6W6O
NaChBac-Nav1.7VSDII chimera and HWTX-IV complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005261 | molecular_function | monoatomic cation channel activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0055085 | biological_process | transmembrane transport |
| C | 0005576 | cellular_component | extracellular region |
| C | 0008200 | molecular_function | ion channel inhibitor activity |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0005261 | molecular_function | monoatomic cation channel activity |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0016020 | cellular_component | membrane |
| D | 0055085 | biological_process | transmembrane transport |
| E | 0005576 | cellular_component | extracellular region |
| E | 0008200 | molecular_function | ion channel inhibitor activity |
| F | 0005216 | molecular_function | monoatomic ion channel activity |
| F | 0005261 | molecular_function | monoatomic cation channel activity |
| F | 0005886 | cellular_component | plasma membrane |
| F | 0006811 | biological_process | monoatomic ion transport |
| F | 0016020 | cellular_component | membrane |
| F | 0055085 | biological_process | transmembrane transport |
| G | 0005576 | cellular_component | extracellular region |
| G | 0008200 | molecular_function | ion channel inhibitor activity |
| H | 0005216 | molecular_function | monoatomic ion channel activity |
| H | 0005261 | molecular_function | monoatomic cation channel activity |
| H | 0005886 | cellular_component | plasma membrane |
| H | 0006811 | biological_process | monoatomic ion transport |
| H | 0016020 | cellular_component | membrane |
| H | 0055085 | biological_process | transmembrane transport |
| I | 0005576 | cellular_component | extracellular region |
| I | 0008200 | molecular_function | ion channel inhibitor activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue POV A 301 |
| Chain | Residue |
| A | PHE205 |
| A | ALA206 |
| A | TRP210 |
| A | TRP212 |
| F | POV301 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue POV A 302 |
| Chain | Residue |
| A | TRP210 |
| A | SER211 |
| H | SER113 |
| A | PHE157 |
| A | PHE161 |
| A | LEU168 |
| A | VAL208 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue POV A 303 |
| Chain | Residue |
| A | LEU34 |
| A | ILE48 |
| D | ILE156 |
| D | LEU184 |
| F | POV302 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue POV D 301 |
| Chain | Residue |
| D | PHE205 |
| D | ALA206 |
| D | TRP210 |
| D | TRP212 |
| H | POV301 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue POV D 302 |
| Chain | Residue |
| A | SER113 |
| D | PHE157 |
| D | PHE161 |
| D | LEU168 |
| D | VAL208 |
| D | TRP210 |
| D | SER211 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue POV D 303 |
| Chain | Residue |
| D | LEU34 |
| D | ILE48 |
| F | ILE156 |
| F | LEU184 |
| H | POV302 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue POV F 301 |
| Chain | Residue |
| A | POV301 |
| F | LEU34 |
| F | ILE48 |
| H | ILE156 |
| H | LEU184 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue POV F 302 |
| Chain | Residue |
| A | POV303 |
| F | PHE205 |
| F | ALA206 |
| F | TRP210 |
| F | TRP212 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for residue POV F 303 |
| Chain | Residue |
| D | SER113 |
| F | PHE157 |
| F | PHE161 |
| F | LEU168 |
| F | VAL208 |
| F | TRP210 |
| F | SER211 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue POV H 301 |
| Chain | Residue |
| A | ILE156 |
| A | LEU184 |
| D | POV301 |
| H | LEU34 |
| H | ILE48 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue POV H 302 |
| Chain | Residue |
| D | POV303 |
| H | PHE205 |
| H | ALA206 |
| H | TRP210 |
| H | TRP212 |
| site_id | AD3 |
| Number of Residues | 7 |
| Details | binding site for residue POV H 303 |
| Chain | Residue |
| F | SER113 |
| H | PHE157 |
| H | PHE161 |
| H | LEU168 |
| H | VAL208 |
| H | TRP210 |
| H | SER211 |
Functional Information from PROSITE/UniProt
| site_id | PS60021 |
| Number of Residues | 30 |
| Details | HWTX_1 Huwentoxin-1 family signature. CLeIfkaCnpsndqCCkssklvCsrktRWC |
| Chain | Residue | Details |
| C | CYS2-CYS31 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 20 |
| Details | SITE: Binds to the extracellular loop of voltage sensor domain II of sodium channels (Nav1.2/SCN2A and Nav1.7/SCN9A) => ECO:0000305|PubMed:23760503 |
| Chain | Residue | Details |
| E | PHE6 | |
| E | ARG26 | |
| E | LYS27 | |
| E | TRP30 | |
| E | LYS32 | |
| G | PHE6 | |
| G | ARG26 | |
| G | LYS27 | |
| G | TRP30 | |
| G | LYS32 | |
| I | PHE6 | |
| I | ARG26 | |
| I | LYS27 | |
| I | TRP30 | |
| I | LYS32 | |
| C | ARG26 | |
| C | PHE6 | |
| C | LYS27 | |
| C | TRP30 | |
| C | LYS32 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | MOD_RES: Pyrrolidone carboxylic acid (Glu); partial => ECO:0000269|PubMed:23826086 |
| Chain | Residue | Details |
| G | GLU1 | |
| I | GLU1 | |
| F | GLU103 | |
| F | ASP108 | |
| H | GLU103 | |
| H | ASP108 | |
| C | GLU1 | |
| E | GLU1 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | MOD_RES: Isoleucine amide => ECO:0000269|PubMed:12228241 |
| Chain | Residue | Details |
| E | ILE35 | |
| G | ILE35 | |
| I | ILE35 | |
| C | ILE35 |
