Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7M8H

Structure of Memo1 C244S metal binding site mutant at 1.75A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005829	cellular_component	cytosol
A	0032886	biological_process	regulation of microtubule-based process
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005829	cellular_component	cytosol
B	0032886	biological_process	regulation of microtubule-based process
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005829	cellular_component	cytosol
C	0032886	biological_process	regulation of microtubule-based process
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005829	cellular_component	cytosol
D	0032886	biological_process	regulation of microtubule-based process

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	binding site for residue GSH A 301

Chain	Residue
A	SER15
A	TYR289
A	MES304
A	HOH408
A	HOH430
A	HOH460
A	HOH489
A	HOH556
D	SER15
D	TRP16
D	GSH301
A	TRP16
A	HIS49
A	ALA50
A	GLY51
A	TYR54
A	ASP189
A	HIS192
A	VAL287

site_id	AC2
Number of Residues	5
Details	binding site for residue EDO A 302

Chain	Residue
A	GLN167
A	PRO229
A	VAL230
A	ASN254
A	HOH428

site_id	AC3
Number of Residues	5
Details	binding site for residue EDO A 303

Chain	Residue
A	SER37
A	THR38
A	LYS39
A	ARG40
A	HOH645

site_id	AC4
Number of Residues	10
Details	binding site for residue MES A 304

Chain	Residue
A	GLY14
A	SER15
A	TRP16
A	TYR17
A	THR18
A	GLY51
A	TYR52
A	THR53
A	TYR54
A	GSH301

site_id	AC5
Number of Residues	5
Details	binding site for residue EDO A 305

Chain	Residue
A	LYS108
A	GLU112
A	LYS175
A	TYR176
A	HOH402

site_id	AC6
Number of Residues	6
Details	binding site for residue EDO A 306

Chain	Residue
A	ASN25
A	GLU29
A	LYS142
A	GLU145
A	HOH451
A	HOH493

site_id	AC7
Number of Residues	3
Details	binding site for residue EDO A 307

Chain	Residue
A	SER277
A	ASP284
A	SER285

site_id	AC8
Number of Residues	5
Details	binding site for residue PEG A 308

Chain	Residue
A	LYS218
A	MET221
A	SER222
A	LEU271
A	ASN272

site_id	AC9
Number of Residues	2
Details	binding site for residue EDO A 309

Chain	Residue
A	TRP282
B	ARG4

site_id	AD1
Number of Residues	1
Details	binding site for residue EDO A 310

Chain	Residue
A	PRO84

site_id	AD2
Number of Residues	18
Details	binding site for residue GSH B 301

Chain	Residue
B	SER15
B	TRP16
B	HIS49
B	ALA50
B	GLY51
B	TYR54
B	ASP189
B	HIS192
B	VAL287
B	TYR289
B	EDO310
B	HOH402
B	HOH559
B	HOH565
B	HOH590
B	HOH633
C	SER15
C	GSH511

site_id	AD3
Number of Residues	7
Details	binding site for residue EDO B 302

Chain	Residue
B	GLU112
B	THR116
B	LYS175
B	HOH431
B	HOH445
B	HOH475
B	HOH577

site_id	AD4
Number of Residues	7
Details	binding site for residue GOL B 303

Chain	Residue
B	GLU163
B	GLU166
B	GLN167
B	PRO229
B	SER233
B	ASN254
B	HOH516

site_id	AD5
Number of Residues	4
Details	binding site for residue EDO B 304

Chain	Residue
B	ARG211
B	GLU214
B	HIS215
B	HOH523

site_id	AD6
Number of Residues	3
Details	binding site for residue EDO B 305

Chain	Residue
B	HOH605
B	PHE270
B	LEU271

site_id	AD7
Number of Residues	5
Details	binding site for residue EDO B 306

Chain	Residue
B	LYS218
B	SER222
B	GLU225
B	PHE270
B	HOH543

site_id	AD8
Number of Residues	6
Details	binding site for residue EDO B 307

Chain	Residue
B	HIS131
B	HOH427
B	HOH441
C	EDO512
C	HOH701
C	HOH787

site_id	AD9
Number of Residues	2
Details	binding site for residue EDO B 308

Chain	Residue
B	TYR239
B	HIS240

site_id	AE1
Number of Residues	3
Details	binding site for residue EDO B 309

Chain	Residue
B	ASN25
B	HOH413
B	HOH570

site_id	AE2
Number of Residues	8
Details	binding site for residue EDO B 310

Chain	Residue
B	SER15
B	TRP16
B	GLY51
B	TYR52
B	THR53
B	TYR54
B	GSH301
B	HOH559

site_id	AE3
Number of Residues	4
Details	binding site for residue EDO B 311

Chain	Residue
B	TRP114
B	GLY117
B	PHE119
B	HOH420

site_id	AE4
Number of Residues	3
Details	binding site for residue EDO B 312

Chain	Residue
B	TRP114
B	ARG121
B	HOH581

site_id	AE5
Number of Residues	5
Details	binding site for residue GOL C 501

Chain	Residue
C	GLU166
C	GLN167
C	PRO229
C	ASN254
C	HOH706

site_id	AE6
Number of Residues	5
Details	binding site for residue EDO C 502

Chain	Residue
C	ASP284
C	SER285
C	HOH606
C	HOH636
C	HOH660

site_id	AE7
Number of Residues	7
Details	binding site for residue EDO C 503

Chain	Residue
C	SER15
C	TRP16
C	GLY51
C	TYR52
C	THR53
C	GSH511
C	HOH816

site_id	AE8
Number of Residues	4
Details	binding site for residue PEG C 504

Chain	Residue
C	ARG87
C	TRP114
C	GLY117
C	PHE119

site_id	AE9
Number of Residues	3
Details	binding site for residue EDO C 505

Chain	Residue
C	MET221
C	LEU271
C	HOH817

site_id	AF1
Number of Residues	6
Details	binding site for residue EDO C 506

Chain	Residue
C	ARG246
C	HIS247
C	HOH609
C	HOH618
C	HOH775
C	HOH842

site_id	AF2
Number of Residues	2
Details	binding site for residue EDO C 507

Chain	Residue
C	VAL6
C	CYS7

site_id	AF3
Number of Residues	3
Details	binding site for residue EDO C 508

Chain	Residue
C	GLU214
C	HIS215
C	HOH725

site_id	AF4
Number of Residues	5
Details	binding site for residue EDO C 509

Chain	Residue
C	SER37
C	THR38
C	LYS39
C	ARG40
C	HOH751

site_id	AF5
Number of Residues	3
Details	binding site for residue EDO C 510

Chain	Residue
C	ARG4
C	SER92
C	ARG121

site_id	AF6
Number of Residues	17
Details	binding site for residue GSH C 511

Chain	Residue
B	SER15
B	GSH301
B	HOH546
C	SER15
C	TRP16
C	HIS49
C	ALA50
C	GLY51
C	TYR54
C	ASP189
C	HIS192
C	VAL287
C	TYR289
C	EDO503
C	HOH610
C	HOH705
C	HOH843

site_id	AF7
Number of Residues	6
Details	binding site for residue EDO C 512

Chain	Residue
B	EDO307
B	HOH501
B	HOH526
C	HIS131
C	HOH603
C	HOH614

site_id	AF8
Number of Residues	22
Details	binding site for residue GSH D 301

Chain	Residue
A	SER15
A	TRP16
A	GSH301
A	HOH425
A	HOH439
D	SER15
D	TRP16
D	HIS49
D	ALA50
D	GLY51
D	TYR54
D	ASP189
D	HIS192
D	VAL287
D	TYR289
D	MES306
D	HOH406
D	HOH408
D	HOH495
D	HOH497
D	HOH645
D	HOH657

site_id	AF9
Number of Residues	5
Details	binding site for residue EDO D 302

Chain	Residue
D	SER37
D	THR38
D	LYS39
D	ARG40
D	HOH550

site_id	AG1
Number of Residues	3
Details	binding site for residue PEG D 303

Chain	Residue
D	SER222
D	GLU225
D	LEU271

site_id	AG2
Number of Residues	6
Details	binding site for residue EDO D 304

Chain	Residue
D	SER277
D	ASP284
D	SER285
D	HOH424
D	HOH428
D	HOH442

site_id	AG3
Number of Residues	5
Details	binding site for residue EDO D 305

Chain	Residue
D	HIS192
D	THR242
D	SER244
D	ARG246
D	HOH458

site_id	AG4
Number of Residues	9
Details	binding site for residue MES D 306

Chain	Residue
D	GLY14
D	SER15
D	TRP16
D	THR18
D	GLY51
D	TYR52
D	THR53
D	TYR54
D	GSH301

site_id	AG5
Number of Residues	9
Details	binding site for residue MES D 307

Chain	Residue
C	TYR202
C	GLU208
C	ARG280
C	TRP282
D	TRP31
D	GLN34
D	HOH594
D	HOH601
D	HOH642

site_id	AG6
Number of Residues	2
Details	binding site for residue EDO D 308

Chain	Residue
D	ASP94
D	GLN107

site_id	AG7
Number of Residues	7
Details	binding site for residue GOL D 309

Chain	Residue
D	GLU163
D	GLU166
D	GLN167
D	VAL230
D	ASN254
D	HOH402
D	HOH526

site_id	AG8
Number of Residues	4
Details	binding site for residue EDO D 310

Chain	Residue
D	SER37
D	ARG40
D	LYS64
D	HOH623

site_id	AG9
Number of Residues	3
Details	binding site for residue EDO D 311

Chain	Residue
D	ALA19
D	SER20
D	HOH485

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0000250\|UniProtKB:Q91VH6

Chain	Residue	Details
A	TYR210
B	TYR210
C	TYR210
D	TYR210

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)