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7K36

Cryo-EM structure of STRIPAK complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000159cellular_componentprotein phosphatase type 2A complex
A0000775cellular_componentchromosome, centromeric region
A0004722molecular_functionprotein serine/threonine phosphatase activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005694cellular_componentchromosome
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0007059biological_processchromosome segregation
A0007143biological_processfemale meiotic nuclear division
A0015630cellular_componentmicrotubule cytoskeleton
A0016020cellular_componentmembrane
A0016328cellular_componentlateral plasma membrane
A0019888molecular_functionprotein phosphatase regulator activity
A0030425cellular_componentdendrite
A0035331biological_processnegative regulation of hippo signaling
A0035556biological_processintracellular signal transduction
A0040008biological_processregulation of growth
A0042995cellular_componentcell projection
A0043005cellular_componentneuron projection
A0043025cellular_componentneuronal cell body
A0043029biological_processT cell homeostasis
A0045202cellular_componentsynapse
A0045595biological_processregulation of cell differentiation
A0046982molecular_functionprotein heterodimerization activity
A0051232biological_processmeiotic spindle elongation
A0051306biological_processmitotic sister chromatid separation
A0051754biological_processmeiotic sister chromatid cohesion, centromeric
A0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0065003biological_processprotein-containing complex assembly
A0070062cellular_componentextracellular exosome
A0090443cellular_componentFAR/SIN/STRIPAK complex
A0098978cellular_componentglutamatergic synapse
A1903538biological_processregulation of meiotic cell cycle process involved in oocyte maturation
A1990405molecular_functionprotein antigen binding
A2001241biological_processpositive regulation of extrinsic apoptotic signaling pathway in absence of ligand
C0000159cellular_componentprotein phosphatase type 2A complex
C0000278biological_processmitotic cell cycle
C0000775cellular_componentchromosome, centromeric region
C0000922cellular_componentspindle pole
C0001932biological_processregulation of protein phosphorylation
C0004721molecular_functionphosphoprotein phosphatase activity
C0004722molecular_functionprotein serine/threonine phosphatase activity
C0004725molecular_functionprotein tyrosine phosphatase activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005694cellular_componentchromosome
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005886cellular_componentplasma membrane
C0006470biological_processprotein dephosphorylation
C0007498biological_processmesoderm development
C0008287cellular_componentprotein serine/threonine phosphatase complex
C0010288biological_processresponse to lead ion
C0010719biological_processnegative regulation of epithelial to mesenchymal transition
C0015630cellular_componentmicrotubule cytoskeleton
C0016020cellular_componentmembrane
C0016787molecular_functionhydrolase activity
C0017018molecular_functionmyosin phosphatase activity
C0035331biological_processnegative regulation of hippo signaling
C0035556biological_processintracellular signal transduction
C0035970biological_processpeptidyl-threonine dephosphorylation
C0040008biological_processregulation of growth
C0043029biological_processT cell homeostasis
C0045121cellular_componentmembrane raft
C0045202cellular_componentsynapse
C0045595biological_processregulation of cell differentiation
C0046872molecular_functionmetal ion binding
C0046982molecular_functionprotein heterodimerization activity
C0048156molecular_functiontau protein binding
C0050811molecular_functionGABA receptor binding
C0051321biological_processmeiotic cell cycle
C0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
C0070062cellular_componentextracellular exosome
C0070262biological_processpeptidyl-serine dephosphorylation
C0071902biological_processpositive regulation of protein serine/threonine kinase activity
C0090443cellular_componentFAR/SIN/STRIPAK complex
C1900227biological_processpositive regulation of NLRP3 inflammasome complex assembly
C1904526biological_processregulation of microtubule binding
C1904528biological_processpositive regulation of microtubule binding
C1904539biological_processnegative regulation of glycolytic process through fructose-6-phosphate
C2000045biological_processregulation of G1/S transition of mitotic cell cycle
H0005515molecular_functionprotein binding
H0005737cellular_componentcytoplasm
H0005794cellular_componentGolgi apparatus
H0016020cellular_componentmembrane
H0019900molecular_functionkinase binding
H0030674molecular_functionprotein-macromolecule adaptor activity
H0032580cellular_componentGolgi cisterna membrane
H0035331biological_processnegative regulation of hippo signaling
H0043025cellular_componentneuronal cell body
H0043197cellular_componentdendritic spine
H0046872molecular_functionmetal ion binding
H0048471cellular_componentperinuclear region of cytoplasm
H0090443cellular_componentFAR/SIN/STRIPAK complex
I0003674molecular_functionmolecular_function
I0005515molecular_functionprotein binding
I0005634cellular_componentnucleus
I0005737cellular_componentcytoplasm
I0005829cellular_componentcytosol
I0007010biological_processcytoskeleton organization
I0019901molecular_functionprotein kinase binding
I0022604biological_processregulation of cell morphogenesis
I0030674molecular_functionprotein-macromolecule adaptor activity
I0030866biological_processcortical actin cytoskeleton organization
I0031267molecular_functionsmall GTPase binding
I0035331biological_processnegative regulation of hippo signaling
I0070062cellular_componentextracellular exosome
I0090443cellular_componentFAR/SIN/STRIPAK complex
Functional Information from PROSITE/UniProt
site_idPS00125
Number of Residues6
DetailsSER_THR_PHOSPHATASE Serine/threonine specific protein phosphatases signature. LRGNHE
ChainResidueDetails
CLEU114-GLU119

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVTAseDhTLKLWNL
ChainResidueDetails
BLEU411-LEU425
BLEU654-LEU668

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylmethionine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895
ChainResidueDetails
HHIS174
GMET1
IMET1
HCYS97
HHIS169

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
CHIS241
CASN117
CHIS167
ISER59
CHIS59
CASP85

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19367720, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
ISER335
BPHE335
DSER202
DPHE335
ESER202
EPHE335
FSER202
FPHE335
GSER202
GPHE335

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q8C079
ChainResidueDetails
DSER214
ESER214
FSER214
GSER214
ISER339

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
DSER229
ESER229
FSER229
GSER229
ISER788

site_idSWS_FT_FI6
Number of Residues5
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:24275569
ChainResidueDetails
BSER257
DSER257
ESER257
FSER257
GSER257

219869

PDB entries from 2024-05-15

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