6SBO
Estrogen receptor mutant L536S
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | binding site for residue L5B A 4000 |
| Chain | Residue |
| A | MET343 |
| A | ARG394 |
| A | MET421 |
| A | GLY521 |
| A | HIS524 |
| A | LEU525 |
| A | VAL533 |
| A | VAL534 |
| A | PRO535 |
| A | LEU539 |
| A | HOH4118 |
| A | LEU346 |
| A | THR347 |
| A | LEU349 |
| A | ALA350 |
| A | ASP351 |
| A | GLU353 |
| A | TRP383 |
| A | LEU387 |
| site_id | AC2 |
| Number of Residues | 22 |
| Details | binding site for residue L5B B 4000 |
| Chain | Residue |
| B | MET343 |
| B | LEU346 |
| B | THR347 |
| B | LEU349 |
| B | ALA350 |
| B | ASP351 |
| B | GLU353 |
| B | LEU354 |
| B | LEU387 |
| B | ARG394 |
| B | MET421 |
| B | ILE424 |
| B | GLY521 |
| B | HIS524 |
| B | LEU525 |
| B | MET528 |
| B | ASN532 |
| B | VAL533 |
| B | VAL534 |
| B | PRO535 |
| B | LEU539 |
| B | HOH4120 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 130 |
| Details | DNA_BIND: Nuclear receptor => ECO:0000255|PROSITE-ProRule:PRU00407 |
| Chain | Residue | Details |
| A | ILE358-GLU423 | |
| B | ILE358-GLU423 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 88 |
| Details | ZN_FING: NR C4-type => ECO:0000255|PROSITE-ProRule:PRU00407 |
| Chain | Residue | Details |
| A | ILE358-LEU378 | |
| A | ARG394-VAL418 | |
| B | ILE358-LEU378 | |
| B | ARG394-VAL418 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by CK2 => ECO:0000269|PubMed:7838153 |
| Chain | Residue | Details |
| B | ALA340 | |
| A | ALA340 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Asymmetric dimethylarginine; by PRMT1 => ECO:0000269|PubMed:18657504, ECO:0000269|PubMed:24498420 |
| Chain | Residue | Details |
| B | SER433 | |
| A | SER433 |
