7MK5

Crystal structure of Escherichia coli ClpP covalently inhibited by clipibicyclene

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004176	molecular_function	ATP-dependent peptidase activity
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006508	biological_process	proteolysis
A	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
A	0008236	molecular_function	serine-type peptidase activity
A	0009266	biological_process	response to temperature stimulus
A	0009314	biological_process	response to radiation
A	0009368	cellular_component	endopeptidase Clp complex
A	0009376	cellular_component	HslUV protease complex
A	0009408	biological_process	response to heat
A	0010498	biological_process	proteasomal protein catabolic process
A	0016020	cellular_component	membrane
A	0042802	molecular_function	identical protein binding
A	0043068	biological_process	positive regulation of programmed cell death
A	0051117	molecular_function	ATPase binding
B	0004176	molecular_function	ATP-dependent peptidase activity
B	0004252	molecular_function	serine-type endopeptidase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006508	biological_process	proteolysis
B	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
B	0008236	molecular_function	serine-type peptidase activity
B	0009266	biological_process	response to temperature stimulus
B	0009314	biological_process	response to radiation
B	0009368	cellular_component	endopeptidase Clp complex
B	0009376	cellular_component	HslUV protease complex
B	0009408	biological_process	response to heat
B	0010498	biological_process	proteasomal protein catabolic process
B	0016020	cellular_component	membrane
B	0042802	molecular_function	identical protein binding
B	0043068	biological_process	positive regulation of programmed cell death
B	0051117	molecular_function	ATPase binding
C	0004176	molecular_function	ATP-dependent peptidase activity
C	0004252	molecular_function	serine-type endopeptidase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006508	biological_process	proteolysis
C	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
C	0008236	molecular_function	serine-type peptidase activity
C	0009266	biological_process	response to temperature stimulus
C	0009314	biological_process	response to radiation
C	0009368	cellular_component	endopeptidase Clp complex
C	0009376	cellular_component	HslUV protease complex
C	0009408	biological_process	response to heat
C	0010498	biological_process	proteasomal protein catabolic process
C	0016020	cellular_component	membrane
C	0042802	molecular_function	identical protein binding
C	0043068	biological_process	positive regulation of programmed cell death
C	0051117	molecular_function	ATPase binding
D	0004176	molecular_function	ATP-dependent peptidase activity
D	0004252	molecular_function	serine-type endopeptidase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006508	biological_process	proteolysis
D	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
D	0008236	molecular_function	serine-type peptidase activity
D	0009266	biological_process	response to temperature stimulus
D	0009314	biological_process	response to radiation
D	0009368	cellular_component	endopeptidase Clp complex
D	0009376	cellular_component	HslUV protease complex
D	0009408	biological_process	response to heat
D	0010498	biological_process	proteasomal protein catabolic process
D	0016020	cellular_component	membrane
D	0042802	molecular_function	identical protein binding
D	0043068	biological_process	positive regulation of programmed cell death
D	0051117	molecular_function	ATPase binding
E	0004176	molecular_function	ATP-dependent peptidase activity
E	0004252	molecular_function	serine-type endopeptidase activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006508	biological_process	proteolysis
E	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
E	0008236	molecular_function	serine-type peptidase activity
E	0009266	biological_process	response to temperature stimulus
E	0009314	biological_process	response to radiation
E	0009368	cellular_component	endopeptidase Clp complex
E	0009376	cellular_component	HslUV protease complex
E	0009408	biological_process	response to heat
E	0010498	biological_process	proteasomal protein catabolic process
E	0016020	cellular_component	membrane
E	0042802	molecular_function	identical protein binding
E	0043068	biological_process	positive regulation of programmed cell death
E	0051117	molecular_function	ATPase binding
F	0004176	molecular_function	ATP-dependent peptidase activity
F	0004252	molecular_function	serine-type endopeptidase activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006508	biological_process	proteolysis
F	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
F	0008236	molecular_function	serine-type peptidase activity
F	0009266	biological_process	response to temperature stimulus
F	0009314	biological_process	response to radiation
F	0009368	cellular_component	endopeptidase Clp complex
F	0009376	cellular_component	HslUV protease complex
F	0009408	biological_process	response to heat
F	0010498	biological_process	proteasomal protein catabolic process
F	0016020	cellular_component	membrane
F	0042802	molecular_function	identical protein binding
F	0043068	biological_process	positive regulation of programmed cell death
F	0051117	molecular_function	ATPase binding
G	0004176	molecular_function	ATP-dependent peptidase activity
G	0004252	molecular_function	serine-type endopeptidase activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006508	biological_process	proteolysis
G	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
G	0008236	molecular_function	serine-type peptidase activity
G	0009266	biological_process	response to temperature stimulus
G	0009314	biological_process	response to radiation
G	0009368	cellular_component	endopeptidase Clp complex
G	0009376	cellular_component	HslUV protease complex
G	0009408	biological_process	response to heat
G	0010498	biological_process	proteasomal protein catabolic process
G	0016020	cellular_component	membrane
G	0042802	molecular_function	identical protein binding
G	0043068	biological_process	positive regulation of programmed cell death
G	0051117	molecular_function	ATPase binding
H	0004176	molecular_function	ATP-dependent peptidase activity
H	0004252	molecular_function	serine-type endopeptidase activity
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006508	biological_process	proteolysis
H	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
H	0008236	molecular_function	serine-type peptidase activity
H	0009266	biological_process	response to temperature stimulus
H	0009314	biological_process	response to radiation
H	0009368	cellular_component	endopeptidase Clp complex
H	0009376	cellular_component	HslUV protease complex
H	0009408	biological_process	response to heat
H	0010498	biological_process	proteasomal protein catabolic process
H	0016020	cellular_component	membrane
H	0042802	molecular_function	identical protein binding
H	0043068	biological_process	positive regulation of programmed cell death
H	0051117	molecular_function	ATPase binding
I	0004176	molecular_function	ATP-dependent peptidase activity
I	0004252	molecular_function	serine-type endopeptidase activity
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0006508	biological_process	proteolysis
I	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
I	0008236	molecular_function	serine-type peptidase activity
I	0009266	biological_process	response to temperature stimulus
I	0009314	biological_process	response to radiation
I	0009368	cellular_component	endopeptidase Clp complex
I	0009376	cellular_component	HslUV protease complex
I	0009408	biological_process	response to heat
I	0010498	biological_process	proteasomal protein catabolic process
I	0016020	cellular_component	membrane
I	0042802	molecular_function	identical protein binding
I	0043068	biological_process	positive regulation of programmed cell death
I	0051117	molecular_function	ATPase binding
J	0004176	molecular_function	ATP-dependent peptidase activity
J	0004252	molecular_function	serine-type endopeptidase activity
J	0005515	molecular_function	protein binding
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0006508	biological_process	proteolysis
J	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
J	0008236	molecular_function	serine-type peptidase activity
J	0009266	biological_process	response to temperature stimulus
J	0009314	biological_process	response to radiation
J	0009368	cellular_component	endopeptidase Clp complex
J	0009376	cellular_component	HslUV protease complex
J	0009408	biological_process	response to heat
J	0010498	biological_process	proteasomal protein catabolic process
J	0016020	cellular_component	membrane
J	0042802	molecular_function	identical protein binding
J	0043068	biological_process	positive regulation of programmed cell death
J	0051117	molecular_function	ATPase binding
K	0004176	molecular_function	ATP-dependent peptidase activity
K	0004252	molecular_function	serine-type endopeptidase activity
K	0005515	molecular_function	protein binding
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0006508	biological_process	proteolysis
K	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
K	0008236	molecular_function	serine-type peptidase activity
K	0009266	biological_process	response to temperature stimulus
K	0009314	biological_process	response to radiation
K	0009368	cellular_component	endopeptidase Clp complex
K	0009376	cellular_component	HslUV protease complex
K	0009408	biological_process	response to heat
K	0010498	biological_process	proteasomal protein catabolic process
K	0016020	cellular_component	membrane
K	0042802	molecular_function	identical protein binding
K	0043068	biological_process	positive regulation of programmed cell death
K	0051117	molecular_function	ATPase binding
L	0004176	molecular_function	ATP-dependent peptidase activity
L	0004252	molecular_function	serine-type endopeptidase activity
L	0005515	molecular_function	protein binding
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0006508	biological_process	proteolysis
L	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
L	0008236	molecular_function	serine-type peptidase activity
L	0009266	biological_process	response to temperature stimulus
L	0009314	biological_process	response to radiation
L	0009368	cellular_component	endopeptidase Clp complex
L	0009376	cellular_component	HslUV protease complex
L	0009408	biological_process	response to heat
L	0010498	biological_process	proteasomal protein catabolic process
L	0016020	cellular_component	membrane
L	0042802	molecular_function	identical protein binding
L	0043068	biological_process	positive regulation of programmed cell death
L	0051117	molecular_function	ATPase binding
M	0004176	molecular_function	ATP-dependent peptidase activity
M	0004252	molecular_function	serine-type endopeptidase activity
M	0005515	molecular_function	protein binding
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0006508	biological_process	proteolysis
M	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
M	0008236	molecular_function	serine-type peptidase activity
M	0009266	biological_process	response to temperature stimulus
M	0009314	biological_process	response to radiation
M	0009368	cellular_component	endopeptidase Clp complex
M	0009376	cellular_component	HslUV protease complex
M	0009408	biological_process	response to heat
M	0010498	biological_process	proteasomal protein catabolic process
M	0016020	cellular_component	membrane
M	0042802	molecular_function	identical protein binding
M	0043068	biological_process	positive regulation of programmed cell death
M	0051117	molecular_function	ATPase binding
N	0004176	molecular_function	ATP-dependent peptidase activity
N	0004252	molecular_function	serine-type endopeptidase activity
N	0005515	molecular_function	protein binding
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0006508	biological_process	proteolysis
N	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
N	0008236	molecular_function	serine-type peptidase activity
N	0009266	biological_process	response to temperature stimulus
N	0009314	biological_process	response to radiation
N	0009368	cellular_component	endopeptidase Clp complex
N	0009376	cellular_component	HslUV protease complex
N	0009408	biological_process	response to heat
N	0010498	biological_process	proteasomal protein catabolic process
N	0016020	cellular_component	membrane
N	0042802	molecular_function	identical protein binding
N	0043068	biological_process	positive regulation of programmed cell death
N	0051117	molecular_function	ATPase binding
O	0004176	molecular_function	ATP-dependent peptidase activity
O	0004252	molecular_function	serine-type endopeptidase activity
O	0005515	molecular_function	protein binding
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0006508	biological_process	proteolysis
O	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
O	0008236	molecular_function	serine-type peptidase activity
O	0009266	biological_process	response to temperature stimulus
O	0009314	biological_process	response to radiation
O	0009368	cellular_component	endopeptidase Clp complex
O	0009376	cellular_component	HslUV protease complex
O	0009408	biological_process	response to heat
O	0010498	biological_process	proteasomal protein catabolic process
O	0016020	cellular_component	membrane
O	0042802	molecular_function	identical protein binding
O	0043068	biological_process	positive regulation of programmed cell death
O	0051117	molecular_function	ATPase binding
P	0004176	molecular_function	ATP-dependent peptidase activity
P	0004252	molecular_function	serine-type endopeptidase activity
P	0005515	molecular_function	protein binding
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0006508	biological_process	proteolysis
P	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
P	0008236	molecular_function	serine-type peptidase activity
P	0009266	biological_process	response to temperature stimulus
P	0009314	biological_process	response to radiation
P	0009368	cellular_component	endopeptidase Clp complex
P	0009376	cellular_component	HslUV protease complex
P	0009408	biological_process	response to heat
P	0010498	biological_process	proteasomal protein catabolic process
P	0016020	cellular_component	membrane
P	0042802	molecular_function	identical protein binding
P	0043068	biological_process	positive regulation of programmed cell death
P	0051117	molecular_function	ATPase binding
Q	0004176	molecular_function	ATP-dependent peptidase activity
Q	0004252	molecular_function	serine-type endopeptidase activity
Q	0005515	molecular_function	protein binding
Q	0005737	cellular_component	cytoplasm
Q	0005829	cellular_component	cytosol
Q	0006508	biological_process	proteolysis
Q	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
Q	0008236	molecular_function	serine-type peptidase activity
Q	0009266	biological_process	response to temperature stimulus
Q	0009314	biological_process	response to radiation
Q	0009368	cellular_component	endopeptidase Clp complex
Q	0009376	cellular_component	HslUV protease complex
Q	0009408	biological_process	response to heat
Q	0010498	biological_process	proteasomal protein catabolic process
Q	0016020	cellular_component	membrane
Q	0042802	molecular_function	identical protein binding
Q	0043068	biological_process	positive regulation of programmed cell death
Q	0051117	molecular_function	ATPase binding
R	0004176	molecular_function	ATP-dependent peptidase activity
R	0004252	molecular_function	serine-type endopeptidase activity
R	0005515	molecular_function	protein binding
R	0005737	cellular_component	cytoplasm
R	0005829	cellular_component	cytosol
R	0006508	biological_process	proteolysis
R	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
R	0008236	molecular_function	serine-type peptidase activity
R	0009266	biological_process	response to temperature stimulus
R	0009314	biological_process	response to radiation
R	0009368	cellular_component	endopeptidase Clp complex
R	0009376	cellular_component	HslUV protease complex
R	0009408	biological_process	response to heat
R	0010498	biological_process	proteasomal protein catabolic process
R	0016020	cellular_component	membrane
R	0042802	molecular_function	identical protein binding
R	0043068	biological_process	positive regulation of programmed cell death
R	0051117	molecular_function	ATPase binding
S	0004176	molecular_function	ATP-dependent peptidase activity
S	0004252	molecular_function	serine-type endopeptidase activity
S	0005515	molecular_function	protein binding
S	0005737	cellular_component	cytoplasm
S	0005829	cellular_component	cytosol
S	0006508	biological_process	proteolysis
S	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
S	0008236	molecular_function	serine-type peptidase activity
S	0009266	biological_process	response to temperature stimulus
S	0009314	biological_process	response to radiation
S	0009368	cellular_component	endopeptidase Clp complex
S	0009376	cellular_component	HslUV protease complex
S	0009408	biological_process	response to heat
S	0010498	biological_process	proteasomal protein catabolic process
S	0016020	cellular_component	membrane
S	0042802	molecular_function	identical protein binding
S	0043068	biological_process	positive regulation of programmed cell death
S	0051117	molecular_function	ATPase binding
T	0004176	molecular_function	ATP-dependent peptidase activity
T	0004252	molecular_function	serine-type endopeptidase activity
T	0005515	molecular_function	protein binding
T	0005737	cellular_component	cytoplasm
T	0005829	cellular_component	cytosol
T	0006508	biological_process	proteolysis
T	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
T	0008236	molecular_function	serine-type peptidase activity
T	0009266	biological_process	response to temperature stimulus
T	0009314	biological_process	response to radiation
T	0009368	cellular_component	endopeptidase Clp complex
T	0009376	cellular_component	HslUV protease complex
T	0009408	biological_process	response to heat
T	0010498	biological_process	proteasomal protein catabolic process
T	0016020	cellular_component	membrane
T	0042802	molecular_function	identical protein binding
T	0043068	biological_process	positive regulation of programmed cell death
T	0051117	molecular_function	ATPase binding
U	0004176	molecular_function	ATP-dependent peptidase activity
U	0004252	molecular_function	serine-type endopeptidase activity
U	0005515	molecular_function	protein binding
U	0005737	cellular_component	cytoplasm
U	0005829	cellular_component	cytosol
U	0006508	biological_process	proteolysis
U	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
U	0008236	molecular_function	serine-type peptidase activity
U	0009266	biological_process	response to temperature stimulus
U	0009314	biological_process	response to radiation
U	0009368	cellular_component	endopeptidase Clp complex
U	0009376	cellular_component	HslUV protease complex
U	0009408	biological_process	response to heat
U	0010498	biological_process	proteasomal protein catabolic process
U	0016020	cellular_component	membrane
U	0042802	molecular_function	identical protein binding
U	0043068	biological_process	positive regulation of programmed cell death
U	0051117	molecular_function	ATPase binding
V	0004176	molecular_function	ATP-dependent peptidase activity
V	0004252	molecular_function	serine-type endopeptidase activity
V	0005515	molecular_function	protein binding
V	0005737	cellular_component	cytoplasm
V	0005829	cellular_component	cytosol
V	0006508	biological_process	proteolysis
V	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
V	0008236	molecular_function	serine-type peptidase activity
V	0009266	biological_process	response to temperature stimulus
V	0009314	biological_process	response to radiation
V	0009368	cellular_component	endopeptidase Clp complex
V	0009376	cellular_component	HslUV protease complex
V	0009408	biological_process	response to heat
V	0010498	biological_process	proteasomal protein catabolic process
V	0016020	cellular_component	membrane
V	0042802	molecular_function	identical protein binding
V	0043068	biological_process	positive regulation of programmed cell death
V	0051117	molecular_function	ATPase binding
W	0004176	molecular_function	ATP-dependent peptidase activity
W	0004252	molecular_function	serine-type endopeptidase activity
W	0005515	molecular_function	protein binding
W	0005737	cellular_component	cytoplasm
W	0005829	cellular_component	cytosol
W	0006508	biological_process	proteolysis
W	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
W	0008236	molecular_function	serine-type peptidase activity
W	0009266	biological_process	response to temperature stimulus
W	0009314	biological_process	response to radiation
W	0009368	cellular_component	endopeptidase Clp complex
W	0009376	cellular_component	HslUV protease complex
W	0009408	biological_process	response to heat
W	0010498	biological_process	proteasomal protein catabolic process
W	0016020	cellular_component	membrane
W	0042802	molecular_function	identical protein binding
W	0043068	biological_process	positive regulation of programmed cell death
W	0051117	molecular_function	ATPase binding
X	0004176	molecular_function	ATP-dependent peptidase activity
X	0004252	molecular_function	serine-type endopeptidase activity
X	0005515	molecular_function	protein binding
X	0005737	cellular_component	cytoplasm
X	0005829	cellular_component	cytosol
X	0006508	biological_process	proteolysis
X	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
X	0008236	molecular_function	serine-type peptidase activity
X	0009266	biological_process	response to temperature stimulus
X	0009314	biological_process	response to radiation
X	0009368	cellular_component	endopeptidase Clp complex
X	0009376	cellular_component	HslUV protease complex
X	0009408	biological_process	response to heat
X	0010498	biological_process	proteasomal protein catabolic process
X	0016020	cellular_component	membrane
X	0042802	molecular_function	identical protein binding
X	0043068	biological_process	positive regulation of programmed cell death
X	0051117	molecular_function	ATPase binding
Y	0004176	molecular_function	ATP-dependent peptidase activity
Y	0004252	molecular_function	serine-type endopeptidase activity
Y	0005515	molecular_function	protein binding
Y	0005737	cellular_component	cytoplasm
Y	0005829	cellular_component	cytosol
Y	0006508	biological_process	proteolysis
Y	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
Y	0008236	molecular_function	serine-type peptidase activity
Y	0009266	biological_process	response to temperature stimulus
Y	0009314	biological_process	response to radiation
Y	0009368	cellular_component	endopeptidase Clp complex
Y	0009376	cellular_component	HslUV protease complex
Y	0009408	biological_process	response to heat
Y	0010498	biological_process	proteasomal protein catabolic process
Y	0016020	cellular_component	membrane
Y	0042802	molecular_function	identical protein binding
Y	0043068	biological_process	positive regulation of programmed cell death
Y	0051117	molecular_function	ATPase binding
Z	0004176	molecular_function	ATP-dependent peptidase activity
Z	0004252	molecular_function	serine-type endopeptidase activity
Z	0005515	molecular_function	protein binding
Z	0005737	cellular_component	cytoplasm
Z	0005829	cellular_component	cytosol
Z	0006508	biological_process	proteolysis
Z	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
Z	0008236	molecular_function	serine-type peptidase activity
Z	0009266	biological_process	response to temperature stimulus
Z	0009314	biological_process	response to radiation
Z	0009368	cellular_component	endopeptidase Clp complex
Z	0009376	cellular_component	HslUV protease complex
Z	0009408	biological_process	response to heat
Z	0010498	biological_process	proteasomal protein catabolic process
Z	0016020	cellular_component	membrane
Z	0042802	molecular_function	identical protein binding
Z	0043068	biological_process	positive regulation of programmed cell death
Z	0051117	molecular_function	ATPase binding
a	0004176	molecular_function	ATP-dependent peptidase activity
a	0004252	molecular_function	serine-type endopeptidase activity
a	0005515	molecular_function	protein binding
a	0005737	cellular_component	cytoplasm
a	0005829	cellular_component	cytosol
a	0006508	biological_process	proteolysis
a	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
a	0008236	molecular_function	serine-type peptidase activity
a	0009266	biological_process	response to temperature stimulus
a	0009314	biological_process	response to radiation
a	0009368	cellular_component	endopeptidase Clp complex
a	0009376	cellular_component	HslUV protease complex
a	0009408	biological_process	response to heat
a	0010498	biological_process	proteasomal protein catabolic process
a	0016020	cellular_component	membrane
a	0042802	molecular_function	identical protein binding
a	0043068	biological_process	positive regulation of programmed cell death
a	0051117	molecular_function	ATPase binding
b	0004176	molecular_function	ATP-dependent peptidase activity
b	0004252	molecular_function	serine-type endopeptidase activity
b	0005515	molecular_function	protein binding
b	0005737	cellular_component	cytoplasm
b	0005829	cellular_component	cytosol
b	0006508	biological_process	proteolysis
b	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
b	0008236	molecular_function	serine-type peptidase activity
b	0009266	biological_process	response to temperature stimulus
b	0009314	biological_process	response to radiation
b	0009368	cellular_component	endopeptidase Clp complex
b	0009376	cellular_component	HslUV protease complex
b	0009408	biological_process	response to heat
b	0010498	biological_process	proteasomal protein catabolic process
b	0016020	cellular_component	membrane
b	0042802	molecular_function	identical protein binding
b	0043068	biological_process	positive regulation of programmed cell death
b	0051117	molecular_function	ATPase binding

Functional Information from PROSITE/UniProt

site_id	PS00381
Number of Residues	12
Details	CLP_PROTEASE_SER Endopeptidase Clp serine active site. TicMGqAASMGA

Chain	Residue	Details
A	THR89-ALA100

---

site_id	PS00382
Number of Residues	14
Details	CLP_PROTEASE_HIS Endopeptidase Clp histidine active site. RfclPnsrVMIHQP

Chain	Residue	Details
A	ARG111-PRO124

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	28
Details	ACT_SITE: Nucleophile => ECO:0000305

Chain	Residue	Details
A	SER97
J	SER97
K	SER97
L	SER97
M	SER97
N	SER97
O	SER97
P	SER97
Q	SER97
R	SER97
S	SER97
B	SER97
T	SER97
U	SER97
V	SER97
W	SER97
X	SER97
Y	SER97
Z	SER97
a	SER97
b	SER97
C	SER97
D	SER97
E	SER97
F	SER97
G	SER97
H	SER97
I	SER97

---

site_id	SWS_FT_FI2
Number of Residues	56
Details	ACT_SITE: ACT_SITE => ECO:0000305

Chain	Residue	Details
A	HIS122
E	ASP171
F	HIS122
F	ASP171
G	HIS122
G	ASP171
H	HIS122
H	ASP171
I	HIS122
I	ASP171
J	HIS122
A	ASP171
J	ASP171
K	HIS122
K	ASP171
L	HIS122
L	ASP171
M	HIS122
M	ASP171
N	HIS122
N	ASP171
O	HIS122
B	HIS122
O	ASP171
P	HIS122
P	ASP171
Q	HIS122
Q	ASP171
R	HIS122
R	ASP171
S	HIS122
S	ASP171
T	HIS122
B	ASP171
T	ASP171
U	HIS122
U	ASP171
V	HIS122
V	ASP171
W	HIS122
W	ASP171
X	HIS122
X	ASP171
Y	HIS122
C	HIS122
Y	ASP171
Z	HIS122
Z	ASP171
a	HIS122
a	ASP171
b	HIS122
b	ASP171
C	ASP171
D	HIS122
D	ASP171
E	HIS122

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	5
Details	M-CSA 912

Chain	Residue	Details
A	GLY68	electrostatic stabiliser
A	SER97	covalent catalysis, proton shuttle (general acid/base)
A	MET98	electrostatic stabiliser
A	HIS122	proton shuttle (general acid/base)
A	ASP171	electrostatic stabiliser, modifies pKa

---

site_id	MCSA2
Number of Residues	5
Details	M-CSA 912

Chain	Residue	Details
B	GLY68	electrostatic stabiliser
B	SER97	covalent catalysis, proton shuttle (general acid/base)
B	MET98	electrostatic stabiliser
B	HIS122	proton shuttle (general acid/base)
B	ASP171	electrostatic stabiliser, modifies pKa

---

site_id	MCSA3
Number of Residues	5
Details	M-CSA 912

Chain	Residue	Details
C	GLY68	electrostatic stabiliser
C	SER97	covalent catalysis, proton shuttle (general acid/base)
C	MET98	electrostatic stabiliser
C	HIS122	proton shuttle (general acid/base)
C	ASP171	electrostatic stabiliser, modifies pKa

---

site_id	MCSA4
Number of Residues	5
Details	M-CSA 912

Chain	Residue	Details
D	GLY68	electrostatic stabiliser
D	SER97	covalent catalysis, proton shuttle (general acid/base)
D	MET98	electrostatic stabiliser
D	HIS122	proton shuttle (general acid/base)
D	ASP171	electrostatic stabiliser, modifies pKa

---

site_id	MCSA5
Number of Residues	5
Details	M-CSA 912

Chain	Residue	Details
E	GLY68	electrostatic stabiliser
E	SER97	covalent catalysis, proton shuttle (general acid/base)
E	MET98	electrostatic stabiliser
E	HIS122	proton shuttle (general acid/base)
E	ASP171	electrostatic stabiliser, modifies pKa

---

site_id	MCSA6
Number of Residues	5
Details	M-CSA 912

Chain	Residue	Details
F	GLY68	electrostatic stabiliser
F	SER97	covalent catalysis, proton shuttle (general acid/base)
F	MET98	electrostatic stabiliser
F	HIS122	proton shuttle (general acid/base)
F	ASP171	electrostatic stabiliser, modifies pKa

---

site_id	MCSA7
Number of Residues	5
Details	M-CSA 912

Chain	Residue	Details
G	GLY68	electrostatic stabiliser
G	SER97	covalent catalysis, proton shuttle (general acid/base)
G	MET98	electrostatic stabiliser
G	HIS122	proton shuttle (general acid/base)
G	ASP171	electrostatic stabiliser, modifies pKa

---

site_id	MCSA8
Number of Residues	5
Details	M-CSA 912

Chain	Residue	Details
H	GLY68	electrostatic stabiliser
H	SER97	covalent catalysis, proton shuttle (general acid/base)
H	MET98	electrostatic stabiliser
H	HIS122	proton shuttle (general acid/base)
H	ASP171	electrostatic stabiliser, modifies pKa

---

site_id	MCSA9
Number of Residues	5
Details	M-CSA 912

Chain	Residue	Details
I	GLY68	electrostatic stabiliser
I	SER97	covalent catalysis, proton shuttle (general acid/base)
I	MET98	electrostatic stabiliser
I	HIS122	proton shuttle (general acid/base)
I	ASP171	electrostatic stabiliser, modifies pKa

---

site_id	MCSA10
Number of Residues	5
Details	M-CSA 912

Chain	Residue	Details
J	GLY68	electrostatic stabiliser
J	SER97	covalent catalysis, proton shuttle (general acid/base)
J	MET98	electrostatic stabiliser
J	HIS122	proton shuttle (general acid/base)
J	ASP171	electrostatic stabiliser, modifies pKa

---

site_id	MCSA11
Number of Residues	5
Details	M-CSA 912

Chain	Residue	Details
K	GLY68	electrostatic stabiliser
K	SER97	covalent catalysis, proton shuttle (general acid/base)
K	MET98	electrostatic stabiliser
K	HIS122	proton shuttle (general acid/base)
K	ASP171	electrostatic stabiliser, modifies pKa

---

site_id	MCSA12
Number of Residues	5
Details	M-CSA 912

Chain	Residue	Details
L	GLY68	electrostatic stabiliser
L	SER97	covalent catalysis, proton shuttle (general acid/base)
L	MET98	electrostatic stabiliser
L	HIS122	proton shuttle (general acid/base)
L	ASP171	electrostatic stabiliser, modifies pKa

---

site_id	MCSA13
Number of Residues	5
Details	M-CSA 912

Chain	Residue	Details
M	GLY68	electrostatic stabiliser
M	SER97	covalent catalysis, proton shuttle (general acid/base)
M	MET98	electrostatic stabiliser
M	HIS122	proton shuttle (general acid/base)
M	ASP171	electrostatic stabiliser, modifies pKa

---

site_id	MCSA14
Number of Residues	5
Details	M-CSA 912

Chain	Residue	Details
N	GLY68	electrostatic stabiliser
N	SER97	covalent catalysis, proton shuttle (general acid/base)
N	MET98	electrostatic stabiliser
N	HIS122	proton shuttle (general acid/base)
N	ASP171	electrostatic stabiliser, modifies pKa

---

site_id	MCSA15
Number of Residues	5
Details	M-CSA 912

Chain	Residue	Details
O	GLY68	electrostatic stabiliser
O	SER97	covalent catalysis, proton shuttle (general acid/base)
O	MET98	electrostatic stabiliser
O	HIS122	proton shuttle (general acid/base)
O	ASP171	electrostatic stabiliser, modifies pKa

---

site_id	MCSA16
Number of Residues	5
Details	M-CSA 912

Chain	Residue	Details
P	GLY68	electrostatic stabiliser
P	SER97	covalent catalysis, proton shuttle (general acid/base)
P	MET98	electrostatic stabiliser
P	HIS122	proton shuttle (general acid/base)
P	ASP171	electrostatic stabiliser, modifies pKa

---

site_id	MCSA17
Number of Residues	5
Details	M-CSA 912

Chain	Residue	Details
Q	GLY68	electrostatic stabiliser
Q	SER97	covalent catalysis, proton shuttle (general acid/base)
Q	MET98	electrostatic stabiliser
Q	HIS122	proton shuttle (general acid/base)
Q	ASP171	electrostatic stabiliser, modifies pKa

---

site_id	MCSA18
Number of Residues	5
Details	M-CSA 912

Chain	Residue	Details
R	GLY68	electrostatic stabiliser
R	SER97	covalent catalysis, proton shuttle (general acid/base)
R	MET98	electrostatic stabiliser
R	HIS122	proton shuttle (general acid/base)
R	ASP171	electrostatic stabiliser, modifies pKa

---

site_id	MCSA19
Number of Residues	5
Details	M-CSA 912

Chain	Residue	Details
S	GLY68	electrostatic stabiliser
S	SER97	covalent catalysis, proton shuttle (general acid/base)
S	MET98	electrostatic stabiliser
S	HIS122	proton shuttle (general acid/base)
S	ASP171	electrostatic stabiliser, modifies pKa

---

site_id	MCSA20
Number of Residues	5
Details	M-CSA 912

Chain	Residue	Details
T	GLY68	electrostatic stabiliser
T	SER97	covalent catalysis, proton shuttle (general acid/base)
T	MET98	electrostatic stabiliser
T	HIS122	proton shuttle (general acid/base)
T	ASP171	electrostatic stabiliser, modifies pKa

---

site_id	MCSA21
Number of Residues	5
Details	M-CSA 912

Chain	Residue	Details
U	GLY68	electrostatic stabiliser
U	SER97	covalent catalysis, proton shuttle (general acid/base)
U	MET98	electrostatic stabiliser
U	HIS122	proton shuttle (general acid/base)
U	ASP171	electrostatic stabiliser, modifies pKa

---

site_id	MCSA22
Number of Residues	5
Details	M-CSA 912

Chain	Residue	Details
V	GLY68	electrostatic stabiliser
V	SER97	covalent catalysis, proton shuttle (general acid/base)
V	MET98	electrostatic stabiliser
V	HIS122	proton shuttle (general acid/base)
V	ASP171	electrostatic stabiliser, modifies pKa

---

site_id	MCSA23
Number of Residues	5
Details	M-CSA 912

Chain	Residue	Details
W	GLY68	electrostatic stabiliser
W	SER97	covalent catalysis, proton shuttle (general acid/base)
W	MET98	electrostatic stabiliser
W	HIS122	proton shuttle (general acid/base)
W	ASP171	electrostatic stabiliser, modifies pKa

---

site_id	MCSA24
Number of Residues	5
Details	M-CSA 912

Chain	Residue	Details
X	GLY68	electrostatic stabiliser
X	SER97	covalent catalysis, proton shuttle (general acid/base)
X	MET98	electrostatic stabiliser
X	HIS122	proton shuttle (general acid/base)
X	ASP171	electrostatic stabiliser, modifies pKa

---

site_id	MCSA25
Number of Residues	5
Details	M-CSA 912

Chain	Residue	Details
Y	GLY68	electrostatic stabiliser
Y	SER97	covalent catalysis, proton shuttle (general acid/base)
Y	MET98	electrostatic stabiliser
Y	HIS122	proton shuttle (general acid/base)
Y	ASP171	electrostatic stabiliser, modifies pKa

---

site_id	MCSA26
Number of Residues	5
Details	M-CSA 912

Chain	Residue	Details
Z	GLY68	electrostatic stabiliser
Z	SER97	covalent catalysis, proton shuttle (general acid/base)
Z	MET98	electrostatic stabiliser
Z	HIS122	proton shuttle (general acid/base)
Z	ASP171	electrostatic stabiliser, modifies pKa

---

site_id	MCSA27
Number of Residues	5
Details	M-CSA 912

Chain	Residue	Details
a	GLY68	electrostatic stabiliser
a	SER97	covalent catalysis, proton shuttle (general acid/base)
a	MET98	electrostatic stabiliser
a	HIS122	proton shuttle (general acid/base)
a	ASP171	electrostatic stabiliser, modifies pKa

---

site_id	MCSA28
Number of Residues	5
Details	M-CSA 912

Chain	Residue	Details
b	GLY68	electrostatic stabiliser
b	SER97	covalent catalysis, proton shuttle (general acid/base)
b	MET98	electrostatic stabiliser
b	HIS122	proton shuttle (general acid/base)
b	ASP171	electrostatic stabiliser, modifies pKa

---