6UPA
Crystal Structure of GTPase Domain of Human Septin 2/Septin 6 Heterocomplex
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 23 |
| Details | binding site for residue GTP B 401 |
| Chain | Residue |
| A | HIS158 |
| B | THR57 |
| B | PRO71 |
| B | ALA72 |
| B | LYS185 |
| B | ASP187 |
| B | ILE238 |
| B | GLY239 |
| B | ARG254 |
| B | TYR256 |
| B | MG402 |
| A | THR186 |
| B | HOH505 |
| B | HOH507 |
| B | HOH508 |
| B | HOH511 |
| A | GLU191 |
| B | THR51 |
| B | GLY52 |
| B | LEU53 |
| B | GLY54 |
| B | LYS55 |
| B | SER56 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 402 |
| Chain | Residue |
| B | SER56 |
| B | GTP401 |
| B | HOH507 |
| B | HOH508 |
| B | HOH511 |
| site_id | AC3 |
| Number of Residues | 18 |
| Details | binding site for residue GDP A 1401 |
| Chain | Residue |
| A | SER46 |
| A | GLY47 |
| A | LEU48 |
| A | GLY49 |
| A | LYS50 |
| A | SER51 |
| A | THR52 |
| A | ARG66 |
| A | LYS183 |
| A | ASP185 |
| A | VAL240 |
| A | GLY241 |
| A | ARG256 |
| A | TYR258 |
| B | THR158 |
| B | HIS160 |
| B | ALA188 |
| B | GLU193 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | GLY241 | |
| A | ARG256 | |
| A | GLY44 | |
| A | LYS183 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | GLY104 | |
| B | ARG254 | |
| A | THR78 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | SITE: Important for dimerization |
| Chain | Residue | Details |
| A | PHE156 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS190 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | TYR211 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:15150837, ECO:0000269|PubMed:19165576, ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18088087, ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:18318008, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER218 |
