7N1V
Structural basis for enhanced infectivity and immune evasion of SARS-CoV-2 variants
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016020 | cellular_component | membrane |
| A | 0019031 | cellular_component | viral envelope |
| A | 0019064 | biological_process | fusion of virus membrane with host plasma membrane |
| A | 0039654 | biological_process | fusion of virus membrane with host endosome membrane |
| A | 0046813 | biological_process | receptor-mediated virion attachment to host cell |
| A | 0055036 | cellular_component | virion membrane |
| A | 0075509 | biological_process | endocytosis involved in viral entry into host cell |
| B | 0016020 | cellular_component | membrane |
| B | 0019031 | cellular_component | viral envelope |
| B | 0019064 | biological_process | fusion of virus membrane with host plasma membrane |
| B | 0039654 | biological_process | fusion of virus membrane with host endosome membrane |
| B | 0046813 | biological_process | receptor-mediated virion attachment to host cell |
| B | 0055036 | cellular_component | virion membrane |
| B | 0075509 | biological_process | endocytosis involved in viral entry into host cell |
| C | 0016020 | cellular_component | membrane |
| C | 0019031 | cellular_component | viral envelope |
| C | 0019064 | biological_process | fusion of virus membrane with host plasma membrane |
| C | 0039654 | biological_process | fusion of virus membrane with host endosome membrane |
| C | 0046813 | biological_process | receptor-mediated virion attachment to host cell |
| C | 0055036 | cellular_component | virion membrane |
| C | 0075509 | biological_process | endocytosis involved in viral entry into host cell |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3597 |
| Details | TOPO_DOM: Extracellular => ECO:0000255|HAMAP-Rule:MF_04099 |
| Chain | Residue | Details |
| A | GLN14-ILE1216 | |
| B | GLN14-ILE1216 | |
| C | GLN14-ILE1216 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 60 |
| Details | TRANSMEM: Helical => ECO:0000255|HAMAP-Rule:MF_04099 |
| Chain | Residue | Details |
| A | TRP1217-MET1237 | |
| B | TRP1217-MET1237 | |
| C | TRP1217-MET1237 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 114 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255|HAMAP-Rule:MF_04099 |
| Chain | Residue | Details |
| A | THR1238-GLY1276 | |
| B | THR1238-GLY1276 | |
| C | THR1238-GLY1276 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | SITE: Cleavage; by host furin => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32142651, ECO:0000269|PubMed:32362314, ECO:0000269|PubMed:32703818, ECO:0000269|PubMed:34159616 |
| Chain | Residue | Details |
| B | ALA688 | |
| C | ALA688 | |
| A | ALA688 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | SITE: Cleavage; by host TMPRSS2 or CTSL => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32703818, ECO:0000269|PubMed:34159616 |
| Chain | Residue | Details |
| B | ILE818 | |
| C | ILE818 | |
| A | ILE818 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 15 |
| Details | LIPID: S-palmitoyl cysteine; by host ZDHHC20 => ECO:0000269|PubMed:34599882 |
| Chain | Residue | Details |
| B | GLY1246 | |
| C | THR1238 | |
| C | SER1239 | |
| C | CYS1243 | |
| C | LEU1244 | |
| C | GLY1246 | |
| A | THR1238 | |
| A | SER1239 | |
| A | CYS1243 | |
| A | LEU1244 | |
| A | GLY1246 | |
| B | THR1238 | |
| B | SER1239 | |
| B | CYS1243 | |
| B | LEU1244 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 15 |
| Details | LIPID: S-palmitoyl cysteine; by host ZDHHC20; partial => ECO:0000269|PubMed:34599882 |
| Chain | Residue | Details |
| B | GLY1251 | |
| B | CYS1253 | |
| B | PHE1256 | |
| B | ASP1257 | |
| C | CYS1250 | |
| C | GLY1251 | |
| C | CYS1253 | |
| C | PHE1256 | |
| C | ASP1257 | |
| A | CYS1250 | |
| A | GLY1251 | |
| A | CYS1253 | |
| A | PHE1256 | |
| A | ASP1257 | |
| B | CYS1250 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 9 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| B | SER1161 | |
| C | ASN17 | |
| C | SER1161 | |
| C | VAL1176 | |
| A | VAL1176 | |
| B | ASN17 | |
| B | VAL1176 | |
| A | ASN17 | |
| A | SER1161 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 15 |
| Details | CARBOHYD: N-linked (GlcNAc...) (hybrid) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| A | GLN804 | |
| A | THR1077 | |
| B | ASN61 | |
| B | THR124 | |
| B | ILE720 | |
| B | GLN804 | |
| B | THR1077 | |
| C | ASN61 | |
| C | THR124 | |
| C | ILE720 | |
| C | GLN804 | |
| C | THR1077 | |
| A | THR124 | |
| A | ILE720 | |
| A | ASN61 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 9 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| C | THR76 | |
| C | TRP152 | |
| C | LEU1197 | |
| B | THR76 | |
| B | TRP152 | |
| B | LEU1197 | |
| A | TRP152 | |
| A | LEU1197 | |
| A | THR76 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 21 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| A | ARG346 | |
| A | GLU619 | |
| A | TYR660 | |
| A | HIS1101 | |
| B | PHE168 | |
| B | ILE285 | |
| B | ASN334 | |
| B | ARG346 | |
| B | GLU619 | |
| B | TYR660 | |
| B | HIS1101 | |
| C | PHE168 | |
| C | ILE285 | |
| C | ASN334 | |
| C | ARG346 | |
| C | GLU619 | |
| C | TYR660 | |
| C | HIS1101 | |
| A | PHE168 | |
| A | ILE285 | |
| A | ASN334 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (GlcNAc...) (high mannose) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| B | ILE712 | |
| C | ARG237 | |
| C | ILE712 | |
| A | ARG237 | |
| A | ILE712 | |
| B | ARG237 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 3 |
| Details | CARBOHYD: O-linked (GalNAc) threonine; by host => ECO:0000269|PubMed:32363391 |
| Chain | Residue | Details |
| A | ILE326 | |
| B | ILE326 | |
| C | ILE326 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 3 |
| Details | CARBOHYD: O-linked (HexNAc...) serine; by host => ECO:0000269|PubMed:32363391 |
| Chain | Residue | Details |
| A | ARG328 | |
| B | ARG328 | |
| C | ARG328 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) (hybrid) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| A | ASN606 | |
| B | ASN606 | |
| C | ASN606 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 6 |
| Details | CARBOHYD: O-linked (GlcNAc...) threonine; by host GALNT1 => ECO:0000269|PubMed:34732583 |
| Chain | Residue | Details |
| A | ASN679 | |
| A | HIS681 | |
| B | ASN679 | |
| B | HIS681 | |
| C | ASN679 | |
| C | HIS681 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| A | VAL1137 | |
| B | VAL1137 | |
| C | VAL1137 |
