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6SB2

cryo-EM structure of mTORC1 bound to active RagA/C GTPases

Functional Information from GO Data
ChainGOidnamespacecontents
A0000139cellular_componentGolgi membrane
A0001002molecular_functionRNA polymerase III type 1 promoter sequence-specific DNA binding
A0001003molecular_functionRNA polymerase III type 2 promoter sequence-specific DNA binding
A0001006molecular_functionRNA polymerase III type 3 promoter sequence-specific DNA binding
A0001156molecular_functionTFIIIC-class transcription factor complex binding
A0001558biological_processregulation of cell growth
A0001932biological_processregulation of protein phosphorylation
A0001934biological_processpositive regulation of protein phosphorylation
A0002296biological_processT-helper 1 cell lineage commitment
A0003007biological_processheart morphogenesis
A0003179biological_processheart valve morphogenesis
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005635cellular_componentnuclear envelope
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005741cellular_componentmitochondrial outer membrane
A0005764cellular_componentlysosome
A0005765cellular_componentlysosomal membrane
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0006112biological_processenergy reserve metabolic process
A0006207biological_process'de novo' pyrimidine nucleobase biosynthetic process
A0006468biological_processprotein phosphorylation
A0006954biological_processinflammatory response
A0006974biological_processDNA damage response
A0007010biological_processcytoskeleton organization
A0007040biological_processlysosome organization
A0007281biological_processgerm cell development
A0007584biological_processresponse to nutrient
A0008361biological_processregulation of cell size
A0009267biological_processcellular response to starvation
A0009408biological_processresponse to heat
A0009791biological_processpost-embryonic development
A0010506biological_processregulation of autophagy
A0010507biological_processnegative regulation of autophagy
A0010592biological_processpositive regulation of lamellipodium assembly
A0010628biological_processpositive regulation of gene expression
A0010718biological_processpositive regulation of epithelial to mesenchymal transition
A0010831biological_processpositive regulation of myotube differentiation
A0012505cellular_componentendomembrane system
A0016020cellular_componentmembrane
A0016236biological_processmacroautophagy
A0016241biological_processregulation of macroautophagy
A0016242biological_processnegative regulation of macroautophagy
A0016301molecular_functionkinase activity
A0016310biological_processphosphorylation
A0016605cellular_componentPML body
A0018105biological_processpeptidyl-serine phosphorylation
A0019228biological_processneuronal action potential
A0030030biological_processcell projection organization
A0030163biological_processprotein catabolic process
A0030307biological_processpositive regulation of cell growth
A0030425cellular_componentdendrite
A0030838biological_processpositive regulation of actin filament polymerization
A0031295biological_processT cell costimulation
A0031410cellular_componentcytoplasmic vesicle
A0031529biological_processruffle organization
A0031641biological_processregulation of myelination
A0031648biological_processprotein destabilization
A0031667biological_processresponse to nutrient levels
A0031669biological_processcellular response to nutrient levels
A0031670biological_processcellular response to nutrient
A0031929biological_processTOR signaling
A0031931cellular_componentTORC1 complex
A0031932cellular_componentTORC2 complex
A0032516biological_processpositive regulation of phosphoprotein phosphatase activity
A0032868biological_processresponse to insulin
A0032869biological_processcellular response to insulin stimulus
A0032956biological_processregulation of actin cytoskeleton organization
A0033173biological_processcalcineurin-NFAT signaling cascade
A0034198biological_processcellular response to amino acid starvation
A0035264biological_processmulticellular organism growth
A0038202biological_processTORC1 signaling
A0042752biological_processregulation of circadian rhythm
A0042802molecular_functionidentical protein binding
A0043022molecular_functionribosome binding
A0043066biological_processnegative regulation of apoptotic process
A0043200biological_processresponse to amino acid
A0043276biological_processanoikis
A0044877molecular_functionprotein-containing complex binding
A0045335cellular_componentphagocytic vesicle
A0045670biological_processregulation of osteoclast differentiation
A0045727biological_processpositive regulation of translation
A0045792biological_processnegative regulation of cell size
A0045821biological_processpositive regulation of glycolytic process
A0045945biological_processpositive regulation of transcription by RNA polymerase III
A0045948biological_processpositive regulation of translational initiation
A0046777biological_processprotein autophosphorylation
A0046889biological_processpositive regulation of lipid biosynthetic process
A0048266biological_processbehavioral response to pain
A0048511biological_processrhythmic process
A0048709biological_processoligodendrocyte differentiation
A0048714biological_processpositive regulation of oligodendrocyte differentiation
A0048738biological_processcardiac muscle tissue development
A0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
A0050882biological_processvoluntary musculoskeletal movement
A0051128biological_processregulation of cellular component organization
A0051219molecular_functionphosphoprotein binding
A0051247biological_processpositive regulation of protein metabolic process
A0051496biological_processpositive regulation of stress fiber assembly
A0051549biological_processpositive regulation of keratinocyte migration
A0051647biological_processnucleus localization
A0051896biological_processregulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0055006biological_processcardiac cell development
A0055013biological_processcardiac muscle cell development
A0060048biological_processcardiac muscle contraction
A0061431biological_processcellular response to methionine
A0070885biological_processnegative regulation of calcineurin-NFAT signaling cascade
A0071230biological_processcellular response to amino acid stimulus
A0071233biological_processcellular response to L-leucine
A0071456biological_processcellular response to hypoxia
A0071470biological_processcellular response to osmotic stress
A0080135biological_processregulation of cellular response to stress
A0090559biological_processregulation of membrane permeability
A0106310molecular_functionprotein serine kinase activity
A1900034biological_processregulation of cellular response to heat
A1900181biological_processnegative regulation of protein localization to nucleus
A1901796biological_processregulation of signal transduction by p53 class mediator
A1901838biological_processpositive regulation of transcription of nucleolar large rRNA by RNA polymerase I
A1903691biological_processpositive regulation of wound healing, spreading of epidermal cells
A1904059biological_processregulation of locomotor rhythm
A1904690biological_processpositive regulation of cytoplasmic translational initiation
A1905672biological_processnegative regulation of lysosome organization
A1905857biological_processpositive regulation of pentose-phosphate shunt
A1990253biological_processcellular response to leucine starvation
A2000785biological_processregulation of autophagosome assembly
B0000139cellular_componentGolgi membrane
B0001002molecular_functionRNA polymerase III type 1 promoter sequence-specific DNA binding
B0001003molecular_functionRNA polymerase III type 2 promoter sequence-specific DNA binding
B0001006molecular_functionRNA polymerase III type 3 promoter sequence-specific DNA binding
B0001156molecular_functionTFIIIC-class transcription factor complex binding
B0001558biological_processregulation of cell growth
B0001932biological_processregulation of protein phosphorylation
B0001934biological_processpositive regulation of protein phosphorylation
B0002296biological_processT-helper 1 cell lineage commitment
B0003007biological_processheart morphogenesis
B0003179biological_processheart valve morphogenesis
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005635cellular_componentnuclear envelope
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005741cellular_componentmitochondrial outer membrane
B0005764cellular_componentlysosome
B0005765cellular_componentlysosomal membrane
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0006112biological_processenergy reserve metabolic process
B0006207biological_process'de novo' pyrimidine nucleobase biosynthetic process
B0006468biological_processprotein phosphorylation
B0006954biological_processinflammatory response
B0006974biological_processDNA damage response
B0007010biological_processcytoskeleton organization
B0007040biological_processlysosome organization
B0007281biological_processgerm cell development
B0007584biological_processresponse to nutrient
B0008361biological_processregulation of cell size
B0009267biological_processcellular response to starvation
B0009408biological_processresponse to heat
B0009791biological_processpost-embryonic development
B0010506biological_processregulation of autophagy
B0010507biological_processnegative regulation of autophagy
B0010592biological_processpositive regulation of lamellipodium assembly
B0010628biological_processpositive regulation of gene expression
B0010718biological_processpositive regulation of epithelial to mesenchymal transition
B0010831biological_processpositive regulation of myotube differentiation
B0012505cellular_componentendomembrane system
B0016020cellular_componentmembrane
B0016236biological_processmacroautophagy
B0016241biological_processregulation of macroautophagy
B0016242biological_processnegative regulation of macroautophagy
B0016301molecular_functionkinase activity
B0016310biological_processphosphorylation
B0016605cellular_componentPML body
B0018105biological_processpeptidyl-serine phosphorylation
B0019228biological_processneuronal action potential
B0030030biological_processcell projection organization
B0030163biological_processprotein catabolic process
B0030307biological_processpositive regulation of cell growth
B0030425cellular_componentdendrite
B0030838biological_processpositive regulation of actin filament polymerization
B0031295biological_processT cell costimulation
B0031410cellular_componentcytoplasmic vesicle
B0031529biological_processruffle organization
B0031641biological_processregulation of myelination
B0031648biological_processprotein destabilization
B0031667biological_processresponse to nutrient levels
B0031669biological_processcellular response to nutrient levels
B0031670biological_processcellular response to nutrient
B0031929biological_processTOR signaling
B0031931cellular_componentTORC1 complex
B0031932cellular_componentTORC2 complex
B0032516biological_processpositive regulation of phosphoprotein phosphatase activity
B0032868biological_processresponse to insulin
B0032869biological_processcellular response to insulin stimulus
B0032956biological_processregulation of actin cytoskeleton organization
B0033173biological_processcalcineurin-NFAT signaling cascade
B0034198biological_processcellular response to amino acid starvation
B0035264biological_processmulticellular organism growth
B0038202biological_processTORC1 signaling
B0042752biological_processregulation of circadian rhythm
B0042802molecular_functionidentical protein binding
B0043022molecular_functionribosome binding
B0043066biological_processnegative regulation of apoptotic process
B0043200biological_processresponse to amino acid
B0043276biological_processanoikis
B0044877molecular_functionprotein-containing complex binding
B0045335cellular_componentphagocytic vesicle
B0045670biological_processregulation of osteoclast differentiation
B0045727biological_processpositive regulation of translation
B0045792biological_processnegative regulation of cell size
B0045821biological_processpositive regulation of glycolytic process
B0045945biological_processpositive regulation of transcription by RNA polymerase III
B0045948biological_processpositive regulation of translational initiation
B0046777biological_processprotein autophosphorylation
B0046889biological_processpositive regulation of lipid biosynthetic process
B0048266biological_processbehavioral response to pain
B0048511biological_processrhythmic process
B0048709biological_processoligodendrocyte differentiation
B0048714biological_processpositive regulation of oligodendrocyte differentiation
B0048738biological_processcardiac muscle tissue development
B0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
B0050882biological_processvoluntary musculoskeletal movement
B0051128biological_processregulation of cellular component organization
B0051219molecular_functionphosphoprotein binding
B0051247biological_processpositive regulation of protein metabolic process
B0051496biological_processpositive regulation of stress fiber assembly
B0051549biological_processpositive regulation of keratinocyte migration
B0051647biological_processnucleus localization
B0051896biological_processregulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B0055006biological_processcardiac cell development
B0055013biological_processcardiac muscle cell development
B0060048biological_processcardiac muscle contraction
B0061431biological_processcellular response to methionine
B0070885biological_processnegative regulation of calcineurin-NFAT signaling cascade
B0071230biological_processcellular response to amino acid stimulus
B0071233biological_processcellular response to L-leucine
B0071456biological_processcellular response to hypoxia
B0071470biological_processcellular response to osmotic stress
B0080135biological_processregulation of cellular response to stress
B0090559biological_processregulation of membrane permeability
B0106310molecular_functionprotein serine kinase activity
B1900034biological_processregulation of cellular response to heat
B1900181biological_processnegative regulation of protein localization to nucleus
B1901796biological_processregulation of signal transduction by p53 class mediator
B1901838biological_processpositive regulation of transcription of nucleolar large rRNA by RNA polymerase I
B1903691biological_processpositive regulation of wound healing, spreading of epidermal cells
B1904059biological_processregulation of locomotor rhythm
B1904690biological_processpositive regulation of cytoplasmic translational initiation
B1905672biological_processnegative regulation of lysosome organization
B1905857biological_processpositive regulation of pentose-phosphate shunt
B1990253biological_processcellular response to leucine starvation
B2000785biological_processregulation of autophagosome assembly
C0003924molecular_functionGTPase activity
C0005515molecular_functionprotein binding
C0005525molecular_functionGTP binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005764cellular_componentlysosome
C0005765cellular_componentlysosomal membrane
C0005829cellular_componentcytosol
C0006915biological_processapoptotic process
C0008104biological_processprotein localization
C0009267biological_processcellular response to starvation
C0010507biological_processnegative regulation of autophagy
C0016020cellular_componentmembrane
C0016787molecular_functionhydrolase activity
C0031625molecular_functionubiquitin protein ligase binding
C0031669biological_processcellular response to nutrient levels
C0032008biological_processpositive regulation of TOR signaling
C0033209biological_processtumor necrosis factor-mediated signaling pathway
C0034198biological_processcellular response to amino acid starvation
C0035556biological_processintracellular signal transduction
C0042593biological_processglucose homeostasis
C0042803molecular_functionprotein homodimerization activity
C0043495molecular_functionprotein-membrane adaptor activity
C0046982molecular_functionprotein heterodimerization activity
C0051219molecular_functionphosphoprotein binding
C0061462biological_processprotein localization to lysosome
C0071230biological_processcellular response to amino acid stimulus
C0072657biological_processprotein localization to membrane
C1904263biological_processpositive regulation of TORC1 signaling
C1990130cellular_componentGATOR1 complex
C1990131cellular_componentGtr1-Gtr2 GTPase complex
C1990877cellular_componentFNIP-folliculin RagC/D GAP
D0000287molecular_functionmagnesium ion binding
D0003924molecular_functionGTPase activity
D0005515molecular_functionprotein binding
D0005525molecular_functionGTP binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005764cellular_componentlysosome
D0005765cellular_componentlysosomal membrane
D0005829cellular_componentcytosol
D0006351biological_processDNA-templated transcription
D0006915biological_processapoptotic process
D0007264biological_processsmall GTPase-mediated signal transduction
D0008104biological_processprotein localization
D0008380biological_processRNA splicing
D0009267biological_processcellular response to starvation
D0010507biological_processnegative regulation of autophagy
D0016020cellular_componentmembrane
D0016787molecular_functionhydrolase activity
D0019003molecular_functionGDP binding
D0031669biological_processcellular response to nutrient levels
D0032006biological_processregulation of TOR signaling
D0034198biological_processcellular response to amino acid starvation
D0043200biological_processresponse to amino acid
D0043231cellular_componentintracellular membrane-bounded organelle
D0043495molecular_functionprotein-membrane adaptor activity
D0046982molecular_functionprotein heterodimerization activity
D0051020molecular_functionGTPase binding
D0060090molecular_functionmolecular adaptor activity
D0061462biological_processprotein localization to lysosome
D0071230biological_processcellular response to amino acid stimulus
D0072657biological_processprotein localization to membrane
D0140767molecular_functionenzyme-substrate adaptor activity
D1903432biological_processregulation of TORC1 signaling
D1904263biological_processpositive regulation of TORC1 signaling
D1990131cellular_componentGtr1-Gtr2 GTPase complex
D1990877cellular_componentFNIP-folliculin RagC/D GAP
E0005515molecular_functionprotein binding
E0005654cellular_componentnucleoplasm
E0005737cellular_componentcytoplasm
E0005764cellular_componentlysosome
E0005765cellular_componentlysosomal membrane
E0005829cellular_componentcytosol
E0006974biological_processDNA damage response
E0007010biological_processcytoskeleton organization
E0010507biological_processnegative regulation of autophagy
E0016020cellular_componentmembrane
E0030307biological_processpositive regulation of cell growth
E0030838biological_processpositive regulation of actin filament polymerization
E0031669biological_processcellular response to nutrient levels
E0031929biological_processTOR signaling
E0031931cellular_componentTORC1 complex
E0031932cellular_componentTORC2 complex
E0032008biological_processpositive regulation of TOR signaling
E0032956biological_processregulation of actin cytoskeleton organization
E0038202biological_processTORC1 signaling
E0043066biological_processnegative regulation of apoptotic process
E0043539molecular_functionprotein serine/threonine kinase activator activity
E0045821biological_processpositive regulation of glycolytic process
E0046889biological_processpositive regulation of lipid biosynthetic process
E0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
E0071456biological_processcellular response to hypoxia
E0071470biological_processcellular response to osmotic stress
E1905857biological_processpositive regulation of pentose-phosphate shunt
H0005515molecular_functionprotein binding
H0005654cellular_componentnucleoplasm
H0005737cellular_componentcytoplasm
H0005764cellular_componentlysosome
H0005765cellular_componentlysosomal membrane
H0005829cellular_componentcytosol
H0006974biological_processDNA damage response
H0007010biological_processcytoskeleton organization
H0010507biological_processnegative regulation of autophagy
H0016020cellular_componentmembrane
H0030307biological_processpositive regulation of cell growth
H0030838biological_processpositive regulation of actin filament polymerization
H0031669biological_processcellular response to nutrient levels
H0031929biological_processTOR signaling
H0031931cellular_componentTORC1 complex
H0031932cellular_componentTORC2 complex
H0032008biological_processpositive regulation of TOR signaling
H0032956biological_processregulation of actin cytoskeleton organization
H0038202biological_processTORC1 signaling
H0043066biological_processnegative regulation of apoptotic process
H0043539molecular_functionprotein serine/threonine kinase activator activity
H0045821biological_processpositive regulation of glycolytic process
H0046889biological_processpositive regulation of lipid biosynthetic process
H0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
H0071456biological_processcellular response to hypoxia
H0071470biological_processcellular response to osmotic stress
H1905857biological_processpositive regulation of pentose-phosphate shunt
I0003924molecular_functionGTPase activity
I0005515molecular_functionprotein binding
I0005525molecular_functionGTP binding
I0005634cellular_componentnucleus
I0005654cellular_componentnucleoplasm
I0005737cellular_componentcytoplasm
I0005764cellular_componentlysosome
I0005765cellular_componentlysosomal membrane
I0005829cellular_componentcytosol
I0006915biological_processapoptotic process
I0008104biological_processprotein localization
I0009267biological_processcellular response to starvation
I0010507biological_processnegative regulation of autophagy
I0016020cellular_componentmembrane
I0016787molecular_functionhydrolase activity
I0031625molecular_functionubiquitin protein ligase binding
I0031669biological_processcellular response to nutrient levels
I0032008biological_processpositive regulation of TOR signaling
I0033209biological_processtumor necrosis factor-mediated signaling pathway
I0034198biological_processcellular response to amino acid starvation
I0035556biological_processintracellular signal transduction
I0042593biological_processglucose homeostasis
I0042803molecular_functionprotein homodimerization activity
I0043495molecular_functionprotein-membrane adaptor activity
I0046982molecular_functionprotein heterodimerization activity
I0051219molecular_functionphosphoprotein binding
I0061462biological_processprotein localization to lysosome
I0071230biological_processcellular response to amino acid stimulus
I0072657biological_processprotein localization to membrane
I1904263biological_processpositive regulation of TORC1 signaling
I1990130cellular_componentGATOR1 complex
I1990131cellular_componentGtr1-Gtr2 GTPase complex
I1990877cellular_componentFNIP-folliculin RagC/D GAP
J0000287molecular_functionmagnesium ion binding
J0003924molecular_functionGTPase activity
J0005515molecular_functionprotein binding
J0005525molecular_functionGTP binding
J0005634cellular_componentnucleus
J0005654cellular_componentnucleoplasm
J0005737cellular_componentcytoplasm
J0005764cellular_componentlysosome
J0005765cellular_componentlysosomal membrane
J0005829cellular_componentcytosol
J0006351biological_processDNA-templated transcription
J0006915biological_processapoptotic process
J0007264biological_processsmall GTPase-mediated signal transduction
J0008104biological_processprotein localization
J0008380biological_processRNA splicing
J0009267biological_processcellular response to starvation
J0010507biological_processnegative regulation of autophagy
J0016020cellular_componentmembrane
J0016787molecular_functionhydrolase activity
J0019003molecular_functionGDP binding
J0031669biological_processcellular response to nutrient levels
J0032006biological_processregulation of TOR signaling
J0034198biological_processcellular response to amino acid starvation
J0043200biological_processresponse to amino acid
J0043231cellular_componentintracellular membrane-bounded organelle
J0043495molecular_functionprotein-membrane adaptor activity
J0046982molecular_functionprotein heterodimerization activity
J0051020molecular_functionGTPase binding
J0060090molecular_functionmolecular adaptor activity
J0061462biological_processprotein localization to lysosome
J0071230biological_processcellular response to amino acid stimulus
J0072657biological_processprotein localization to membrane
J0140767molecular_functionenzyme-substrate adaptor activity
J1903432biological_processregulation of TORC1 signaling
J1904263biological_processpositive regulation of TORC1 signaling
J1990131cellular_componentGtr1-Gtr2 GTPase complex
J1990877cellular_componentFNIP-folliculin RagC/D GAP
N0001558biological_processregulation of cell growth
N0001938biological_processpositive regulation of endothelial cell proliferation
N0005515molecular_functionprotein binding
N0005654cellular_componentnucleoplasm
N0005737cellular_componentcytoplasm
N0005764cellular_componentlysosome
N0005765cellular_componentlysosomal membrane
N0005829cellular_componentcytosol
N0006974biological_processDNA damage response
N0008361biological_processregulation of cell size
N0009267biological_processcellular response to starvation
N0009410biological_processresponse to xenobiotic stimulus
N0010494cellular_componentcytoplasmic stress granule
N0010506biological_processregulation of autophagy
N0010507biological_processnegative regulation of autophagy
N0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
N0016020cellular_componentmembrane
N0019901molecular_functionprotein kinase binding
N0030291molecular_functionprotein serine/threonine kinase inhibitor activity
N0030295molecular_functionprotein kinase activator activity
N0030307biological_processpositive regulation of cell growth
N0030425cellular_componentdendrite
N0030674molecular_functionprotein-macromolecule adaptor activity
N0031267molecular_functionsmall GTPase binding
N0031669biological_processcellular response to nutrient levels
N0031929biological_processTOR signaling
N0031931cellular_componentTORC1 complex
N0032008biological_processpositive regulation of TOR signaling
N0033138biological_processpositive regulation of peptidyl-serine phosphorylation
N0035176biological_processsocial behavior
N0038202biological_processTORC1 signaling
N0042325biological_processregulation of phosphorylation
N0043025cellular_componentneuronal cell body
N0044877molecular_functionprotein-containing complex binding
N0045672biological_processpositive regulation of osteoclast differentiation
N0045821biological_processpositive regulation of glycolytic process
N0045945biological_processpositive regulation of transcription by RNA polymerase III
N0046889biological_processpositive regulation of lipid biosynthetic process
N0071230biological_processcellular response to amino acid stimulus
N0071233biological_processcellular response to L-leucine
N0071333biological_processcellular response to glucose stimulus
N0071456biological_processcellular response to hypoxia
N0071470biological_processcellular response to osmotic stress
N0071889molecular_function14-3-3 protein binding
N0140767molecular_functionenzyme-substrate adaptor activity
N1900087biological_processpositive regulation of G1/S transition of mitotic cell cycle
N1901331biological_processpositive regulation of odontoblast differentiation
N1905857biological_processpositive regulation of pentose-phosphate shunt
Y0001558biological_processregulation of cell growth
Y0001938biological_processpositive regulation of endothelial cell proliferation
Y0005515molecular_functionprotein binding
Y0005654cellular_componentnucleoplasm
Y0005737cellular_componentcytoplasm
Y0005764cellular_componentlysosome
Y0005765cellular_componentlysosomal membrane
Y0005829cellular_componentcytosol
Y0006974biological_processDNA damage response
Y0008361biological_processregulation of cell size
Y0009267biological_processcellular response to starvation
Y0009410biological_processresponse to xenobiotic stimulus
Y0010494cellular_componentcytoplasmic stress granule
Y0010506biological_processregulation of autophagy
Y0010507biological_processnegative regulation of autophagy
Y0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
Y0016020cellular_componentmembrane
Y0019901molecular_functionprotein kinase binding
Y0030291molecular_functionprotein serine/threonine kinase inhibitor activity
Y0030295molecular_functionprotein kinase activator activity
Y0030307biological_processpositive regulation of cell growth
Y0030425cellular_componentdendrite
Y0030674molecular_functionprotein-macromolecule adaptor activity
Y0031267molecular_functionsmall GTPase binding
Y0031669biological_processcellular response to nutrient levels
Y0031929biological_processTOR signaling
Y0031931cellular_componentTORC1 complex
Y0032008biological_processpositive regulation of TOR signaling
Y0033138biological_processpositive regulation of peptidyl-serine phosphorylation
Y0035176biological_processsocial behavior
Y0038202biological_processTORC1 signaling
Y0042325biological_processregulation of phosphorylation
Y0043025cellular_componentneuronal cell body
Y0044877molecular_functionprotein-containing complex binding
Y0045672biological_processpositive regulation of osteoclast differentiation
Y0045821biological_processpositive regulation of glycolytic process
Y0045945biological_processpositive regulation of transcription by RNA polymerase III
Y0046889biological_processpositive regulation of lipid biosynthetic process
Y0071230biological_processcellular response to amino acid stimulus
Y0071233biological_processcellular response to L-leucine
Y0071333biological_processcellular response to glucose stimulus
Y0071456biological_processcellular response to hypoxia
Y0071470biological_processcellular response to osmotic stress
Y0071889molecular_function14-3-3 protein binding
Y0140767molecular_functionenzyme-substrate adaptor activity
Y1900087biological_processpositive regulation of G1/S transition of mitotic cell cycle
Y1901331biological_processpositive regulation of odontoblast differentiation
Y1905857biological_processpositive regulation of pentose-phosphate shunt
Functional Information from PDB Data
site_idAC1
Number of Residues16
Detailsbinding site for residue GTP C 401
ChainResidue
CGLY17
CGLY40
CALA41
CTHR42
CGLY64
CGLY65
CSER163
CILE164
CSER18
CGLY19
CLYS20
CTHR21
CSER22
CTHR36
CARG37
CLEU39

site_idAC2
Number of Residues7
Detailsbinding site for residue GDP D 401
ChainResidue
DARG71
DSER72
DGLY73
DLYS74
DSER75
DSER76
DILE220

site_idAC3
Number of Residues16
Detailsbinding site for residue GTP I 401
ChainResidue
IGLY17
ISER18
IGLY19
ILYS20
ITHR21
ISER22
ITHR36
IARG37
ILEU39
IGLY40
IALA41
ITHR42
IGLY64
IGLY65
ISER163
IILE164

site_idAC4
Number of Residues7
Detailsbinding site for residue GDP J 401
ChainResidue
JARG71
JSER72
JGLY73
JLYS74
JSER75
JSER76
JILE220

Functional Information from PROSITE/UniProt
site_idPS00214
Number of Residues18
DetailsFABP Cytosolic fatty-acid binding proteins signature. KAYkVnpDmNFEvFIHKV
ChainResidueDetails
DLYS163-VAL180

site_idPS00915
Number of Residues15
DetailsPI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. LKgh.EDLRQDervmQ
ChainResidueDetails
ALEU2186-GLN2200

site_idPS00916
Number of Residues21
DetailsPI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. SlAvmsMvgYILgLgDRHpsN
ChainResidueDetails
ASER2323-ASN2343

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. MYTGgeDcTARIWDL
ChainResidueDetails
EMET100-LEU114

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:31530866
ChainResidueDetails
YSER982
NSER44
NSER122
NSER836
NSER982
ATHR2245
AMET2345
AILE2356
BSER2165
BGLN2167
BLEU2185
BGLU2190
BTYR2225
BGLY2238
BTRP2239
BVAL2240
BTHR2245
BMET2345
BILE2356
YSER836
YSER44
YSER122

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphoserine; by MAPK8 => ECO:0000269|PubMed:19864431, ECO:0000269|PubMed:22493283, ECO:0000269|PubMed:31530866, ECO:0007744|PubMed:23186163
ChainResidueDetails
AASP2357
BLYS2187
BASN2343
BASP2357
YSER696
NSER696

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphothreonine; by MAPK8 => ECO:0000269|PubMed:19864431, ECO:0000269|PubMed:22493283, ECO:0000269|PubMed:31530866
ChainResidueDetails
CTHR36
CILE164
IGLY19
ITHR21
ITHR36
IILE164
YTHR706
NTHR706

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine; by RPS6KA1 => ECO:0000269|PubMed:18722121, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163
ChainResidueDetails
ILYS20
ITHR42
YSER719
NSER719

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine; by RPS6KA1 => ECO:0000269|PubMed:18722121
ChainResidueDetails
ISER22
IGLY65
YSER721
NSER721

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphoserine; by AMPK and RPS6KA1 => ECO:0000269|PubMed:18439900, ECO:0000269|PubMed:18722121, ECO:0000269|PubMed:37541260, ECO:0007744|PubMed:23186163
ChainResidueDetails
NSER722
YSER722

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
DASP181
JASN90
JTHR96
JASP181
NSER738
YSER738

site_idSWS_FT_FI8
Number of Residues2
DetailsMOD_RES: Phosphoserine; by PKA => ECO:0000269|PubMed:31112131
ChainResidueDetails
YSER791
NSER791

site_idSWS_FT_FI9
Number of Residues2
DetailsMOD_RES: Phosphoserine; by AMPK => ECO:0000269|PubMed:18439900, ECO:0000269|PubMed:37541260
ChainResidueDetails
CLYS244
ILYS142
ILYS220
ILYS230
ILYS244
CLYS220
CLYS230
YSER792
NSER792

site_idSWS_FT_FI10
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:19864431
ChainResidueDetails
YSER855
NSER855
JLYS179
JILE220

site_idSWS_FT_FI11
Number of Residues2
DetailsMOD_RES: Phosphoserine; by MTOR => ECO:0000269|PubMed:19864431, ECO:0000269|PubMed:31530866, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
YSER859
NSER859

site_idSWS_FT_FI12
Number of Residues2
DetailsMOD_RES: Phosphoserine; by MAPK8, MTOR and NLK => ECO:0000269|PubMed:19864431, ECO:0000269|PubMed:22493283, ECO:0000269|PubMed:26588989, ECO:0000269|PubMed:31530866, ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
YSER863
NSER863

site_idSWS_FT_FI13
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163
ChainResidueDetails
YTHR865
NTHR865

site_idSWS_FT_FI14
Number of Residues2
DetailsMOD_RES: Phosphoserine; by TBK1 => ECO:0000269|PubMed:19864431, ECO:0000269|PubMed:26588989, ECO:0000269|PubMed:31530866, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
YSER877
NSER877

site_idSWS_FT_FI15
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0000269|PubMed:30197302, ECO:0000269|PubMed:32561715
ChainResidueDetails
YLYS1097
NLYS1097

site_idSWS_FT_FI16
Number of Residues2
DetailsCARBOHYD: O-linked (GlcNAc) threonine => ECO:0000269|PubMed:37541260
ChainResidueDetails
YTHR700
NTHR700

site_idSWS_FT_FI17
Number of Residues6
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:35927303
ChainResidueDetails
YLYS932
YLYS948
NLYS932
NLYS948

219869

PDB entries from 2024-05-15

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