7QSR

CryoEM structure of the Ectodomain of Human PLA2R

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001819	biological_process	positive regulation of cytokine production
A	0005576	cellular_component	extracellular region
A	0005886	cellular_component	plasma membrane
A	0006897	biological_process	endocytosis
A	0006898	biological_process	receptor-mediated endocytosis
A	0009986	cellular_component	cell surface
A	0030246	molecular_function	carbohydrate binding
A	0038023	molecular_function	signaling receptor activity
A	0043235	cellular_component	receptor complex
A	0043274	molecular_function	phospholipase binding
A	0043517	biological_process	positive regulation of DNA damage response, signal transduction by p53 class mediator
A	0072593	biological_process	reactive oxygen species metabolic process
A	0090238	biological_process	positive regulation of arachidonic acid secretion
A	0090399	biological_process	replicative senescence
A	0090403	biological_process	oxidative stress-induced premature senescence
A	1900138	biological_process	negative regulation of phospholipase A2 activity
A	1900139	biological_process	negative regulation of arachidonic acid secretion
A	1904635	biological_process	positive regulation of podocyte apoptotic process

Functional Information from PROSITE/UniProt

site_id	PS00023
Number of Residues	42
Details	FN2_1 Fibronectin type-II collagen-binding domain signature. CmfPFqYnhqwhheCtregreddllWCattsRYerdekWgFC

Chain	Residue	Details
A	CYS178-CYS219

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site_id	PS00615
Number of Residues	25
Details	C_TYPE_LECTIN_1 C-type lectin domain signature. CGtfssfmpsa...WRSRDCestlp.YIC

Chain	Residue	Details
A	CYS330-CYS354
A	CYS914-CYS937
A	CYS1209-CYS1232

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1376
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
A	GLU21-SER1397

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site_id	SWS_FT_FI2
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN93
A	ASN454

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site_id	SWS_FT_FI3
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498

Chain	Residue	Details
A	ASN1123

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