7P3B

Human RNA ligase RTCB in complex with GMP and Co(II)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001701	biological_process	in utero embryonic development
A	0001890	biological_process	placenta development
A	0003723	molecular_function	RNA binding
A	0003972	molecular_function	RNA ligase (ATP) activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005634	cellular_component	nucleus
A	0005635	cellular_component	nuclear envelope
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005829	cellular_component	cytosol
A	0006388	biological_process	tRNA splicing, via endonucleolytic cleavage and ligation
A	0006396	biological_process	RNA processing
A	0008033	biological_process	tRNA processing
A	0008452	molecular_function	RNA ligase activity
A	0016874	molecular_function	ligase activity
A	0016886	molecular_function	ligase activity, forming phosphoric ester bonds
A	0017166	molecular_function	vinculin binding
A	0043231	cellular_component	intracellular membrane-bounded organelle
A	0046872	molecular_function	metal ion binding
A	0072669	cellular_component	tRNA-splicing ligase complex
A	0170057	molecular_function	RNA ligase (GTP) activity
B	0001701	biological_process	in utero embryonic development
B	0001890	biological_process	placenta development
B	0003723	molecular_function	RNA binding
B	0003972	molecular_function	RNA ligase (ATP) activity
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005634	cellular_component	nucleus
B	0005635	cellular_component	nuclear envelope
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005829	cellular_component	cytosol
B	0006388	biological_process	tRNA splicing, via endonucleolytic cleavage and ligation
B	0006396	biological_process	RNA processing
B	0008033	biological_process	tRNA processing
B	0008452	molecular_function	RNA ligase activity
B	0016874	molecular_function	ligase activity
B	0016886	molecular_function	ligase activity, forming phosphoric ester bonds
B	0017166	molecular_function	vinculin binding
B	0043231	cellular_component	intracellular membrane-bounded organelle
B	0046872	molecular_function	metal ion binding
B	0072669	cellular_component	tRNA-splicing ligase complex
B	0170057	molecular_function	RNA ligase (GTP) activity

Functional Information from PROSITE/UniProt

site_id	PS01288
Number of Residues	30
Details	UPF0027 Uncharacterized protein family UPF0027 signature. QIgNvAaLPgIvhrsigLPDvHsGyGfaIG

Chain	Residue	Details
A	GLN68-GLY97

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: GMP-histidine intermediate => ECO:0000250|UniProtKB:O59245, ECO:0000255|HAMAP-Rule:MF_03144

Chain	Residue	Details
A	HIS428
B	HIS428

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site_id	SWS_FT_FI2
Number of Residues	20
Details	BINDING: BINDING => ECO:0000250|UniProtKB:O59245, ECO:0000255|HAMAP-Rule:MF_03144

Chain	Residue	Details
A	ASN226
A	HIS227
A	HIS259
A	HIS353
A	GLY402
A	SER409
A	HIS428
A	LYS504
B	ASP119
B	CYS122
B	ASN226
B	HIS227
B	HIS259
B	HIS353
B	GLY402
B	SER409
B	HIS428
B	LYS504
A	ASP119
A	CYS122

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER300
B	SER300

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site_id	SWS_FT_FI4
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
B	LYS496
A	LYS496

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