7R1I

Crystal structure of CYP125 from Mycobacterium tuberculosis in complex with an inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004497	molecular_function	monooxygenase activity
A	0005506	molecular_function	iron ion binding
A	0006707	biological_process	cholesterol catabolic process
A	0008203	biological_process	cholesterol metabolic process
A	0008395	molecular_function	steroid hydroxylase activity
A	0016042	biological_process	lipid catabolic process
A	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A	0020037	molecular_function	heme binding
A	0036199	molecular_function	cholest-4-en-3-one 26-monooxygenase activity
A	0046872	molecular_function	metal ion binding
A	0051701	biological_process	biological process involved in interaction with host
B	0004497	molecular_function	monooxygenase activity
B	0005506	molecular_function	iron ion binding
B	0006707	biological_process	cholesterol catabolic process
B	0008203	biological_process	cholesterol metabolic process
B	0008395	molecular_function	steroid hydroxylase activity
B	0016042	biological_process	lipid catabolic process
B	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
B	0020037	molecular_function	heme binding
B	0036199	molecular_function	cholest-4-en-3-one 26-monooxygenase activity
B	0046872	molecular_function	metal ion binding
B	0051701	biological_process	biological process involved in interaction with host
C	0004497	molecular_function	monooxygenase activity
C	0005506	molecular_function	iron ion binding
C	0006707	biological_process	cholesterol catabolic process
C	0008203	biological_process	cholesterol metabolic process
C	0008395	molecular_function	steroid hydroxylase activity
C	0016042	biological_process	lipid catabolic process
C	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
C	0020037	molecular_function	heme binding
C	0036199	molecular_function	cholest-4-en-3-one 26-monooxygenase activity
C	0046872	molecular_function	metal ion binding
C	0051701	biological_process	biological process involved in interaction with host

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:19846552, ECO:0007744|PDB:3IW1

Chain	Residue	Details
A	GLY202
B	GLY202
C	GLY202

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site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: axial binding residue => ECO:0000269|PubMed:20545858, ECO:0007744|PDB:2X5L, ECO:0007744|PDB:2X5W, ECO:0007744|PDB:2XC3, ECO:0007744|PDB:2XN8, ECO:0007744|PDB:3IVY, ECO:0007744|PDB:3IW0, ECO:0007744|PDB:3IW1, ECO:0007744|PDB:3IW2

Chain	Residue	Details
A	CYS377
B	CYS377
C	CYS377

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