6T36
Crystal structure of the PTPN3 PDZ domain bound to the HBV core protein C-terminal peptide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000165 | biological_process | MAPK cascade |
| A | 0001784 | molecular_function | phosphotyrosine residue binding |
| A | 0004721 | molecular_function | phosphoprotein phosphatase activity |
| A | 0004725 | molecular_function | protein tyrosine phosphatase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005856 | cellular_component | cytoskeleton |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006470 | biological_process | protein dephosphorylation |
| A | 0008092 | molecular_function | cytoskeletal protein binding |
| A | 0009898 | cellular_component | cytoplasmic side of plasma membrane |
| A | 0016311 | biological_process | dephosphorylation |
| A | 0017080 | molecular_function | sodium channel regulator activity |
| A | 0042059 | biological_process | negative regulation of epidermal growth factor receptor signaling pathway |
| A | 0045930 | biological_process | negative regulation of mitotic cell cycle |
| A | 0051045 | biological_process | negative regulation of membrane protein ectodomain proteolysis |
| A | 0051117 | molecular_function | ATPase binding |
| A | 0097421 | biological_process | liver regeneration |
| A | 0098902 | biological_process | regulation of membrane depolarization during action potential |
| A | 2000649 | biological_process | regulation of sodium ion transmembrane transporter activity |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003723 | molecular_function | RNA binding |
| B | 0005198 | molecular_function | structural molecule activity |
| B | 0005576 | cellular_component | extracellular region |
| B | 0019049 | biological_process | virus-mediated perturbation of host defense response |
| B | 0030430 | cellular_component | host cell cytoplasm |
| B | 0039619 | cellular_component | T=4 icosahedral viral capsid |
| B | 0043657 | cellular_component | host cell |
| B | 0046718 | biological_process | symbiont entry into host cell |
| B | 0075521 | biological_process | microtubule-dependent intracellular transport of viral material towards nucleus |
| B | 0075732 | biological_process | viral penetration into host nucleus |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 1 |
| Details | binding site for residue BR A 1001 |
| Chain | Residue |
| A | LYS552 |
Functional Information from PROSITE/UniProt
| site_id | PS00383 |
| Number of Residues | 11 |
| Details | TYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. VHCsaGigRTG |
| Chain | Residue | Details |
| A | VAL840-GLY850 |
| site_id | PS00660 |
| Number of Residues | 30 |
| Details | FERM_1 FERM domain signature 1. WLeasKaIrkQ..Lkggfpct.LhfrvrFFipD |
| Chain | Residue | Details |
| A | TRP84-ASP113 |
| site_id | PS00661 |
| Number of Residues | 30 |
| Details | FERM_2 FERM domain signature 2. HeqhsglkqsEAescYIni.ArtLdfYGvEL |
| Chain | Residue | Details |
| A | HIS192-LEU221 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Phosphocysteine intermediate => ECO:0000255|PROSITE-ProRule:PRU00160, ECO:0000255|PROSITE-ProRule:PRU10044 |
| Chain | Residue | Details |
| A | CYS842 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | GLN886 | |
| A | ASP811 | |
| A | CYS842 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER357 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER359 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648 |
| Chain | Residue | Details |
| A | SER367 | |
| A | SER381 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648 |
| Chain | Residue | Details |
| A | THR376 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER425 |
