7AR7

Cryo-EM structure of Arabidopsis thaliana complex-I (open conformation)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005739	cellular_component	mitochondrion
A	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
A	0016020	cellular_component	membrane
A	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
A	0030964	cellular_component	NADH dehydrogenase complex
A	0031966	cellular_component	mitochondrial membrane
A	0055085	biological_process	transmembrane transport
A	0070469	cellular_component	respirasome
B	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
B	0048038	molecular_function	quinone binding
B	0051536	molecular_function	iron-sulfur cluster binding
B	0051539	molecular_function	4 iron, 4 sulfur cluster binding
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0005747	cellular_component	mitochondrial respiratory chain complex I
C	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
C	0016491	molecular_function	oxidoreductase activity
C	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
C	0055085	biological_process	transmembrane transport
C	0070469	cellular_component	respirasome
D	0005739	cellular_component	mitochondrion
D	0005747	cellular_component	mitochondrial respiratory chain complex I
D	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
D	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
D	0016491	molecular_function	oxidoreductase activity
D	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
D	0048038	molecular_function	quinone binding
D	0051287	molecular_function	NAD binding
D	0055085	biological_process	transmembrane transport
D	0070469	cellular_component	respirasome
E	0016491	molecular_function	oxidoreductase activity
F	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
F	0010181	molecular_function	FMN binding
F	0051287	molecular_function	NAD binding
F	0051539	molecular_function	4 iron, 4 sulfur cluster binding
G	0005739	cellular_component	mitochondrion
G	0005743	cellular_component	mitochondrial inner membrane
G	0005747	cellular_component	mitochondrial respiratory chain complex I
G	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
G	0009507	cellular_component	chloroplast
G	0009536	cellular_component	plastid
G	0009853	biological_process	photorespiration
G	0016020	cellular_component	membrane
G	0016491	molecular_function	oxidoreductase activity
G	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
G	0031966	cellular_component	mitochondrial membrane
G	0042773	biological_process	ATP synthesis coupled electron transport
G	0045271	cellular_component	respiratory chain complex I
G	0046872	molecular_function	metal ion binding
G	0051536	molecular_function	iron-sulfur cluster binding
G	0051537	molecular_function	2 iron, 2 sulfur cluster binding
G	0051539	molecular_function	4 iron, 4 sulfur cluster binding
G	0055085	biological_process	transmembrane transport
G	0070469	cellular_component	respirasome
H	0003954	molecular_function	NADH dehydrogenase activity
H	0005739	cellular_component	mitochondrion
H	0005743	cellular_component	mitochondrial inner membrane
H	0005747	cellular_component	mitochondrial respiratory chain complex I
H	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
H	0009060	biological_process	aerobic respiration
H	0016020	cellular_component	membrane
H	0055085	biological_process	transmembrane transport
H	0070469	cellular_component	respirasome
I	0016020	cellular_component	membrane
I	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
I	0051539	molecular_function	4 iron, 4 sulfur cluster binding
J	0005739	cellular_component	mitochondrion
J	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
J	0016020	cellular_component	membrane
J	0031966	cellular_component	mitochondrial membrane
J	0055085	biological_process	transmembrane transport
J	0070469	cellular_component	respirasome
K	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
K	0042773	biological_process	ATP synthesis coupled electron transport
L	0003954	molecular_function	NADH dehydrogenase activity
L	0005739	cellular_component	mitochondrion
L	0005743	cellular_component	mitochondrial inner membrane
L	0005747	cellular_component	mitochondrial respiratory chain complex I
L	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
L	0009536	cellular_component	plastid
L	0015990	biological_process	electron transport coupled proton transport
L	0042773	biological_process	ATP synthesis coupled electron transport
L	0070469	cellular_component	respirasome
M	0003954	molecular_function	NADH dehydrogenase activity
M	0005739	cellular_component	mitochondrion
M	0005743	cellular_component	mitochondrial inner membrane
M	0005747	cellular_component	mitochondrial respiratory chain complex I
M	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
M	0009060	biological_process	aerobic respiration
M	0009536	cellular_component	plastid
M	0015990	biological_process	electron transport coupled proton transport
M	0042773	biological_process	ATP synthesis coupled electron transport
M	0048039	molecular_function	ubiquinone binding
M	0070469	cellular_component	respirasome
N	0005739	cellular_component	mitochondrion
N	0005743	cellular_component	mitochondrial inner membrane
N	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
N	0009536	cellular_component	plastid
N	0042773	biological_process	ATP synthesis coupled electron transport
N	0055085	biological_process	transmembrane transport
N	0070469	cellular_component	respirasome
Q	0022900	biological_process	electron transport chain
S	0005739	cellular_component	mitochondrion
S	0005743	cellular_component	mitochondrial inner membrane
S	0005747	cellular_component	mitochondrial respiratory chain complex I
S	0009536	cellular_component	plastid
S	0070469	cellular_component	respirasome
T	0006633	biological_process	fatty acid biosynthetic process
U	0006633	biological_process	fatty acid biosynthetic process
V	0022904	biological_process	respiratory electron transport chain
W	0005739	cellular_component	mitochondrion
W	0005743	cellular_component	mitochondrial inner membrane
W	0005747	cellular_component	mitochondrial respiratory chain complex I
W	0005829	cellular_component	cytosol
W	0070469	cellular_component	respirasome
X	0005739	cellular_component	mitochondrion
X	0005747	cellular_component	mitochondrial respiratory chain complex I
X	0005758	cellular_component	mitochondrial intermembrane space
X	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
X	0009536	cellular_component	plastid
X	0070469	cellular_component	respirasome
d	0000325	cellular_component	plant-type vacuole
d	0005739	cellular_component	mitochondrion
d	0005747	cellular_component	mitochondrial respiratory chain complex I
d	0005829	cellular_component	cytosol
f	0005739	cellular_component	mitochondrion
f	0005747	cellular_component	mitochondrial respiratory chain complex I
f	0005829	cellular_component	cytosol
f	0009853	biological_process	photorespiration
f	0031966	cellular_component	mitochondrial membrane
f	0045271	cellular_component	respiratory chain complex I
j	0005743	cellular_component	mitochondrial inner membrane
j	0005747	cellular_component	mitochondrial respiratory chain complex I
k	0005739	cellular_component	mitochondrion
k	0022900	biological_process	electron transport chain
m	0005739	cellular_component	mitochondrion
m	0005747	cellular_component	mitochondrial respiratory chain complex I
m	0009853	biological_process	photorespiration
m	0016020	cellular_component	membrane
m	0031966	cellular_component	mitochondrial membrane
m	0045271	cellular_component	respiratory chain complex I
n	0000325	cellular_component	plant-type vacuole
n	0005739	cellular_component	mitochondrion
n	0005743	cellular_component	mitochondrial inner membrane
n	0005886	cellular_component	plasma membrane
n	0005975	biological_process	carbohydrate metabolic process
n	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
n	0009853	biological_process	photorespiration
n	0031966	cellular_component	mitochondrial membrane
n	0045271	cellular_component	respiratory chain complex I
n	0070469	cellular_component	respirasome
o	0005739	cellular_component	mitochondrion
q	0016020	cellular_component	membrane
q	0032981	biological_process	mitochondrial respiratory chain complex I assembly
y	0004089	molecular_function	carbonate dehydratase activity
y	0005515	molecular_function	protein binding
y	0005634	cellular_component	nucleus
y	0005737	cellular_component	cytoplasm
y	0005739	cellular_component	mitochondrion
y	0005747	cellular_component	mitochondrial respiratory chain complex I
y	0009853	biological_process	photorespiration
y	0009901	biological_process	anther dehiscence
y	0016020	cellular_component	membrane
y	0016829	molecular_function	lyase activity
y	0031966	cellular_component	mitochondrial membrane
y	0042802	molecular_function	identical protein binding
y	0045271	cellular_component	respiratory chain complex I
y	0046872	molecular_function	metal ion binding
y	0070207	biological_process	protein homotrimerization
y	2000377	biological_process	regulation of reactive oxygen species metabolic process

Functional Information from PROSITE/UniProt

site_id	PS01150
Number of Residues	17
Details	COMPLEX1_20K Respiratory-chain NADH dehydrogenase 20 Kd subunit signature. GcDRIVPVDIYvPgCPP

Chain	Residue	Details
B	GLY174-PRO190

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site_id	PS00641
Number of Residues	18
Details	COMPLEX1_75K_1 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 1. PrfCYhsrlsiaGnCRmC

Chain	Residue	Details
G	PRO103-CYS120

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site_id	PS00642
Number of Residues	13
Details	COMPLEX1_75K_2 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 2. CPiCDqGGeCdLQ

Chain	Residue	Details
G	CYS170-GLN182

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site_id	PS00643
Number of Residues	11
Details	COMPLEX1_75K_3 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 3. RCIqCtRCVrF

Chain	Residue	Details
G	ARG217-PHE227

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site_id	PS01099
Number of Residues	19
Details	COMPLEX1_24K Respiratory-chain NADH dehydrogenase 24 Kd subunit signature. DglFSvgemeCMGcCvnAP

Chain	Residue	Details
E	ASP161-PRO179

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site_id	PS00667
Number of Residues	16
Details	COMPLEX1_ND1_1 Respiratory-chain NADH dehydrogenase subunit 1 signature 1. GLLQpLaDGLKLIlKE

Chain	Residue	Details
H	GLY47-GLU62

---

site_id	PS00668
Number of Residues	14
Details	COMPLEX1_ND1_2 Respiratory-chain NADH dehydrogenase subunit 1 signature 2. PFDLPEAEaeLVa.G

Chain	Residue	Details
H	PRO202-GLY215

---

site_id	PS00535
Number of Residues	12
Details	COMPLEX1_49K Respiratory chain NADH dehydrogenase 49 Kd subunit signature. LHRGtEKLiEyK

Chain	Residue	Details
D	LEU47-LYS58

---

site_id	PS00542
Number of Residues	22
Details	COMPLEX1_30K Respiratory chain NADH dehydrogenase 30 Kd subunit signature. EREvwDMFgvsfinHpdlRrIL

Chain	Residue	Details
C	GLU112-LEU133

---

site_id	PS00644
Number of Residues	16
Details	COMPLEX1_51K_1 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 1. GAGAYICGEETALLES

Chain	Residue	Details
F	GLY223-SER238

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site_id	PS00645
Number of Residues	12
Details	COMPLEX1_51K_2 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. ESCGqCtPCReG

Chain	Residue	Details
F	GLU400-GLY411

---

site_id	PS00198
Number of Residues	12
Details	4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CiACKlCEaVCP

Chain	Residue	Details
I	CYS123-PRO134
I	CYS162-PRO173

---

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. DLGLDSLDSVEVVMAL

Chain	Residue	Details
U	ASP78-LEU93
T	ASP74-ILE89

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
N	LEU319-ILE339
N	LEU345-ALA365
N	ILE386-GLY406
N	PHE411-VAL431
N	LEU467-PHE487
N	ILE293-THR313
I	CYS162
I	CYS165
I	CYS168
I	CYS123
I	CYS126
I	CYS129
I	CYS133
I	CYS172

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01184

Chain	Residue	Details
G	CYS179
G	HIS166
G	CYS170
G	CYS173

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