcription
C	0046889	biological_process	positive regulation of lipid biosynthetic process
C	0062162	biological_process	positive regulation of pyocyanine biosynthetic process
C	1900378	biological_process	positive regulation of secondary metabolite biosynthetic process
D	0000976	molecular_function	transcription cis-regulatory region binding
D	0001216	molecular_function	DNA-binding transcription activator activity
D	0001217	molecular_function	DNA-binding transcription repressor activity
D	0003677	molecular_function	DNA binding
D	0003700	molecular_function	DNA-binding transcription factor activity
D	0005737	cellular_component	cytoplasm
D	0006355	biological_process	regulation of DNA-templated transcription
D	0009372	biological_process	quorum sensing
D	0010467	biological_process	gene expression
D	0032993	cellular_component	protein-DNA complex
D	0038023	molecular_function	signaling receptor activity
D	0045862	biological_process	positive regulation of proteolysis
D	0045892	biological_process	negative regulation of DNA-templated transcription
D	0045893	biological_process	positive regulation of DNA-templated transcription
D	0046889	biological_process	positive regulation of lipid biosynthetic process
D	0062162	biological_process	positive regulation of pyocyanine biosynthetic process
D	1900378	biological_process	positive regulation of secondary metabolite biosynthetic process

Functional Information from PROSITE/UniProt

site_id	PS00622
Number of Residues	28
Details	HTH_LUXR_1 LuxR-type HTH domain signature. GktSaeIAkiLgIsesTVnfHlkNIqkK

Chain	Residue	Details
B	GLY195-LYS222

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	76
Details	DNA_BIND: H-T-H motif => ECO:0000255|PROSITE-ProRule:PRU00411

Chain	Residue	Details
B	SER198-LYS217
A	SER198-LYS217
C	SER198-LYS217
D	SER198-LYS217

---