6UM2

Structure of M-6-P/IGFII Receptor and IGFII complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005537	molecular_function	mannose binding
A	0007041	biological_process	lysosomal transport
A	0038023	molecular_function	signaling receptor activity
B	0005179	molecular_function	hormone activity
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0008083	molecular_function	growth factor activity

Functional Information from PROSITE/UniProt

site_id	PS00023
Number of Residues	40
Details	FN2_1 Fibronectin type-II collagen-binding domain signature. CvfPFvFngksyeeCvvesrarl..WCattaNYdrdheWgFC

Chain	Residue	Details
A	CYS1912-CYS1951

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site_id	PS00262
Number of Residues	15
Details	INSULIN Insulin family signature. CCFRsCDlalLetyC

Chain	Residue	Details
B	CYS46-CYS60

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	SITE: Important for interaction with integrin => ECO:0000269|PubMed:28873464

Chain	Residue	Details
B	ARG24
B	ARG34
B	ARG37
B	ARG38

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site_id	SWS_FT_FI2
Number of Residues	22
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
A	ALA2314-TYR2336

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site_id	SWS_FT_FI3
Number of Residues	162
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
A	LYS2337-VAL2499

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P11717

Chain	Residue	Details
A	LYS2361

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site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P11717

Chain	Residue	Details
A	SER2421
A	SER2492

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site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Omega-N-methylarginine => ECO:0000250|UniProtKB:Q07113

Chain	Residue	Details
A	ARG2438

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site_id	SWS_FT_FI7
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15085180

Chain	Residue	Details
A	ASN120
A	ASN409

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site_id	SWS_FT_FI8
Number of Residues	17
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN444
A	ASN552
A	ASN590
A	ASN635
A	ASN755
A	ASN879
A	ASN959
A	ASN1030
A	ASN1173
A	ASN1255
A	ASN1321
A	ASN1665
A	ASN1766
A	ASN1825
A	ASN2094
A	ASN2145
A	ASN2220

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