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7DTU

Human Calcium-Sensing Receptor bound with L-Trp

Functional Information from GO Data
ChainGOidnamespacecontents
A0001503biological_processossification
A0002931biological_processresponse to ischemia
A0004435molecular_functionphosphatidylinositol phospholipase C activity
A0004930molecular_functionG protein-coupled receptor activity
A0005178molecular_functionintegrin binding
A0005509molecular_functioncalcium ion binding
A0005513biological_processdetection of calcium ion
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0006874biological_processintracellular calcium ion homeostasis
A0007186biological_processG protein-coupled receptor signaling pathway
A0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
A0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
A0007254biological_processJNK cascade
A0007635biological_processchemosensory behavior
A0008284biological_processpositive regulation of cell population proliferation
A0009653biological_processanatomical structure morphogenesis
A0009986cellular_componentcell surface
A0010038biological_processresponse to metal ion
A0010628biological_processpositive regulation of gene expression
A0014070biological_processresponse to organic cyclic compound
A0016020cellular_componentmembrane
A0016323cellular_componentbasolateral plasma membrane
A0016324cellular_componentapical plasma membrane
A0016597molecular_functionamino acid binding
A0019901molecular_functionprotein kinase binding
A0030424cellular_componentaxon
A0032024biological_processpositive regulation of insulin secretion
A0032782biological_processbile acid secretion
A0035729biological_processcellular response to hepatocyte growth factor stimulus
A0042311biological_processvasodilation
A0042803molecular_functionprotein homodimerization activity
A0043025cellular_componentneuronal cell body
A0043679cellular_componentaxon terminus
A0044325molecular_functiontransmembrane transporter binding
A0045907biological_processpositive regulation of vasoconstriction
A0046872molecular_functionmetal ion binding
A0048754biological_processbranching morphogenesis of an epithelial tube
A0050927biological_processpositive regulation of positive chemotaxis
A0051592biological_processresponse to calcium ion
A0051924biological_processregulation of calcium ion transport
A0060613biological_processfat pad development
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0070509biological_processcalcium ion import
A0071305biological_processcellular response to vitamin D
A0071333biological_processcellular response to glucose stimulus
A0071404biological_processcellular response to low-density lipoprotein particle stimulus
A0071456biological_processcellular response to hypoxia
A0071774biological_processresponse to fibroblast growth factor
A0090280biological_processpositive regulation of calcium ion import
A1901653biological_processcellular response to peptide
A1902476biological_processchloride transmembrane transport
B0001503biological_processossification
B0002931biological_processresponse to ischemia
B0004435molecular_functionphosphatidylinositol phospholipase C activity
B0004930molecular_functionG protein-coupled receptor activity
B0005178molecular_functionintegrin binding
B0005509molecular_functioncalcium ion binding
B0005513biological_processdetection of calcium ion
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0006874biological_processintracellular calcium ion homeostasis
B0007186biological_processG protein-coupled receptor signaling pathway
B0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0007254biological_processJNK cascade
B0007635biological_processchemosensory behavior
B0008284biological_processpositive regulation of cell population proliferation
B0009653biological_processanatomical structure morphogenesis
B0009986cellular_componentcell surface
B0010038biological_processresponse to metal ion
B0010628biological_processpositive regulation of gene expression
B0014070biological_processresponse to organic cyclic compound
B0016020cellular_componentmembrane
B0016323cellular_componentbasolateral plasma membrane
B0016324cellular_componentapical plasma membrane
B0016597molecular_functionamino acid binding
B0019901molecular_functionprotein kinase binding
B0030424cellular_componentaxon
B0032024biological_processpositive regulation of insulin secretion
B0032782biological_processbile acid secretion
B0035729biological_processcellular response to hepatocyte growth factor stimulus
B0042311biological_processvasodilation
B0042803molecular_functionprotein homodimerization activity
B0043025cellular_componentneuronal cell body
B0043679cellular_componentaxon terminus
B0044325molecular_functiontransmembrane transporter binding
B0045907biological_processpositive regulation of vasoconstriction
B0046872molecular_functionmetal ion binding
B0048754biological_processbranching morphogenesis of an epithelial tube
B0050927biological_processpositive regulation of positive chemotaxis
B0051592biological_processresponse to calcium ion
B0051924biological_processregulation of calcium ion transport
B0060613biological_processfat pad development
B0070374biological_processpositive regulation of ERK1 and ERK2 cascade
B0070509biological_processcalcium ion import
B0071305biological_processcellular response to vitamin D
B0071333biological_processcellular response to glucose stimulus
B0071404biological_processcellular response to low-density lipoprotein particle stimulus
B0071456biological_processcellular response to hypoxia
B0071774biological_processresponse to fibroblast growth factor
B0090280biological_processpositive regulation of calcium ion import
B1901653biological_processcellular response to peptide
B1902476biological_processchloride transmembrane transport
Functional Information from PROSITE/UniProt
site_idPS00979
Number of Residues19
DetailsG_PROTEIN_RECEP_F3_1 G-protein coupled receptors family 3 signature 1. VaNLLgLFyIPQVSyASSS
ChainResidueDetails
AVAL153-SER171

site_idPS00980
Number of Residues25
DetailsG_PROTEIN_RECEP_F3_2 G-protein coupled receptors family 3 signature 2. CCFeCveCpdgeYsdet.DasACnkC
ChainResidueDetails
ACYS561-CYS585

site_idPS00981
Number of Residues11
DetailsG_PROTEIN_RECEP_F3_3 G-protein coupled receptors family 3 signature 3. FNEAKfITFSM
ChainResidueDetails
APHE801-MET811

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1264
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
ATYR20-PHE612
AGLU671-GLN681
AALA746-SER769
ATYR829-VAL836
BTYR20-PHE612
BGLU671-GLN681
BALA746-SER769
BTYR829-VAL836

site_idSWS_FT_FI2
Number of Residues44
DetailsTRANSMEM: Helical; Name=1 => ECO:0000255
ChainResidueDetails
AGLY613-ILE635
BGLY613-ILE635

site_idSWS_FT_FI3
Number of Residues526
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
ALYS636-GLU649
AARG701-GLN724
ALYS793-LYS805
ALYS863-SER1078
BLYS636-GLU649
BARG701-GLN724
BLYS793-LYS805
BLYS863-SER1078

site_idSWS_FT_FI4
Number of Residues40
DetailsTRANSMEM: Helical; Name=2 => ECO:0000255
ChainResidueDetails
ALEU650-GLY670
BLEU650-GLY670

site_idSWS_FT_FI5
Number of Residues36
DetailsTRANSMEM: Helical; Name=3 => ECO:0000255
ChainResidueDetails
APRO682-ASN700
BPRO682-ASN700

site_idSWS_FT_FI6
Number of Residues40
DetailsTRANSMEM: Helical; Name=4 => ECO:0000255
ChainResidueDetails
APHE725-THR745
BPHE725-THR745

site_idSWS_FT_FI7
Number of Residues44
DetailsTRANSMEM: Helical; Name=5 => ECO:0000255
ChainResidueDetails
ALEU770-PHE792
BLEU770-PHE792

site_idSWS_FT_FI8
Number of Residues44
DetailsTRANSMEM: Helical; Name=6 => ECO:0000255
ChainResidueDetails
APHE806-THR828
BPHE806-THR828

site_idSWS_FT_FI9
Number of Residues50
DetailsTRANSMEM: Helical; Name=7 => ECO:0000255
ChainResidueDetails
AGLU837-PHE862
BGLU837-PHE862

site_idSWS_FT_FI10
Number of Residues12
DetailsBINDING: BINDING => ECO:0000269|PubMed:27434672, ECO:0007744|PDB:5K5S
ChainResidueDetails
AARG66
BASP234
BARG415
BGLY557
ATHR145
AGLU231
AASP234
AARG415
AGLY557
BARG66
BTHR145
BGLU231

site_idSWS_FT_FI11
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:27434672, ECO:0000305|PubMed:27386547, ECO:0007744|PDB:5FBH, ECO:0007744|PDB:5FBK, ECO:0007744|PDB:5K5S
ChainResidueDetails
AILE81
ALEU87
ALEU88
BILE81
BLEU87
BLEU88

site_idSWS_FT_FI12
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:27434672, ECO:0000305|PubMed:27386547, ECO:0007744|PDB:5FBK, ECO:0007744|PDB:5K5S
ChainResidueDetails
ASER84
BSER84

site_idSWS_FT_FI13
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:27434672, ECO:0007744|PDB:5K5S, ECO:0007744|PDB:5K5T
ChainResidueDetails
ATHR100
BTHR100

site_idSWS_FT_FI14
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:27386547, ECO:0000269|PubMed:27434672, ECO:0007744|PDB:5FBH, ECO:0007744|PDB:5FBK, ECO:0007744|PDB:5K5S
ChainResidueDetails
ASER147
AALA168
ASER170
AGLU297
BSER147
BALA168
BSER170
BGLU297

site_idSWS_FT_FI15
Number of Residues2
DetailsSITE: Important for ability of agonist AMG 416 to activate G-protein-coupled receptor activity => ECO:0000269|PubMed:26290606
ChainResidueDetails
ACYS482
BCYS482

site_idSWS_FT_FI16
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9QY96
ChainResidueDetails
ASER920
ASER1061
BSER920
BSER1061

site_idSWS_FT_FI17
Number of Residues8
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN90
AASN130
AASN386
AASN400
BASN90
BASN130
BASN386
BASN400

site_idSWS_FT_FI18
Number of Residues14
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:27434672
ChainResidueDetails
AASN261
BASN446
BASN468
BASN488
BASN541
BASN594
AASN287
AASN446
AASN468
AASN488
AASN541
AASN594
BASN261
BASN287

220113

PDB entries from 2024-05-22

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