7C2N

Crystal structure of mycolic acid transporter MmpL3 from Mycobacterium smegmatis complexed with SPIRO

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003796	molecular_function	lysozyme activity
A	0009253	biological_process	peptidoglycan catabolic process
A	0016020	cellular_component	membrane
A	0016998	biological_process	cell wall macromolecule catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue L6T A 1001

Chain	Residue
A	GLU46
A	PHE240
A	SER54
A	LEU55
A	ASP58
A	ARG63
A	ASP64
A	ASP144
A	LEU171
A	HIS239

---

site_id	AC2
Number of Residues	5
Details	binding site for residue L6T A 1002

Chain	Residue
A	VAL109
A	THR121
A	VAL122
A	MET125
A	ARG453

---

site_id	AC3
Number of Residues	9
Details	binding site for residue L6T A 1003

Chain	Residue
A	GLN-3
A	ARG288
A	VAL291
A	PHE292
A	LEU581
A	SER652
A	ARG653
A	GLU656
A	ARG744

---

site_id	AC4
Number of Residues	7
Details	binding site for residue L6T A 1004

Chain	Residue
A	TRP609
A	HIS615
A	GLY618
A	LEU619
A	LEU713
A	LYS884
A	MHA1007

---

site_id	AC5
Number of Residues	4
Details	binding site for residue L6T A 1005

Chain	Residue
A	ARG188
A	ALA192
A	ASN621
A	ALA692

---

site_id	AC6
Number of Residues	7
Details	binding site for residue MHA A 1006

Chain	Residue
A	ASP759
A	THR891
A	ASN893
A	ARG894
A	ILE917
A	LYS918
A	ALA919

---

site_id	AC7
Number of Residues	7
Details	binding site for residue MHA A 1007

Chain	Residue
A	GLY862
A	PHE863
A	THR864
A	ASN865
A	SER866
A	ASN881
A	L6T1004

---

site_id	AC8
Number of Residues	11
Details	binding site for residue FG0 A 1008

Chain	Residue
A	ILE249
A	ILE253
A	PHE260
A	SER293
A	ILE297
A	VAL638
A	GLY641
A	LEU642
A	ASP645
A	TYR646
A	PHE649

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	131
Details	TOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:30682372, ECO:0000305|PubMed:31113875

Chain	Residue	Details
A	MET1-TYR14
A	VAL262-VAL290
A	ALA339-PRO401
A	PRO589-LYS591
A	SER652-LEU678

---

site_id	SWS_FT_FI2
Number of Residues	240
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
A	ILE15-GLY35
A	VAL197-ILE217
A	GLY218-VAL238
A	PHE241-ILE261
A	VAL291-PHE311
A	ALA318-LEU338
A	ILE402-LEU422
A	ALA568-LEU588
A	ALA592-VAL612
A	MET631-VAL651
A	ILE679-VAL699
A	LEU704-VAL724

---

site_id	SWS_FT_FI3
Number of Residues	330
Details	TOPO_DOM: Periplasmic => ECO:0000305|PubMed:30682372, ECO:0000305|PubMed:31113875

Chain	Residue	Details
A	ASN36-LEU196
A	HIS239-PHE240
A	LEU312-TYR317
A	SER423-MET567
A	ASP613-PRO630
A	MET700-TYR703

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:31113875, ECO:0007744|PDB:6OR2

Chain	Residue	Details
A	GLN40

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:30682372, ECO:0007744|PDB:6AJG

Chain	Residue	Details
A	ASP645

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	SITE: Part of the proton-transportation channel => ECO:0000305|PubMed:30682372, ECO:0000305|PubMed:31113875

Chain	Residue	Details
A	TYR646
A	ASP256
A	TYR257

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	SITE: Part of the proton transportation network => ECO:0000305|PubMed:31113875

Chain	Residue	Details
A	GLU647
A	LYS591

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	SITE: Part of the proton-transportation channel => ECO:0000305|PubMed:30682372, ECO:0000305|PubMed:31113875, ECO:0000305|PubMed:32512002

Chain	Residue	Details
A	ASP645

---