6RPU

Structure of the ternary complex of the IMPDH enzyme from Ashbya gossypii bound to the dinucleoside polyphosphate Ap5G and GDP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003824	molecular_function	catalytic activity
A	0003938	molecular_function	IMP dehydrogenase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0006164	biological_process	purine nucleotide biosynthetic process
A	0006177	biological_process	GMP biosynthetic process
A	0006183	biological_process	GTP biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	25
Details	binding site for residue G5P A 601

Chain	Residue
A	LYS115
A	ARG167
A	ARG167
A	ASP168
A	THR184
A	ASP186
A	VAL187
A	ILE188
A	GLY209
A	LYS210
A	PRO212
A	TYR116
A	MET223
A	SER225
A	THR227
A	ASP228
A	LYS231
A	HOH703
A	PRO124
A	VAL125
A	PHE145
A	ALA146
A	GLY147
A	THR165
A	SER166

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site_id	AC2
Number of Residues	9
Details	binding site for residue GDP A 602

Chain	Residue
A	GLU117
A	ASN118
A	GLY119
A	ASN200
A	ASP228
A	LEU229
A	ASN232
A	LYS240
A	LYS245

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site_id	AC3
Number of Residues	4
Details	binding site for residue ACT A 603

Chain	Residue
A	GLY368
A	GLY369
A	GLY390
A	GLY391

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site_id	AC4
Number of Residues	2
Details	binding site for residue ACT A 604

Chain	Residue
A	SER278
A	SER279

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site_id	AC5
Number of Residues	1
Details	binding site for residue ACT A 605

Chain	Residue
A	SER234

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site_id	AC6
Number of Residues	1
Details	binding site for residue ACT A 606

Chain	Residue
A	SER494

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Functional Information from PROSITE/UniProt

site_id	PS00487
Number of Residues	13
Details	IMP_DH_GMP_RED IMP dehydrogenase / GMP reductase signature. LRIGMGsGSICiT

Chain	Residue	Details
A	LEU324-THR336

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